A5004690805- Radio Frequency Integrated Circuit Design
- Semiconductor Quantum Structures and Devices
- Superconducting and THz Device Technology
- Microwave Engineering and Waveguides
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Semiconductor materials and devices
- Advanced Neuroimaging Techniques and Applications
- Acoustic Wave Resonator Technologies
- Shoulder Injury and Treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Orthopedic Surgery and Rehabilitation
- Advanced Power Amplifier Design
- Memory and Neural Mechanisms
- Hip disorders and treatments
- GaN-based semiconductor devices and materials
- Single-cell and spatial transcriptomics
- Orthopedic Infections and Treatments
- Radar Systems and Signal Processing
University of California, Los Angeles
2017-2021
University of Southern California
1989-2021
Ronald Reagan UCLA Medical Center
2018
Hospital for Special Surgery
2008-2018
Hudson Simulation Service
2018
Metron (United States)
2006
Redondo Optics (United States)
1993-2005
TRW Automotive (United States)
1995
Southern California University for Professional Studies
1989
The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behaviour, natural history many neurological neuropsychiatric disorders. Classically, this conceptualized contain three information channels: motor, limbic associative1-4. Yet three-channel view cannot explain myriad functions basal ganglia. We previously subdivided dorsal striatum into 29...
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated interpreted
The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive sensorimotor behaviors. However, it remains unclear how descending input arising from higher-order associative areas coordinate with SC networks influence its outputs. Here, we construct comprehensive map all cortico-tectal projections identify four collicular zones differential inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) lateral (SC.l). Further, delineate the...
The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. Here, we apply machine-learning based computational informatics analysis techniques results circuit-tracing experiments create foundational,...
Abstract Objective The pathologic validation of European Alzheimer's Disease Consortium Alzheimer’s Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Methods Temporal lobes nine disease (AD) and seven cognitively normal subjects were scanned post‐mortem at 7 Tesla. volumes obtained with HarP. Six‐micrometer‐thick hippocampal slices stained for amyloid beta (Aβ), tau, cresyl violet. subfields manually traced. Neuronal counts, Aβ, tau burden each subfield...
Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes 9 dementia (AD) 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at Tesla. extracted hippocampal volumes radial distances using automated segmentation techniques. slices stained for beta (Aβ), tau, cresyl violet to evaluate neuronal counts. The subfields, CA1, CA2, CA3, CA4, subiculum manually traced so that counts, Aβ,...
Abstract An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits systems can be integrated interpreted. Here, through collaborative effort from the Brain Initiative Cell Census Network (BICCN), we derive comprehensive cell type-based description of one structure - primary motor cortex upper limb area (MOp-ul) mouse. Applying state-of-the-art...
This paper presents the development of a 140-GHz monolithic low noise amplifier (LNA) using 0.1-μm pseudomorphic InAlAs-InGaAs-InP HEMT technology. A two-stage single-ended LNA has been designed, fabricated and tested. It exhibits measured small signal gain 9 dB at 142 GHz, more than 5-dB from 138-145 GHz. is highest frequency ever reported three terminal devices.
Background Navigation allows for determination of the mechanical axis lower extremity during high tibial osteotomy (HTO) procedures. The objectives this study were to (1) evaluate reliability noninvasive registration with an image-free navigation system HTO and (2) determine accuracy monitor changes in limb alignment as compared measured a novel 3-dimensional computed tomography method. Hypothesis Navigated demonstrates good all 3 planes. Study Design Descriptive laboratory study. Methods...
ABSTRACT The cortico-basal ganglia-thalamic loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behavior, natural history many neurological neuropsychiatric diseases. Classically, basal ganglia conceptualized contain three primary information output channels: motor, limbic, associative. However, given roughly 65 cortical areas two dozen thalamic nuclei that feed into dorsal striatum, a...
ABSTRACT Finite element (FE) models are frequently used to assess mechanical interactions between orthopedic implants and surrounding bone. However, FE studies often limited by the small number of bones that modeled; use normal do not reflect altered bone density distributions result from osteoarthritis (OA); application simplified load cases usually based on peak forces without consideration tibiofemoral kinematics. To overcome these limitations, we undertook an integrated approach...
A monolithic V-band VCO using InP-based HBT technology has been designed, fabricated, and tested. This delivers a peak output power of 4 dBm at center frequency 62.4 GHz with tuning range 300 MHz. The measured phase noise shows -78 dBc/Hz 100 kHz offset -104 1 MHz offset. To our knowledge, this is the highest fundamental-mode oscillator ever reported bipolar transistors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A novel multifunctional balanced switching low-noise amplifier (BSLNA) which can be used as a amplifier, switch, or broad-band 180/spl deg/ phase shifter is proposed. Two monolithic BSLNA's at Ka- and W-band frequencies are demonstrated using the 0.1 /spl mu/m pseudomorphic (PM) InP- GaAs-based HEMT technologies, respectively. Potential applications of BSLNA in on-off keying (OFK) binary phase-shift (BPSK) communication systems input switch for Dicke-switched radiometer systems. The...
We report the design and performance of state-of-the-art V-band MMIC LNA's using 0.1- mu m gate length pseudomorphic In/sub 0.60/Ga/sub 0.40/As/In/sub 0.52/Al/sub 0.48/As/InP HEMT's. The three-stage LNA demonstrated an average 3.0 dB noise figure between 56-64 GHz with 24-25.5 associated gain a 2.7 measured at 62 GHz. Furthermore, DC power dissipation this circuit was only 19.5 mW which is less than one-third InGaAs/AlGaAs/GaAs HEMT versions. These results demonstrate excellent potential InP...
The authors report a Q-band two-stage MMIC low-noise amplifier based on 0.1- mu m pseudomorphic InAlAs-InGaAs-InP HEMT technology. has achieved an average noise figure of 2.3 dB with associated gain 25 over the band from 43 to 46 GHz. This is best result ever reported for monolithic at this frequency range. In addition, InP-based consumes only 12 mW, which least three times lower than GaAs-based counterpart, indicating that HEMTs are well suited very high density integration or application...
The development of W-band monolithic low noise amplifiers (LNAs) using a fully passivated 0.1 µm pseudomorphic InAlAs/InGaAs/InP HEMT technology is presented. Both wafer passivation and stabilisation bakes have been introduced, for the first time, to InP MMIC process make it more suitable production. A three-stage single-ended 94 GHz LNA shows measured figure 3.3 dB 20 associated gain. 2.3 achieved single-stage at GHz. These results represent state-of-the-art performance LNAs this frequency....
This paper discusses the development of a large scale W-band focal plane array (FPA) for passive radiometric imaging application. The goal is to develop 40/spl times/26 (1040-pixels) FPA cover 15/spl deg//spl times/10/spl deg/ instantaneous field-of-view. Each receiver consists single direct detection MMIC which high gain, wide bandwidth switched LNA with integrated Schottky barrier diode detector. A 1/spl times/4 module, employing linearly tapered slot antenna, used as basic building block...
W-band MMIC (monolithic microwave integrated circuit) direct-detection receivers for passive millimeter-wave imaging applications have been demonstrated. These were developed using InGaAs HEMT (high electron mobility transistor)-based W-based LNA (low-noise amplifier) and preamplified detector MMICs. The first receiver uses a 50-dB-gain, 6-dB-noise-figure amplifier Schottky-barrier-diode waveguide detector. four LNAs. second consists of two three-stage LNAs an chip. Individual with camera...
A wavelength-multiplexed optical interconnection system in which the electrical power is provided by an source discussed. The and data signals, operating at two different wavelengths, are multiplexed onto a single fiber local terminal, demultiplexed remote terminal. then converted to array of photovoltaic cells, providing bias control data-detection circuit. operates 45 Mb/s, receiver dissipates 2.6 mW, there negligible crosstalk between channels.< <ETX...
We have demonstrated a monolithic W-band six-stage low noise amplifier/detector, using 0.1 /spl mu/m passivated pseudomorphic Al/sub 0.25/Ga/sub 0.75/As/In/sub 0.22/Ga/sub 0.78/As/GaAs HEMT technology. The front-end LNA, over the band from 85 to 96 GHz has achieved an average small signal gain of 40 dB which is highest value ever reported for MMIC operating in W-band. measured minimum resolvable temperature about 1.6 K, where dominant source attributed be 1/f monolithically integrated...
A monolithic W-band power amplifier has been developed to promote the output performance, This two-stage balanced demonstrated a small signal gain of 7 dB and an 175 mW at 90 GHz, which represents state-of-the-art performance for this frequency. chip is fabricated using 0.1-/spl mu/m AlGaAs-InGaAs-GaAs pseudomorphic HEMT MMIC production process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>