A5068998646- Visual perception and processing mechanisms
- Tactile and Sensory Interactions
- Advanced Neuroimaging Techniques and Applications
- Ophthalmology and Visual Impairment Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Retinal Imaging and Analysis
- Neonatal and fetal brain pathology
- Gaze Tracking and Assistive Technology
- Dementia and Cognitive Impairment Research
- Cerebral Palsy and Movement Disorders
- Brain Tumor Detection and Classification
- Radiomics and Machine Learning in Medical Imaging
- Spatial Neglect and Hemispheric Dysfunction
- Glioma Diagnosis and Treatment
- Multisensory perception and integration
- Stroke Rehabilitation and Recovery
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Epilepsy research and treatment
- Ocular and Laser Science Research
- Visual Attention and Saliency Detection
- Adolescent and Pediatric Healthcare
Harvard University
2016-2025
Gordon Center for Medical Imaging
2022-2025
Massachusetts General Hospital
2022-2025
Massachusetts Eye and Ear Infirmary
2015-2024
University of Bayreuth
2021
Boston University
2010-2014
Deutsches Herzzentrum München
2014
Boston Medical Center
2013
Saitama International Medical Center
2013
Saitama Medical University
2013
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...
Background: Cerebral visual impairment (CVI) is a common sequala of early brain injury, damage, or malformation and one the leading individual causes dysfunction in pediatric populations worldwide. Although patients with CVI are heterogeneous both terms underlying etiology behavioural manifestations, there may be similarities which white matter pathways potentially altered. This exploratory study used diffusion tractography to examine potential differences volume, quantitative anisotropy...
In the setting of profound ocular blindness, numerous lines evidence demonstrate existence dramatic anatomical and functional changes within brain. However, previous studies based on a variety distinct measures have often provided inconsistent findings. To help reconcile this issue, we used multimodal magnetic resonance (MR)-based imaging approach to provide complementary structural information regarding neuroplastic reorganization. This included gray matter morphometry, high angular...
Individuals with cerebral visual impairment (CVI) frequently report challenges face recognition, and subsequent difficulties social interactions. However, there is limited empirical evidence supporting poor recognition in individuals CVI the potential impact on social-emotional quality-of-life factors. Moreover, it unclear whether any represent a broader ventral stream dysfunction. In this web-based study, data from task, glass pattern detection Strengths Difficulties Questionnaire (SDQ)...
Abstract Aim Using a visual psychophysical paradigm, we sought to assess motion and form coherence thresholds as indices of dorsal ventral stream processing respectively, in individuals with cerebral impairment (CVI). We also explored potential associations between assessments brain lesion severity CVI. Method Twenty previously diagnosed CVI (mean age = 17 years 11 months [SD 5 10 months]; mean Verbal IQ 86.42 35.85]) 30 neurotypical development 20 1 month 3 8 110.05 19.34]) participated the...
The thalamus is critical for the relay and modulation of visual information. As such, injury to developing may result in cerebral impairment (CVI). This study investigated quantitative volume reductions compared controls probed association between thalamic severity impairment–related dysfunctions. Thalamic volumes were quantified using T1-weighted magnetic resonance imaging (MRI) data from 23 participants with 42 controls. Nineteen also completed CVI Questionnaire. Cerebral was associated...
Cerebral visual impairment (CVI) is a leading cause of pediatric worldwide. Despite the ramifications on multiple developmental domains and quality life factors, substantial barriers remain for evaluation, diagnosis, treatment, education this growing population children adults. At root lack consensus definition diagnostic criteria CVI narrow ocular/acuity-based classification impairment. This article covers four main issues that need to be urgently addressed make strides toward removing...
Alzheimer's Disease (AD) and mild cognitive impairment (MCI) are associated with widespread changes in brain structure function, as indicated by magnetic resonance imaging (MRI) morphometry 18-fluorodeoxyglucose position emission tomography (FDG PET) metabolism. Nevertheless, the ability to differentiate between AD, MCI normal aging groups can be difficult. Thus, goal of this study was identify combination cerebrospinal fluid (CSF) biomarkers, MRI morphometry, FDG PET metabolism...
Cerebral visual impairment (CVI) is associated with a wide range of perceptual deficits including global motion processing. However, the underlying neurophysiological basis for these impairments remain poorly understood. We investigated processing abilities in individuals CVI compared to neurotypical controls using combined behavioral and multi-modal neuroimaging approach. found that participants had significantly higher mean coherence threshold (determined random dot kinematogram pattern...
Virtual reality (VR) can provide robust assessment of cognitive spatial processing skills in individuals with visual impairment. VR combined objective measures behavioral performance (i.e., eye tracking) affords a high degree experimental control, task flexibility, participant engagement, and enhanced data capture. Individuals impairment typically have difficulties identifying people crowded environments; these may differ depending on the origin Specifically, cortical/cerebral (CVI) show...
DATA REPORT article Front. Syst. Neurosci., 25 February 2016 Volume 10 - | https://doi.org/10.3389/fnsys.2016.00013
Abstract. The present study updates and extends the meta-analysis by Haus et al. (2013) who applied theory of planned behavior (TPB) to analyze gender differences in motivation start a business. We extend this investigating moderating role societal context which business emerges proceeds. results, based on 119 studies analyzing 129 samples with 266,958 individuals from 36 countries, show smaller than original reveal little across cultural regions effects tested model. A meta-regression...
Objective To study age-related characteristics of T1 and T2 relaxation times volume the major salivary glands. Methods Thirty-five subjects (0.5–87 years old) with normal glands were imaged mixed turbo spin-echo pulse sequences at 1.5-T magnetic resonance units. Bilateral parotid, submandibular, sublingual segmented manually. Histograms for each gland generated modeled Gaussian functions every parameter. Results Seventy parotid glands, 52 submandibular 50 histograms analyzed. The exhibited...
Advances in neuroimaging technology have been instrumental uncovering the dramatic neurological changes that result from blindness, as well revealing inner workings of human brain. Specifically, modern imaging techniques enable us to examine how brain adapts and "re-wires" itself a behavior, environment, injury, or disease; process referred neuroplasticity. Following an overview commonly employed techniques, we discuss structural functional neuroplastic associated with profound visual...
Cerebral visual impairment (CVI) is a brain-based disorder associated with injury and/or maldevelopment of central pathways. Visuospatial processing impairments are cardinal feature the complex clinical profile individuals CVI. Here, we assessed visuospatial abilities using classic conjunction search task. Twenty-three (23) previously diagnosed CVI (mean age 18.55 years ± 4.98 SD) and 37 controls neurotypical development 21.11 4.56 participated in study. Subjects were instructed to for...
Objective: In Alzheimer's FDG PET research, the choice of reference region for normalization and use partial volume correction are inconsistent have not been studied in a large multi-center study. Herein, we identified which provided highest degree discrimination between subjects who were classified as normal aging, mild cognitive impairment, or disease. The effects using either gray matter mask cortical thickness subcortical residuals also examined. Methods: Stepwise logistic regression...