A5055325607- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
University of Yamanashi
2016-2025
University of Yamanashi Hospital
2006-2024
Nagasaki University
2018
University of Nagasaki
2017
Hokkaido University
1975-2014
Shionogi (Japan)
2008-2013
Tokyo Metropolitan Institute of Medical Science
2013
Saint Joseph’s Translational Research Institute
2010-2013
The Nakamura Hajime Eastern Institute
2012-2013
Saint Joseph's Hospital
2010-2013
Fibroblasts or their conditioned medium stimulated invasion by squamous cell carcinoma cells. The fibroblast-derived activity responsible for increased is the hepatocyte growth factor/scatter factor (HGF/SF), a ligand c-Met receptor. HGF/SF migration of cells on various extracellular matrix substrates but did not alter adhesion efficiency nor integrin expression. motility in two step process: initially spread rapidly and formed focal adhesions, then they disassembled these condensations,...
Adiponectin, an adipocyte-derived protein, has cardioprotective actions. We elucidated the role of adiponectin receptors AdipoR1 and AdipoR2 in effects on endothelin-1 (ET-1)-induced hypertrophy cultured cardiomyocytes, we examined expression normal infarcted mouse hearts. Recombinant full-length suppressed ET-1-induced increase cell surface area [(3)H]leucine incorporation into cardiomyocytes compared with cells treated ET-1 alone. Transfection small interfering RNA (siRNA) specific for or...
Background: Contrast-enhanced ultrasound (CEUS) in the carotid artery has potential as a technique for imaging plaque neovascularization. This study examined whether CEUS could provide information on severity and instability of coronary disease (CAD). Methods Results: A total 304 patients with CAD underwent examination artery. Intraplaque neovascularization was identified basis microbubbles within graded as: G0, not visible; G1, moderate; or G2, extensive microbubbles. The complexity extent...
We determined time course of stabilization echolucent carotid plaques by statin therapy in patients with acute coronary syndrome (ACS). Treatment 4 mg/d pitavastatin (n = 33) or placebo 32) was initiated within 3 days after onset ACS 65 plaque. Vulnerable were assessed measuring plaque echolucency using ultrasound integrated backscatter (IBS) analysis before and 1 month treatment all patients. The calibrated IBS value (intima-media minus adventia IBS) vulnerable favorably changed at both...
Background— Group X secretory phospholipase A 2 (sPLA -X) has the most potent hydrolyzing activity toward phosphatidylcholine and elicits a marked release of arachidonic acid among several types sPLA . -X is expressed in neutrophils, but its pathogenic role remains unclear. Methods Results— We generated mice that lack studied their response to myocardial ischemia/reperfusion. The −/− had significant reduction infarct size decrease myeloperoxidase compared with +/+ mice. Myocardial was also...
Water quality monitoring and microbial risk assessment are important to ensure safe water for drinking, recreational, agricultural purposes. In this study, we applied a microfluidic quantitative PCR (MFQPCR) approach simultaneously quantify multiple waterborne pathogens in natural freshwater lake Hokkaido, Japan, from April November, 2012. Tens of thousands geese stopped over at during their migration spring fall. Because is used irrigation the surrounding area, assessed infection risks...
This study examined the predictive value of remnant lipoprotein levels for cardiovascular events (CVEs) in patients with stable coronary artery disease (CAD) and low-density cholesterol (LDL-C) <70 mg/dL on statin treatment.
Background: Reduced insulin secretion is linked to diabetes and cardiovascular disease (CVD), but its role in non-diabetic CVD patients unclear. The homeostasis model assessment of β-cell function (HOMA-β) measures pancreatic function. This study investigated the association between HOMA-β adverse events patients.
The psoas muscle area (PMA) and rectus femoris (RFMA) have been used to estimate whole-body mass in elderly patients. However, it is unclear whether combining these measurements can improve the predictive ability of traditional risk factors for adverse clinical events patients with aortic valve stenosis (AVS). We analyzed data from 153 AVS who underwent transcatheter replacement (TAVR), measured PMA RFMA using computed tomography (CT) before procedure. This study assessed a composite...
Because metabolic syndrome is associated with cardiovascular diseases, its association the risk of paroxysmal atrial fibrillation (PAF) and/or flutter (PAFL) was examined in present study.A prospective analysis performed 592 consecutive hospitalized patients without obvious structural heart diseases. Sinus rhythm confirmed by electrocardiography all patients. PAF/PAFL occurred 32 (5%) and 127 (21%) enrolled. 12 (9%) syndrome, but only 20 (4%) (p=0.02). Multivariate logistic regression showed...
A statistical analysis of 323 patients with facial fractures treated as in-patients by the Department Otolaryngology and Maxillofacial Surgery University Tennessee during period 1966 through 1970 is presented. Operations for fracture comprised 2% total operative procedures at hospital. Intended violence was far most common cause injury (59%). Associated injuries were present in 30% cases. Consultation obtained from other services 50% Satisfactory results cosmetic functional viewpoints 86%.
Abstract Secretory phospholipase A2 (sPLA2) plays a critical role in the genesis of lung inflammation through proinflammatory eicosanoids. A previous vitro experiment showed possible cell surface receptor for sPLA2 (PLA2R) clearance extracellular sPLA2. PLA2R and groups IB X are expressed lung. This study examined pathogenic airway using PLA2R-deficient (PLA2R−/−) mice. Airway was induced by immunosensitization with OVA. Compared wild-type (PLA2R+/+) mice, PLA2R−/− mice had significantly...
AimsChronic depletion of myocardial glutathione (GSH) may play a role in cardiac remodelling and dysfunction. This study examined the relationship between chronic GSH failure induced by pressure overload mice lacking modifier subunit (GCLM) glutamate–cysteine ligase, rate-limiting enzyme for synthesis. In addition, we association idiopathic dilated cardiomyopathy (DCM) humans –588C/T polymorphism GCLM gene, which reduces plasma levels GSH.
Background:After acute coronary syndrome (ACS), there is a high risk of recurrent cardiovascular events. Triglyceride-rich lipoproteins influence residual in patients taking statin. This study examined the predictive value remnant lipoprotein level for secondary events treated with statins after ACS.Methods and Results:A total 190 ACS were enrolled study. The serum (remnant-like particle cholesterol; RLP-C) was measured using an immunoseparation method. All followed prospectively maximum...