Marina Boccardi
A5015109247- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Neurological Disease Mechanisms and Treatments
- Cancer-related cognitive impairment studies
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Computational Drug Discovery Methods
- Memory and Neural Mechanisms
- Neurobiology of Language and Bilingualism
- Delphi Technique in Research
- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Brain Tumor Detection and Classification
- Intracerebral and Subarachnoid Hemorrhage Research
- Frailty in Older Adults
- Meta-analysis and systematic reviews
- Neuroscience and Neuropharmacology Research
- Health, Environment, Cognitive Aging
German Center for Neurodegenerative Diseases
2021-2024
University of Rostock
2023-2024
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2023-2024
University of Geneva
2016-2021
Centro San Giovanni di Dio Fatebenefratelli
2011-2020
Rostocker Zentrum zur Erforschung des Demografischen Wandels
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2006-2019
University of Brescia
2015-2016
Azienda Ospedaliera Ospedale Maggiore
2016
International Flame Research Foundation
2016
Recommendations for using fluorodeoxyglucose positron emission tomography (FDG-PET) to support the diagnosis of dementing neurodegenerative disorders are sparse and poorly structured.Twenty-one questions on diagnostic issues semi-automated analysis assist visual reading were defined. Literature was reviewed assess study design, risk bias, inconsistency, imprecision, indirectness effect size. Critical outcomes sensitivity, specificity, accuracy, positive/negative predictive value, area under...
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research a variety populations and diseases on the structure function hippocampal subfields subdivisions parahippocampal gyrus. Because many extant highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, Hippocampal Subfields Group was formed as an international collaboration with aim developing harmonized protocol for manual subregions MRI. In...
Abstract Background This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, define standard operating procedures for magnetic resonance (MR)‐based manual hippocampal segmentation. Methods The panel received questionnaire regarding procedures. Quantitative information was supplied allow evidence‐based answers. A recursive anonymous Delphi procedure used achieve convergence. Significance agreement among...
Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer's disease (AD). Nonetheless, different protocols provide up to 2.5-fold volume differences. Here we surveyed th
Abstract Background The European Alzheimer's Disease Consortium and Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard truth to train new tracers, validate automated algorithms. Training requires large representative data sets segmented hippocampi. This work aims produce set HarP labels for proper training certification tracers Methods Sixty‐eight 1.5 T 67 3...
<h3>Importance</h3> Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility debated. <h3>Objective</h3> To evaluate the incremental diagnostic value of florbetapir F 18 addition to routine assessment patients evaluated for cognitive impairment. <h3>Design, Setting, Participants</h3> The Incremental Diagnostic Value...
Regulatory qualification of a biomarker for defined context use provides scientifically robust assurances to sponsors and regulators that accelerate appropriate adoption biomarkers into drug development.The Coalition Against Major Diseases submitted dossier the Scientific Advice Working Party European Medicines Agency requesting opinion on hippocampal volume as enriching clinical trials in subjects with mild cognitive impairment, incorporating scientific rationale, literature review de novo...
Abstract Objective The pathologic validation of European Alzheimer's Disease Consortium Alzheimer’s Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Methods Temporal lobes nine disease (AD) and seven cognitively normal subjects were scanned post‐mortem at 7 Tesla. volumes obtained with HarP. Six‐micrometer‐thick hippocampal slices stained for amyloid beta (Aβ), tau, cresyl violet. subfields manually traced. Neuronal counts, Aβ, tau burden each subfield...
Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim develop a harmonized protocol based expert consensus histological evidence. Methods Our international working group, funded by EU Joint Programme–Neurodegenerative Disease Research (JPND), is toward production reliable, validated, regions. The group uses novel postmortem...