A5030884181- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Ischemia and Reperfusion
- Renin-Angiotensin System Studies
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Signaling Pathways in Disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protease and Inhibitor Mechanisms
Fujieda Municipal General Hospital
2022-2024
University of Yamanashi
2013-2022
University of Yamanashi Hospital
2008-2020
University of California, Los Angeles
2017-2019
New Tokyo Hospital
2017
Shionogi (Japan)
2013
Tokyo Metropolitan Institute of Medical Science
2013
American Heart Association
2013
Ministry of Education, Culture, Sports, Science and Technology
2010
University of California, San Francisco
2000
Background: Contrast-enhanced ultrasound (CEUS) in the carotid artery has potential as a technique for imaging plaque neovascularization. This study examined whether CEUS could provide information on severity and instability of coronary disease (CAD). Methods Results: A total 304 patients with CAD underwent examination artery. Intraplaque neovascularization was identified basis microbubbles within graded as: G0, not visible; G1, moderate; or G2, extensive microbubbles. The complexity extent...
To investigate the relationship between Krebs von den Lungen 6 (KL-6) and CCL18 levels severity progression of systemic sclerosis (SSc)-related interstitial lung disease (ILD).Patients enrolled in Scleroderma Lung Study II (cyclophosphamide [CYC] versus mycophenolate mofetil [MMF]) were included. Baseline 12-month plasma samples analyzed by enzyme-linked immunosorbent assay to assess KL-6 levels. The forced vital capacity (FVC) diffusing for carbon monoxide (DLco) measured every 3 months....
We determined time course of stabilization echolucent carotid plaques by statin therapy in patients with acute coronary syndrome (ACS). Treatment 4 mg/d pitavastatin (n = 33) or placebo 32) was initiated within 3 days after onset ACS 65 plaque. Vulnerable were assessed measuring plaque echolucency using ultrasound integrated backscatter (IBS) analysis before and 1 month treatment all patients. The calibrated IBS value (intima-media minus adventia IBS) vulnerable favorably changed at both...
This study examined the predictive value of remnant lipoprotein levels for cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD) and low-density cholesterol (LDL-C) <70 mg/dL on statin treatment.
Because metabolic syndrome is associated with cardiovascular diseases, its association the risk of paroxysmal atrial fibrillation (PAF) and/or flutter (PAFL) was examined in present study.A prospective analysis performed 592 consecutive hospitalized patients without obvious structural heart diseases. Sinus rhythm confirmed by electrocardiography all patients. PAF/PAFL occurred 32 (5%) and 127 (21%) enrolled. 12 (9%) syndrome, but only 20 (4%) (p=0.02). Multivariate logistic regression showed...
Abstract Secretory phospholipase A2 (sPLA2) plays a critical role in the genesis of lung inflammation through proinflammatory eicosanoids. A previous vitro experiment showed possible cell surface receptor for sPLA2 (PLA2R) clearance extracellular sPLA2. PLA2R and groups IB X are expressed lung. This study examined pathogenic airway using PLA2R-deficient (PLA2R−/−) mice. Airway was induced by immunosensitization with OVA. Compared wild-type (PLA2R+/+) mice, PLA2R−/− mice had significantly...
AimsChronic depletion of myocardial glutathione (GSH) may play a role in cardiac remodelling and dysfunction. This study examined the relationship between chronic GSH failure induced by pressure overload mice lacking modifier subunit (GCLM) glutamate–cysteine ligase, rate-limiting enzyme for synthesis. In addition, we association idiopathic dilated cardiomyopathy (DCM) humans –588C/T polymorphism GCLM gene, which reduces plasma levels GSH.
AimsGroup V secretory phospholipase A2 (sPLA2-V) is highly expressed in the heart. This study examined (i) role of sPLA2-V myocardial ischaemia–reperfusion (I/R) injury and (ii) cooperative action cytosolic PLA2 (cPLA2) I/R injury, using knockout (sPLA2V−/−) mice.
Group IVA cytosolic phospholipase A(2) (cPLA(2)α), which preferentially cleaves arachidonic acid from phospholipids, plays a role in apoptosis and tissue injury. Downstream signals response to tumor necrosis factor (TNF)-α, mediator of myocardial ischemia-reperfusion (I/R) injury, involve cPLA(2)α activation. This study examined the potential its mechanistic link with TNF-α I/R injury using knockout (cPLA(2)α(-/-)) mice. Myocardial was created 10-wk-old male mice by 1 h ligation left...
Recent evidence indicates that the biological effects of secretory phospholipase A2 (sPLA2) cannot be fully explained by its catalytic activity. A cell surface receptor for sPLA2 (PLA2 1 [PLA2R]) and high-affinity ligands (including sPLA2-IB, sPLA2-IIE, sPLA2-X) are expressed in infarcted myocardium.This study asked whether PLA2R might play a pathogenic role myocardial infarction (MI) using mice lacking (PLA2R(-/-)).MI was induced permanent ligation left coronary artery. PLA2R(-/-) exhibited...
The renin-angiotensin system (RAS) is implicated in the development of hypertensive glomerulosclerosis. However, no experimental evidence exists that clearly demonstrates activation glomerular RAS nephropathy. We used stroke-prone spontaneously rats (SHRSP) to examine whether components are increased glomeruli SHRSP and this increase leads an mRNA levels for transforming growth factor-beta1 (TGF-beta1).We examined sequential changes urinary albumin excretion (UAE), morphology, expression...
Phospholipase A 2 receptor 1 (PLA R) mediates collagen‐dependent migration. The mechanisms by which PLA R interacts with collagen remain unclear. We produced HEK293 cells expressing full‐length wild‐type or a truncated that lacks fibronectin‐like type II (FNII) domains several regions of C‐type lectin‐like domain (CTLD). show the CTLD1–2 as well FNII are responsible for binding to and Thus, multiple extracellular portion participate in responses collagen. These data suggest potentially new...
AimsGlutamate-cysteine ligase (GCL), a rate-limiting enzyme for glutathione (GSH) synthesis, is composed of catalytic and modifier subunits. This study examined the pathogenic role GCL subunits (GCLM) in myocardial ischaemia–reperfusion (I/R) injury using mice lacking GCLM (GCLM−/−).
Although plasminogen activator inhibitor-1 (PAI-1) is abundantly expressed in infarcted myocardium, the pathogenic role of myocardial PAI-1 remains unknown. This study examined whether lesion contributes to coronary endothelial dysfunction and left ventricular (LV) patients with acute infarction (AMI).Plasma levels activity tissue-plasminogen (tPA) antigen were measured 2 weeks 6 months after MI by ELISA plasma obtained from aortic root (AO) anterior interventricular vein (AIV) 28 a first...
The role of stromal cell-derived factor-1α (SDF-1α) expressed in infarcted myocardium is unknown humans. We examined whether SDF-1α produced an myocardial lesion may play a left ventricle (LV) remodeling and dysfunction patients with acute infarction (AMI). measured levels plasma obtained from aortic root (AO) anterior interventricular vein (AIV) the early phase (2 wk after MI) chronic (6 mo 80 MI. An increment level AO to AIV, reflecting release myocardium, was more frequent MI [n = 52...