A5002790890- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Health and Wellbeing Research
- Cholinesterase and Neurodegenerative Diseases
- Pharmacy and Medical Practices
- Frailty in Older Adults
- EEG and Brain-Computer Interfaces
- Neurological Disorders and Treatments
- Medical Imaging Techniques and Applications
- Diverse Approaches in Healthcare and Education Studies
- Cerebrospinal fluid and hydrocephalus
- Stroke Rehabilitation and Recovery
- Medical Image Segmentation Techniques
- Brain Tumor Detection and Classification
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Microwave Imaging and Scattering Analysis
- Ginkgo biloba and Cashew Applications
- Neurobiology of Language and Bilingualism
- Acute Ischemic Stroke Management
- Advanced Image and Video Retrieval Techniques
Shaanxi University of Chinese Medicine
2025
Seoul St. Mary's Hospital
2015-2024
Catholic University of Korea
2015-2024
Shenyang Pharmaceutical University
2024
Yeouido St. Mary's Hospital
2021
China Academy of Space Technology
2021
Yibin University
2021
Dalian University of Technology
2021
Institute of Electronics
2021
Simon Fraser University
2016
<b><i>Background/Aims:</i></b> We investigated the histopathological correlates of white matter hyperintensities (WMHs) in participants with Alzheimer's disease (AD) or cerebrovascular disease, and aged controls. <b><i>Methods:</i></b> reviewed 57 who had neuropathology whom neuroimaging was done. In addition to AD pathology, cortical microinfarcts, lacunes, cerebral hemorrhages were assessed. Small-vessel included arteriolosclerosis amyloid...
Subjective memory impairment (SMI) is common among older adults. Increasing evidence suggests that SMI a risk factor for future cognitive decline, as well mild and dementia. Medial temporal lobe structures, including the hippocampus entorhinal cortex, are affected in early stages of Alzheimer's disease. The current study examined gray matter (GM) volume microstructural changes hippocampal regions individuals with SMI, compared elderly control participants without complaints.A total 45 (mean...
Abstract Background Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the application in clinical settings, we developed evaluated accuracy a machine learning algorithm using multi-center NPT data. Methods Multi-center data were obtained from 14,926 formal neuropsychological assessments (Seoul Screening Battery), which classified into normal...
Mild cognitive impairment (MCI) has been defined as a transitional state between normal aging and Alzheimer disease. Diffusion tensor imaging (DTI) can estimate the microstructural integrity of white matter tracts in MCI. We evaluated changes MCI patients with DTI. recruited 11 who met working criteria elderly controls. The mean diffusivity (MD) fractional anisotropy (FA) were measured 26 regions brain interest (ROIs) method. In patients, FA values significantly decreased hippocampus,...
<i>Background/Aims: </i>The possible influence of apolipoprotein E <i>(ApoE)</i> genotype on the response to acetylcholinesterase inhibitor therapy in patients with Alzheimer’s disease (AD) remains a matter controversy. In order address this issue, we investigated effects <i>ApoE</i> clinical donepezil mild moderate AD. <i>Methods: </i>An open study was carried out 51 probable AD who were treated 5–10 mg per day for 48 weeks.<i> Results:...
Background and Purpose White matter hyperintensities (WMH) are frequently observed on MRI in ischemic stroke patients as well normal elderly individuals. Besides the progression of WMH, regression WMH has been rarely reported. Thus, we aimed to investigate how change over time with stroke, particularly focusing regression. Methods We enrolled who underwent brain more than twice at least a 6 month time-interval. Based T2-weighted or FLAIR MRI, were visually assessed, followed by semiautomatic...
Objective: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) can be an alternative treatment option for intractable epilepsy patients. Since CM may involved in widespread cortico-subcortical networks, identification cortical sub-networks specific to target stimuli provide further understanding on underlying mechanisms DBS. Several structures have distinguishing connections that related pivotal propagation and subsequent clinical effect Methods: To explore core their...
Abstract Developing reliable biomarkers is important for screening Alzheimer’s disease (AD) and monitoring its progression. Although EEG non-invasive direct measurement of brain neural activity has potentials various neurologic disorders, vulnerability to noise, difficulty in clinical interpretation quantification signal information have limited application. There been many research about machine learning (ML) adoption with EEG, but the accuracy detecting AD not so high or validated Aβ PET...
Introduction: Subjective cognitive decline (SCD) is considered a preclinical manifestation of Alzheimer’s disease (AD). Recent research suggests that subtle changes in SCD are linked to an increased risk clinical decline. This study investigates the longitudinal trajectories both objective and self-reported functions individuals with SCD, focus on impact impairment (SCI). Methods: A total 107 at least two annual follow-ups, were included this study. We analyzed subjective functions, assessed...
This study compares sleep duration and stroke risk between residents of China the U.S. during outside COVID-19 pandemic, examining age as an interaction effect. analyzed data from National Health Nutrition Examination Survey (NHANES) Retirement Longitudinal Study (CHARLS). A total 9131 American adults participated 2017 to March 2020, 7678 August 2021 2023. In China, 13,514 in 2018 9441 2020. Stroke incidence was assessed via survey responses, with "yes" indicating a history stroke....
The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. objective of this study compare the linguistic cultural variations MMSE used in various Asian countries. With this, we can analyze strengths weaknesses consider using a common version future international clinical studies Asia. We collected MMSEs 11 nations. After translating those into English, compared them understand...
Cardiac tagging magnetic resonance imaging (t-MRI) is the gold standard for regional myocardium deformation and cardiac strain estimation. However, this technique has not been widely used in clinical diagnosis, as a result of difficulty motion tracking encountered with t-MRI images. In paper, we propose novel deep learning-based fully unsupervised method vivo on We first estimate field (INF) between any two consecutive frames by bi-directional generative diffeomorphic registration neural...
Background & Objective: Early-onset Alzheimer's disease (EOAD, onset age < 65 years) may differ from late-onset (LOAD) in terms of cognitive profiles and neuropsychiatric symptoms. There have been few studies for Korean EOA
Background and PurposezzAlzheimer's disease (AD) is associated with structural alterations in the medial temporal lobe (MTL) functional posterior cortical region, especially early stages.However, it unclear what mechanisms underlie these regional discrepancies or whether hypometabolism reflects disconnection from MTL lesion result of local pathology.The precuneus, an area posteromedial cortex that involved stages AD, has recently received a great deal attention neuroimaging studies.To assess...
Summary Purpose: In comparison to temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (TLE‐HS), TLE without HS (TLE‐NH) have a similar clinical course but may result in worse surgical outcome. We investigated whether the features related lack of can be explained by water diffusion abnormalities throughout tensor imaging (DTI) voxel‐based analysis. Methods: Nineteen TLE‐HS (left/right 12:7), 18 TLE‐NH 10:8), and 20 controls were included study. By statistical parametric mapping...
Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia.This study investigated gray and white matter changes in the brains SMI patients compared with normal controls mild cognitive (MCI) patients.We recruited 28 controls, subjects SMI, 29 MCI aged 60 or older.We analyzed using voxel-based morphometry (VBM), hippocampal volumetry regions interest diffusion tensor imaging (DTI).DTI parameters corpus callosum cingulum showed more those they...
Background: Effective treatments to alleviate depression in Alzheimer's disease (AD) have been scarce. Objective: To investigate the efficacy and tolerability of escitalopram treatment AD. Methods: In this 12-week randomized, double-blind, placebo-controlled trial with open- label, extension, AD subjects over 50 years age, defined by Olin's provisional diagnostic criteria, were enrolled. The Cornell Scale for Depression Dementia (CSDD), other measures cognition repeated. Results: 91...
Objectives The present study examined self‐reports and informant reports of cognitive function discrepancies between the two reporting methods in healthy controls (HC), subjective decline (SCD), mild impairment (MCI), very Alzheimer disease (AD) using three questionnaires. Methods included a total 300 individuals (mean age: 74.4 ± 5.7 y), including 130 HC, 70 SCD, 51 MCI, 49 AD patients. Self‐ratings ratings were assessed Korean Dementia Screening Questionnaire‐Cognition (KDSQ‐C), AD8,...