This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain physical functions in high-risk older adults. In randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through clinical interview conducted by dementia specialist. Cognitive assessments were performed neuropsychologists according standardized methods, including Mini-Mental State...

Although pelvic irradiation is effective for the treatment of various cancer types, many patients who receive radiotherapy experience serious complications. Gut microbial dysbiosis was hypothesized to be related occurrence radiation-induced complications in patients. Given lack clinical or experimental data on impact radiation gut microbiota, a prospective observational study microbiota performed gynecological receiving radiotherapy. In current study, overall composition and alteration were...

We evaluated the patterns of quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD), Lewy body (LBD), and mixed disease. Sixteen AD, 38 LBD, 20 disease, 17 control participants were recruited underwent EEG. The theta/alpha ratio theta/beta measured. relationship log-transformed (TAR) (TBR) group, presence AD clinical symptoms evaluated. Participants LBD groups had higher TBR all lobes except for occipital lobe than those group. was independently associated...

This study is aimed to determine significant physiological parameters of brain and heart under meditative state, both in each activities their dynamic correlations. Electrophysiological changes response meditation were explored 12 healthy volunteers who completed 8 weeks a basic training course autogenic meditation. Heart coherence, representing the degree ordering oscillation rhythm intervals, increased significantly during Relative EEG alpha power lagged coherence also increased. A slowing...

Background: It has long been theorized that a relatively robust dietary intake impacts cognitive function.The aim of the study was to explore and function in healthy Korean children adolescents.Methods: Three hundred seventeen with no previous diagnosis neurologic or psychiatric disorders were evaluated (167 girls 150 boys mean age 11.8 ± 3.3 years).Analysis indicators including food frequency questionnaires (FFQs) consisting 76 items neurocognitive tests symbol digit modalities (SDMT),...

Abstract Developing reliable biomarkers is important for screening Alzheimer’s disease (AD) and monitoring its progression. Although EEG non-invasive direct measurement of brain neural activity has potentials various neurologic disorders, vulnerability to noise, difficulty in clinical interpretation quantification signal information have limited application. There been many research about machine learning (ML) adoption with EEG, but the accuracy detecting AD not so high or validated Aβ PET...

Background: The purpose of this study was to measure the sleep quality and duration in healthy adults identify any influencing factors.Methods: This a descriptive research investigation that evaluated 240 at least 19 years age.The data were assessed using following self-administered questionnaires: Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory, State-Trait Anxiety Inventory-Korean YZ, Fatigue Severity Scale. Results:The PSQI global score 5.69 ± 3.23, 59.6% participants...

Antioxidant supplementations are commonly used as an ergogenic aid for physical exercise despite its limited evidence. The study aimed to investigate the effects of a polyphenol mixture and vitamins on endurance capacity. Seventy regularly exercising male participants were randomly assigned receive oligomerized lychee fruit extract, vitamin C (800 mg) E (320 IU), or placebo 30 consecutive days. results showed that extract significantly elevated submaximal running time (p = 0.01). adjusted...

The underlying changes in heart coherence that are associated with reported EEG response to meditation have been explored. We measured and rate variability (HRV) before during autogenic meditation. Fourteen subjects participated the study. Heart scores were significantly increased compared baseline. found near significant decrease high beta absolute power, increase alpha relative power increases lower(alpha) higher(above beta) band 3 minute epochs of coherent noncoherence at could reflect...

Our previous study demonstrated that phlorotannin supplement had a sleep‐promoting effect in rodents. In the present study, we investigated whether could improve sleep subjects with self‐reported disturbances. randomized, double‐blind, placebo‐controlled trial, 24 consumed either placebo or (500 mg/day) for 1 week, 30–60 min prior to bedtime. Sleep parameters were assessed at baseline and week questionnaires polysomnography. At end of treatment period, complete sets from 20 subjects....

We describe the utility of a standardized index (Z-score) in quantitative EEG (QEEG) capable when referenced to resting-state, sex- and age-differentiated QEEG normative database (ISB-NormDB). Our ISB-NormDB comprises data for 1,289 subjects (553 males, 736 females) ages 4.5 81 years that met strict criteria. A de-noising process allowed stratification based on variability between normal healthy men women at various age ranges. The set is stratified by sex provides unique, highly accurate...

Abstract Background The memory impairments in mild cognitive impairment (MCI) can be classified into encoding (EF) and retrieval (RF) failure, which affected by underlying pathomechanism. We explored the differences structurally functionally. Methods compared quantitative electroencephalography (qEEG) power spectra connectivity between 87 MCI patients with EF 78 RF using iSyncBrain® (iMediSync Inc., Republic of Korea) ( https://isyncbrain.com/ ). Voxel-based morphometric analysis gray matter...

Abstract We investigated the efficacy of donepezil for mild cognitive impairment in Parkinson’s disease (PD-MCI). This was a prospective, non-randomized, open-label, two-arm study. Eighty PD-MCI patients were assigned to either treatment or control group. The group received 48 weeks. primary outcome measures Korean version Mini-Mental State Exam and Montreal Cognitive Assessment scores. Secondary Clinical Dementia Rating, Unified Disease Rating Scale part III, Global Impression Progression...

Objective Fatigue is a common, debilitating nonmotor symptom of Parkinson’s disease (PD), but its mechanism poorly understood. We aimed to determine whether electroencephalography (EEG) could objectively measure fatigue and explore the pathophysiology in PD.Methods studied 32 de novo PD patients who underwent EEG. compared brain activity between 19 without 13 with via EEG power spectra graphs, including global efficiency, characteristic path length, clustering coefficient, small-worldness,...

The sex ratio (F:M) in the same population of oyster, Crassostrea gigas at commencement study (2007) was 1:1.0, but changed to 1:2.8 by end (2008). reversal rate two-year-old oysters 40.2%. Specifically, female male 66.1%, which is higher than 21.1%. pattern C. appears go from male⇒female⇒male, and as such determined be rhythmical hermaphroditism.

The use of positron emission tomography (PET) as the initial or sole biomarker β-amyloid (Aβ) brain pathology may inhibit Alzheimer's disease (AD) drug development and clinical due to cost, access, tolerability. We developed a qEEG-ML algorithm predict Aβ among subjective cognitive decline (SCD) mild impairment (MCI) patients, validated it using PET. compared QEEG data between patients with MCI those SCD without PET-confirmed beta-amyloid plaque. resting-state eyes-closed...

More than half of patients with acute ischemic stroke develop post-stroke cognitive impairment (PSCI), a significant barrier to future neurological recovery. Thus, predicting trajectories post-AIS is crucial. Our primary objective determine whether brain network properties from electroencephalography (EEG) can predict function using machine learning approach.We enrolled consecutive who underwent both EEG during the phase and assessments 3 months post-stroke. We preprocessed data eliminate...

Abstract We previously reported that rice bran extract supplement (RBS) administration to mice decreased sleep latency and induced non-rapid eye movement (NREM) via inhibition of the histamine H 1 receptor. Based on this, we performed first clinical trial investigate whether RBS would be beneficial subjects with disturbed sleep. a randomized, double‐blinded, placebo‐controlled, 2-week study. Fifty disturbance were enrolled received either (1,000 mg/day) or placebo. Polysomnography was...