A5103094160- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Bone and Joint Diseases
- Neurological and metabolic disorders
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Optical Imaging and Spectroscopy Techniques
- Neural and Behavioral Psychology Studies
- Orthopedic Infections and Treatments
- Treatment of Major Depression
- Stroke Rehabilitation and Recovery
Catholic University of Korea
2015-2025
Incheon St. Mary's Hospital
2016-2025
In-Q-Tel
2016
Sungae Hospital
2016
Chung-Ang University
2012
Seoul St. Mary's Hospital
2012
University of Seoul
2005
Purpose: Increasing attention has been paid to low-intensity transcranial focused ultrasound (tFUS) for its potential therapeutic effects in Alzheimer's disease (AD). While preclinical studies have shown promising of tFUS AD models, efficacy and safety remain unclear humans. In this pilot study, we investigated the on blood-brain barrier opening, regional cerebral metabolic rate glucose (rCMRglu), cognition patients with AD.Methods: After receiving institutional review board approval, four...
Abstract Background Mild cognitive impairment (MCI) is a syndrome that disrupts an individual’s function but preserves activities of daily living. MCI thought to be prodromal stage dementia, which patients’ lives and causes severe dysfunction. Although extensive clinical trials have attempted slow or stop the dementia conversion, results been largely unsuccessful. The purpose this study was determine whether noninvasive electrical stimulation changes glucose metabolism. Methods Sixteen...
The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction.However, the poor viability MSCs after transplantation critically limits efficacy this strategy.The expression microRNA-210 (miR-210) is induced by hypoxia and important cell survival under hypoxic conditions.Hypoxia increases levels inducible factor-1 (HIF-1) protein miR-210 in human (hMSCs).miR-210 positively regulates HIF-1α activity.Furthermore, also through regulation .To...
We describe the case of a 67-year-old man with lung cancer, who developed pulmonary tuberculosis (TB) following chemotherapy and subsequently exhibited paradoxical reaction on positron emission tomography/computed tomography (PET/CT) after initiating antituberculosis therapy. While consolidations improved treatment, newly detected hypermetabolic mediastinal lymph nodes appeared PET/CT. Based clinical course, we provisionally concluded that lymphadenopathy represented reaction. Endobronchial...
Objective Electroacupuncture (EA) is a traditional medicine in patients with post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) potent growth involved recovery following cerebral injury. The aim of the present study was to investigate whether EA increases BDNF levels and facilitates functional recovery. Methods Occlusion middle artery performed rats (N=12) followed by reperfusion. applied at GV20 (Baihui) acupoint. Motor sensory functions were monitored on Garcia scale for...
Woochul Chang, Ran Kim, Sang In Park, Yu Jin Jung, Onju Ham, Jihyun Lee, Ji Hyeong Sekyung Oh, Min Young Jongmin Moon-Seo Yong-An Chung, Ki-Chul Hwang, and Lee-So Maeng. Mol. Cells 2015;38:643-50. https://doi.org/10.14348/molcells.2015.0050
<i>Objectives:</i> Experimental data and case reports of patients with intractable epilepsy treated deep brain stimulation (DBS) the subthalamic nucleus (STN) suggest a considerable anticonvulsant effect. However, no satisfactory mechanisms action have yet been elucidated. We investigated putative therapeutic DBS from cerebral perfusion changes as measured by subtracting SPECT image pre-DBS period that chronic post-DBS state. <i>Methods:</i> Two who had previous...
Objectives The purpose of this study was to evaluate the clinical value preoperative [18F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) by comparing it neck sonography in papillary thyroid carcinoma. Methods diagnostic accuracies PET/CT and for detecting cervical node metastasis were compared. association between FDG uptake primary tumor prognostic factors differentiated cancer, such as size, multiplicity, extrathyroid extension, lymph metastasis,...
In this study, there was an investigation as to whether is a functional difference in essential tremor (ET), according responses beta-blockers, by evaluating regional changes cerebral glucose metabolism.Seventeen male patients with ET were recruited and categorized into two groups: 8 that responded medical therapy (group A); 9 did not respond B). Eleven age-sex matched healthy control subjects also included study. All underwent F-18 fluorodeoxyglucose (FDG)-PET, evaluated for their severity...
Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro chemically, induced HCC model. OD significantly enhanced apoptosis antiproliferative activity reduced migration ability cells. In vivo , treated twice day 28 days after confirmed model through 2-[ 18...
The aims of this study were to investigate the effects daily low-dose tadalafil on cognitive function and examine whether there was a change in cerebral blood flow (CBF) patients with erectile dysfunction (ED) mild impairment.Male aged 50 75 years at least three months ED (International Index Erectile Function [IIEF]-5 score ≤ 21) impairment (Montreal Cognitive Assessment [MoCA] 22) included study. subjects prescribed PDE5 inhibitor (tadalafil 5 mg) be taken once for eight weeks. Changes...
Persistent postural-perceptual dizziness (PPPD) is a functional vestibular disorder that causes chronic interfering with daily activities. Transcranial direct current stimulation (tDCS) has reportedly improved in patients phobic postural vertigo an open-label trial. However, no randomized, double-blind, sham-controlled study been conducted on its therapeutic efficacy PPPD.This was to investigate the and safety of tDCS as add-on treatment pharmacotherapy PPPD. In addition, neuroimaging used...
Objective Previous neuroimaging studies on romantic love have focused determining how the visual stimuli that serve as a representation of loved ones induce neural activation patterns love. The purpose this study was to investigate temporal changes in over period 6 months and their correlated neurophysiological changes. Methods Five heterosexual couples (n=10, mean age 21.1±1.97) who started dating not less than 100 days previously were recruited measure blood oxygen level dependent (BOLD)...
Aim: Inconsistent results continue to be reported in studies that examine the neural correlates of cognitive behavioral therapy (CBT) patients with panic disorder. We examined changes regional cerebral blood flow (rCBF) associated alleviation anxiety by CBT patients. Methods: The change rCBF and clinical symptoms before after were assessed using single photon emission computed tomography various measures analyzed. Results: Fourteen subjects who completed showed significant improvements on...
Subjective memory impairment (SMI) may precede mild cognitive (MCI) stage and would offer an earlier therapeutic opportunity than MCI would. However, it is not clear whether complaints of forgetfulness are truly reflective objective dysfunction or impairments in other domains. The aim this current longitudinal study was to investigate changes various functions regional cerebral metabolic rate glucose (rCMRglc) among elderly women with SMI.Clinical evaluation, comprehensive neuropsychological...
Gliomas are the most common type of malignant primary brain tumors. Some treatments gliomas exist, but they rarely curative. Mesenchymal stem cells (MSCs) emerging as potential modes targeted cancer therapy owing to their capacity for homing toward tumor sites. It has been proposed that MSCs derived from various sources, such bone marrow, adipose tissue and umbilical cord blood, can be used cell-based Here, obtained synovial fluid osteoarthritis or rheumatoid arthritis patients were...
The purpose of this study was to investigate the predictable value pretreatment (18)F-fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) in radiotherapy (RT) for patients with hepatocellular carcinoma (HCC) or portal vein tumor thrombosis (PVTT).We conducted a retrospective analysis 36 stage I-IV HCC treated RT. (18)F-FDG PET-CT performed before Treatment target determined PVTT lesions by treatment aim. They were irradiated at median prescription dose 50...
Some groups have focused on the detection and management of subjective memory impairment (SMI) as stage that precedes mild cognitive (MCI). However, there been few clinical studies examined biomarkers SMI to date.To investigate differences in glucose metabolism a prodromal marker dementia patients with SMI, MCI, healthy controls using brain F-18 fluoro-2-deoxyglucose positron emission tomography (FDG-PET).Sixty-eight consecutive 47 42 age-matched subjects were recruited. All underwent...