A5020924902- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Manufacturing Process and Optimization
- Engineering Applied Research
- Advanced Multi-Objective Optimization Algorithms
- Risk and Safety Analysis
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Neurological disorders and treatments
- Prion Diseases and Protein Misfolding
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Structural Integrity and Reliability Analysis
- Product Development and Customization
- Functional Brain Connectivity Studies
- Probabilistic and Robust Engineering Design
- Design Education and Practice
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Glioma Diagnosis and Treatment
Soonchunhyang University
2008-2025
Soonchunhyang University Hospital
2024
Hyoja Geriatric Hospital
2010-2022
Seoul Veterans Hospital
2012-2021
National Neuroscience Institute
2020
Duke-NUS Medical School
2020
Seoul Medical Center
2012-2018
Seoul National University
2005-2016
Seoul National University Bundang Hospital
2007-2013
Catholic Kwandong University
2013
Transient global amnesia (TGA) is a rare amnestic syndrome characterized by the sudden onset of selective anterograde and retrograde with time course up to 24 hours. Recent studies have found high frequency small high-signal abnormalities in hippocampus on diffusion-weighted imaging (DWI), accordingly ischemia has been proposed as an etiology TGA. We hypothesized that TGA lesions occur preferentially CA1 region hippocampus, which known be susceptible ischemia.Twenty consecutive patients...
Aim The aim of the present study was to evaluate efficacy a multidomain program in patients with A lzheimer's disease ( AD ). Methods total 53 probable participated study. participants were classified cognitive programming group n = 32) and control 21). Participants intervention received stimulation including art, music, recollection horticultural therapy, each period lasting 1 h. This repeated five times per week over 6 months at S eongdong‐gu C enter for D ementia. M ini‐ ental tate E...
Dementia subtypes, including Alzheimer's dementia (AD), with Lewy bodies (DLB), and frontotemporal (FTD), pose diagnostic challenges. This review examines the effectiveness of
Background: Creutzfeldt-Jakob disease (CJD) is a rare and rapidly progressive, invariably fatal neurodegenerative disorder believed to be caused by an abnormal isoform of cellular glycoprotein known as the prion protein. The develops in very different ways, such sporadic, genetic, iatrogenic. We aim identify incidence CJD genotypes registered statutory infectious surveillance system from 2017 2023 analyze types characteristics domestic pathogenic serve basis for preventing...
Dementia often accompanies behavioral and psychological symptoms of dementia (BPSD), including agitation, aggression, depression, psychosis, which impact patients' quality life caregiver burden. Effective management BPSD is essential to support patient well-being. This study presents evidence-based clinical practice guidelines for pharmacological treatments in dementia, focusing on antipsychotics, antidepressants, cognitive enhancers, other medications. guideline was developed by the Korean...
This clinical practice guideline provides evidence-based recommendations for treatment of dementia, focusing on cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists Alzheimer's disease (AD) other types dementia. Using the Population, Intervention, Comparison, Outcomes (PICO) framework, we developed key questions conducted systematic literature reviews. A multidisciplinary panel experts, organized by Korean Dementia Association, evaluated randomized controlled trials...
Background: Hospitalization for severe neuropsychiatric symptoms in Alzheimer’s disease (AD) presents challenges, often requiring environments that ensure safety while addressing therapeutic needs. Traditional closed wards, originally designed psychiatric conditions like schizophrenia, may not fully address the unique needs of AD patients. This study evaluates effectiveness a Specialized Dementia Ward (SDW) tailored patients compared to General (GW). Methods: A retrospective 51 an SDW...
Background Ginkgo biloba is widely used in some regions as an adjunct therapy for Alzheimer’s disease (AD). Its potential mechanisms include antioxidative and anti-amyloid properties, yet clinical evidence remains mixed. Objective We investigated whether combining with donepezil confers additional benefits amyloid PET-positive AD patients. also explored changes the plasma biomarker MDS-Oaβ (Multimer Detection System–Oligomeric Aβ), which reflects propensity of Aβ monomers to form oligomers....
Background and Purpose: Cognitive gait disturbance are common symptoms in Parkinson's disease (PD).Although the relationship between cognitive impairment dysfunction PD has been suggested, specific patterns according to cognition not fully demonstrated yet.Therefore, aim of this study was investigate patients with or without impairment.Methods: We studied 86 at an average 4.8 years after diagnosis PD.Cognitive defined as scoring 1.5 standard deviation below age-and education-specific means...
Cognitive training is known to be an effective tool in enhancing cognitive functioning. Research has also shown that playing video game improves certain aspects of visual attention and processing speed. The effect computer-based not been demonstrated so far. This study therefore evaluated whether improved the abilities patients with early stage Alzheimer's dementia.Totally, 20 participants (early dementia) participated this study. To test effectiveness programs cognition, all were randomly...
Aim: Sensitive, specific neuropsychological screening tests, such as the Addenbrooke's Cognitive Examination Revised (ACE‐R), are essential for dementia diagnosis. We aimed to validate use of Korean version ACE‐R (K‐ACER) differentiate Alzheimer's disease (AD) from subcortical ischemic vascular (SIVD). Methods: Standard tests were applied 156 subjects (84 controls, 30 AD, 42 SIVD), and total sub‐domain scores on K‐ACER, well ratio (VLOM), compared. Results: The reliability K‐ACER was very...
The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and time. There is limited evidence that these findings are similar those observed in large-scale consecutive patients TGA clinical practice.Patients clinically diagnosed underwent magnetic resonance studies, consecutively, three sets (standard protocols, the protocol I II) which resolution, slice thickness, time interval between...
In this study, there was an investigation as to whether is a functional difference in essential tremor (ET), according responses beta-blockers, by evaluating regional changes cerebral glucose metabolism.Seventeen male patients with ET were recruited and categorized into two groups: 8 that responded medical therapy (group A); 9 did not respond B). Eleven age-sex matched healthy control subjects also included study. All underwent F-18 fluorodeoxyglucose (FDG)-PET, evaluated for their severity...
Cognitive training refers to a series of standardized tasks with inherent challenges that target specific cognitive domains. Positive outcome in persons Alzheimer's disease has been reported. In this study, the objective was design sets program, "Gipum-seo" which is combined training, consists different levels difficulty using predesigned paper-and-pencil exercises. Also, evaluate effects on patients' early stage disease.The subjects for study were forty participants who diagnosed dementia....
Introduction Alzheimer’s disease (AD), the most common form of dementia, is characterized by progressive cognitive decline. To address this, we conducted a randomized, double-blinded, sham-controlled study to investigate therapeutic potential transcranial direct current stimulation (tDCS) on patients with amyloid positron emission tomography (PET)- positive AD. Methods Participants already undergoing pharmacological treatment and testing for PET were divided into Active-tDCS ( n = 8)...
Availabilities of subsea Blowout Preventers (BOP) in the Gulf Mexico Outer Continental Shelf (GoM OCS) is investigated using a Markov method. An updated β factor model by SINTEF used for common-cause failures multiple redundant systems. Coefficient values failure rates are derived PDS (reliability computer-based safety systems, Norwegian acronym) The blind shear ram preventer system BOP components considers demand rate to reflect reality more. models considering one or two introduced. Two...
Two parallel pathways have been proposed between the hippocampus and neocortex. Recently, anterior posterior showed distinct connectivity with different cortical areas in an fMRI study. We investigated whether two could be confirmed patients transient global amnesia (TGA) which is a natural lesion model of perturbation hippocampus. In addition, we evaluated relationship location hippocampal various clinical variables.A consecutive series 37 were identified from TGA registry database Seoul...