A5006359053- Rheumatoid Arthritis Research and Therapies
- Smoking Behavior and Cessation
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Ethics in Clinical Research
- School Health and Nursing Education
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Health and Wellbeing Research
- Health Literacy and Information Accessibility
- Musculoskeletal synovial abnormalities and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Neuroimaging Techniques and Applications
- Cervical Cancer and HPV Research
- COVID-19 and Mental Health
- Orthopedic Surgery and Rehabilitation
- Biomedical Ethics and Regulation
- Pharmaceutical industry and healthcare
- Functional Brain Connectivity Studies
- Viral Infections and Immunology Research
- Interpreting and Communication in Healthcare
University of California, Los Angeles
2016-2025
Cedars-Sinai Medical Center
2022
Florida College
2022
University of Florida
2022
Weatherford College
2022
Foundation for Psychocultural Research
2020
UCLA Health
2014-2017
Hudson Institute
2017
John Wiley & Sons (United States)
2017
Sigma Theta Tau International
2017
Abstract Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim understand the host immunologic and microbial features of COVID-19 in recipients by leveraging a prospective multicenter cohort 86 age- sex-matched with 172 non-transplant controls. find that higher nasal SARS-CoV-2 viral abundance impaired clearance, lower anti-spike IgG levels. In addition, exhibit...
<b><i>Background:</i></b> Behavioral symptoms are common in both mild cognitive impairment (MCI) and Alzheimer's disease (AD). <b><i>Methods:</i></b> We analyzed the Neuropsychiatric Inventory Questionnaire data of 3,456 MCI 2,641 AD National Coordinating Center database participants. Using factor analysis logistic regression we estimated effects age, sex, race, education, Mini-Mental State Examination, functional impairment, marital status...
To investigate the relationship between Krebs von den Lungen 6 (KL-6) and CCL18 levels severity progression of systemic sclerosis (SSc)-related interstitial lung disease (ILD).Patients enrolled in Scleroderma Lung Study II (cyclophosphamide [CYC] versus mycophenolate mofetil [MMF]) were included. Baseline 12-month plasma samples analyzed by enzyme-linked immunosorbent assay to assess KL-6 levels. The forced vital capacity (FVC) diffusing for carbon monoxide (DLco) measured every 3 months....
Abstract Objective The pathologic validation of European Alzheimer's Disease Consortium Alzheimer’s Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Methods Temporal lobes nine disease (AD) and seven cognitively normal subjects were scanned post‐mortem at 7 Tesla. volumes obtained with HarP. Six‐micrometer‐thick hippocampal slices stained for amyloid beta (Aβ), tau, cresyl violet. subfields manually traced. Neuronal counts, Aβ, tau burden each subfield...
Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like natural killer (NK) cells expressing NKG2C and lacking FcεRIγ are established during CMV infection. Additionally, CD8
Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes 9 dementia (AD) 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at Tesla. extracted hippocampal volumes radial distances using automated segmentation techniques. slices stained for beta (Aβ), tau, cresyl violet to evaluate neuronal counts. The subfields, CA1, CA2, CA3, CA4, subiculum manually traced so that counts, Aβ,...
Abstract Purpose To evaluate a brief educational program about smoking cessation on the frequency of nurses’ interventions with smokers, and impact status outcomes. Design Prospective, single group design prestudy 3 months post‐study data. Methods Nurses in Czech Republic attended hospital‐based 1‐hr programs helping smokers quit. They completed surveys (i.e., always, usually, sometimes, rarely, never) their patients using five A's framework ask, advise, assess, assist, arrange), attitudes...
Research has revealed that manifest Alzheimer's disease (AD) dementia is preceded by preclinical and prodromal phases during which pathology accumulating but function remains intact. This understanding concern disease-modifying interventions initiated at the stage may come too late in neurodegenerative process to be successful led a paradigm shift AD clinical trials. trials now enroll patients with mild cognitive impairment (MCI) persons no symptoms. Trial designs are similar those enrolling...
Tobacco use is the leading cause of preventable disease and death in Europe worldwide. Nurses, if properly educated, can contribute to decreasing burden tobacco region by helping smokers quit smoking.To assess: (a) feasibility an online program educate nurses Czech Republic Poland on evidence-based smoking cessation interventions for patients (b) self-reported changes practices related consistently (usually or always) providing smokers, before 3 months after participation program.A...
Progressive gray matter (GM) atrophy is a hallmark of multiple sclerosis (MS). Cognitive impairment has been observed in 40%-70% MS patients and linked to GM atrophy. In phase 2 trial estriol treatment women with relapsing-remitting (RRMS), higher levels correlated greater improvement on the paced auditory serial addition test (PASAT) imaging revealed sparing localized estriol-treated compared placebo-treated patients. To better understand significance this sparing, current study explored...
Abstract Objective To examine whether a weight loss intervention programme improves RA disease activity and/or musculoskeletal ultrasound synovitis measures in obese patients. Methods We conducted proof-of-concept, 12-week, single-blind, randomized controlled trial of patients (BMI ≥ 30) with 28-joint DAS (DAS28) 3.2 and evidence power Doppler synovitis. Forty were to the diet (n = 20) or control group 20). Diet consisted hypocaloric 1000–1500 kcal/day high protein meal replacements....
Abstract Aims To evaluate a web‐based educational smoking cessation programme on changes in the frequency of hospital‐based nurses’ self‐reported interventions to help smokers quit using 5 As (i.e. Ask, Advise, Assess, Assist, Arrange), reduce exposure second‐hand smoke and change attitudes about involvement tobacco control. Background Few nurses China support smokers’ attempts evidence‐based based As. Limited knowledge is barrier intervention. Web‐based programs have potential reach large...
Abstract Aims To describe the self‐reported frequency of Chinese nurses’ interventions to help smokers quit, using 5 As (i.e. Ask, Advise, Assess, Assist, Arrange), attitudes towards tobacco control and differences in consistency by demographic professional characteristics prior an educational intervention increase support for quit efforts. Background Tobacco use is leading cause preventable death China; quitting smoking reduces health risks premature death. The China Cessation Treatment...
Tobacco is the leading cause of cancer in Czech Republic. More than one-third population older 15 years smokes, including many nurses. Most smokers want to quit, but extent nurses' involvement tobacco cessation unknown.The purposes this study are describe frequency interventions helping examine their attitudes and skills, explore relationship smoking status level intervention.A convenience sample nurses Republic completed a survey about according 5As for dependence treatment (i.e., ask,...
To evaluate an educational programme about nurses' role in tobacco dependence treatment, and its webcast component, on the long-term impact of increasing frequency self-reported changes practice related to delivery smoking cessation interventions.Healthcare professionals' knowledge evidence-based treatment using 5As framework (Ask use, Advise users quit, Assess willingness Assist making a quit plan Arrange for follow-up, including referral quitline) is essential increase rates United...
Persons at risk for autosomal dominant neurodegenerative diseases provide the opportunity to efficiently test preventive interventions. Only a minority of such persons, however, choose undergo revealing genetic testing, presenting challenge enrollment. Thirty-four preclinical Latinos (n = 26) and non-Latinos familial Alzheimer's disease (FAD) unaware their status were administered questionnaire exploring interest in undergoing testing baseline context eligibility four prevention trials...
Abstract Background Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in management of rheumatoid arthritis (RA) patients. This study evaluated tofacitinib response by MSUS/MBDA scores assessed whether baseline or their early changes predict later clinical response. Methods Twenty-five RA patients treated with were at baseline, 2, 6 12-weeks. Power doppler (PDUS) gray scale (GSUS) scores, MBDA score, index (CDAI),...
Numbering about 90,000, nurses represent the largest group of health care providers in Czech Republic. Therefore, can make a significant impact treatment tobacco dependence, particularly applying brief interventions to smokers.During 2014, 279 from Republic participated an e-learning education programme consisting two Webcasts with additional web-based resources smoking cessation relation and options daily clinical practice, regarding intervention methods. Before viewing programme, three...
1. World Health Organization. Nursing and midwifery. https://www.euro.who.int/en/he.... Accessed August 16, 2017. Google Scholar
Active rheumatoid arthritis (RA) is associated with increased cardiovascular risk and impaired function of high-density lipoprotein (HDL). Previous work suggests that HDL may become dysfunctional through oxidative modifications within the RA joint. The current evaluates an association synovial power doppler ultrasound signal (PDUS) structure. Two open-label clinical therapeutic studies using PDUS as a disease outcome measure were included in this analysis, including 12-month trial...
Background An anal histological high‐grade squamous intraepithelial lesion (hHSIL) is an cancer precursor. Experts recommend Dacron swab cytology as a primary screen for hHSILs, especially among human immunodeficiency virus–infected and –uninfected men who have sex with (MSM). Studies shown that inaccurately predicts hHSILs results in unnecessary diagnostic procedures. Nylon‐flocked (NF) swabs been to trap pathogens cells well. Thus, this study compared test characteristics of using NF...