A5075024250- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Laser Applications in Dentistry and Medicine
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- MRI in cancer diagnosis
- Health, psychology, and well-being
- Diet and metabolism studies
- Spaceflight effects on biology
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- RNA regulation and disease
- Stroke Rehabilitation and Recovery
- Optical Imaging and Spectroscopy Techniques
- Migraine and Headache Studies
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Schizophrenia research and treatment
- Mitochondrial Function and Pathology
Boston University
2015-2024
University of Massachusetts Lowell
2022-2024
University of New Hampshire
2022
Harvard University
2022
Tufts University
2022
Beth Israel Deaconess Medical Center
2012-2022
Hanyang University
2005-2016
Objective: To examine effects of four different transcranial, red/near-infrared (NIR), light-emitting diode (tLED) protocols on naming ability in persons with aphasia (PWA) due to left hemisphere (LH) stroke. This is the first study report beneficial from tLED therapy chronic stroke, and parallel changes functional magnetic resonance imaging (fMRI). Materials methods: Six PWA, 2–18 years poststroke, whom 18 treatments were applied (3 × /week, 6 weeks) using LED cluster heads: 500 mW, red...
In the setting of profound ocular blindness, numerous lines evidence demonstrate existence dramatic anatomical and functional changes within brain. However, previous studies based on a variety distinct measures have often provided inconsistent findings. To help reconcile this issue, we used multimodal magnetic resonance (MR)-based imaging approach to provide complementary structural information regarding neuroplastic reorganization. This included gray matter morphometry, high angular...
Patients treated with dialysis have high rates of brain infarcts, atrophy, and white matter disease. There are limited data regarding the presence more subtle damage to matter. In Cognition Dialysis Study, we compared structure using diffusion tensor imaging in hemodialysis (HD) patients individuals without known kidney disease, tract based spatial statistics (TBSS) compare Fractional Anisotropy (FA) Mean Diffusivity (MD). Statistical comparison each overlaid voxel was age controlled a...
Context: Leptin is a key regulator of energy intake and expenditure. Individuals with congenital leptin deficiency demonstrate structural functional brain changes when given leptin. However, whether acquired may operate similarly unclear. Objective: We set out to determine the brains individuals react in similar manner. Design: used magnetic resonance imaging before after short- long-term metreleptin treatment three leptin-sensitive patients hypoleptinemia. Nine healthy women were scanned as...
The mechanism by which only some individuals infected with Mycobacterium tuberculosis develop necrotic granulomas progressive disease while others form controlled that contain the infection remains poorly defined. Mice carrying sst1-suscepible (sst1S) genotype inflammatory lung lesions, similar to human (TB) granulomas, are linked macrophage dysfunction, their congenic counterpart (B6) mice do not. In this study we report (a) sst1S macrophages developed aberrant, biphasic responses TNF...
Background: Chronic traumatic encephalopathy, diagnosed postmortem (hyperphosphorylated tau), is preceded by encephalopathy syndrome with worsening cognition and behavior/mood disturbances, over years. Transcranial photobiomodulation (tPBM) may promote improvements increasing ATP in compromised/stressed cells local blood, lymphatic vessel vasodilation. Objective: Aim 1: Examine cognition, changes Post-tPBM. 2: MRI - resting-state functional-connectivity MRI: salience, central executive,...
The Boston Puerto Rican Health Study (BPRHS) is a longitudinal study following self-identified older adults living in the Greater area. Studies have shown higher prevalence of hypertension (HTN) and type 2 diabetes (T2D) within this ethnic group compared to age-matched non-Hispanic White adults. In study, we investigated associations HTN T2D comorbidity on brain structural integrity cognitive capacity community-dwelling these measures with adult participants (non-Hispanic Hispanic) from...
Summary Purpose: In comparison to temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (TLE‐HS), TLE without HS (TLE‐NH) have a similar clinical course but may result in worse surgical outcome. We investigated whether the features related lack of can be explained by water diffusion abnormalities throughout tensor imaging (DTI) voxel‐based analysis. Methods: Nineteen TLE‐HS (left/right 12:7), 18 TLE‐NH 10:8), and 20 controls were included study. By statistical parametric mapping...
The anterior thalamic nucleus (ATN) is a common target for deep brain stimulation (DBS) the treatment of drug-refractory epilepsy. However, no atlas-based optimal DBS (active contacts) within ATN has been definitively identified. object this retrospective study was to analyze relationship between active contact location and seizure reduction establish an DBS.
The Boston University-based Gulf War Illness Consortium (GWIC) is a multidisciplinary initiative developed to provide detailed understanding of brain and immune alterations that underlie illness (GWI), the persistent multisymptom disorder associated with military service in 1990-1991 War. core GWIC case-control clinical study conducted in-depth evaluation 269 veterans (223 GWI cases, 46 controls) at three U.S. sites included assessments, imaging, neuropsychological testing, analyses broad...
Structural MRI (sMRI) provides valuable information for understanding neurodegenerative illnesses such as Alzheimer's Disease (AD) since it detects the brain's cerebral atrophy. The development of brain networks utilizing single imaging data-sMRI is an understudied area that has potential to provide a network neuroscientific viewpoint on brain. In this paper, we proposed framework constructing sMRI data, followed by extraction signature and important regions interest (ROIs). To construct...
The Tinetti scale is a simple clinical tool designed to predict risk of falling by focusing on gait and stance impairment in elderly persons. Gait also associated with white matter (WM) abnormalities.To test the hypothesis that subjects at for falling, as determined scale, have specific patterns WM abnormalities diffusion tensor imaging.Community-based cohort 125 homebound individuals.Diffusion imaging scans were analyzed using tract-based spatial statistics analysis determine location...
Background Tumor-related white matter change is detected at late stages with magnetic resonance imaging (MRI), when mass effect or prominent edema present.We analyzed if diffusion tensor (DTI) earlier than conventional MRI. MethodsTwenty-six patients gliomas (World Health Organization grade II, 5; III, 12; and IV, 9) within 2 cm from the posterior limb of internal capsule (IC) were studied.Fifteen normal adults enrolled as controls.Fluid attenuation inversion recovery MRI showed a high...
We assessed sex differences in fractional anisotropy (FA) and mean diffusion (MD) of temporal lobe white matter (TLWMFA, TLWMMD), TLWM asymmetry, the relationship between asymmetry FA MD corpus callosum (CCFA, CCMD) using tensor tractography. found both inferior longitudinal fasciculus (ILF); however, it disappeared after statistical adjustments for intracranial volume CCMD variability. superior (SLFFA) ILF (ILFFA, ILFMD) showed leftward asymmetry. In females, indices SLFFA SLF were...