A5036667749- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Asthma and respiratory diseases
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Acute Myocardial Infarction Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Risk Factors
- Proteoglycans and glycosaminoglycans research
- Inhalation and Respiratory Drug Delivery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Protease and Inhibitor Mechanisms
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Signaling Pathways in Disease
University of Yamanashi
2015-2025
University of Yamanashi Hospital
2019-2024
Fukushima Medical University
2012-2021
Asahi General Hospital
2020
American Heart Association
2013
Shizuoka General Hospital
2007
Kobe Children's Hospital
1994-1995
Osaka Police Hospital
1986
Background: Reduced insulin secretion is linked to diabetes and cardiovascular disease (CVD), but its role in non-diabetic CVD patients unclear. The homeostasis model assessment of β-cell function (HOMA-β) measures pancreatic function. This study investigated the association between HOMA-β adverse events patients.
The psoas muscle area (PMA) and rectus femoris (RFMA) have been used to estimate whole-body mass in elderly patients. However, it is unclear whether combining these measurements can improve the predictive ability of traditional risk factors for adverse clinical events patients with aortic valve stenosis (AVS). We analyzed data from 153 AVS who underwent transcatheter replacement (TAVR), measured PMA RFMA using computed tomography (CT) before procedure. This study assessed a composite...
Objective Since the term "combined pulmonary fibrosis and emphysema" (CPFE) was first proposed, co-existence of emphysema (PE) has drawn considerable attention. However, conflicting results on clinical characteristics patients with both PE have been published because lack an exact definition CPFE. The goal this study thus to clarify phenotypes idiopathic interstitial pneumonia (IIP) PE. Methods We retrospectively analyzed IIP who had admitted our hospital. Their chest high-resolution...
Background. Syndecan-4 is a transmembrane heparan sulfate proteoglycan expressed in variety of cells, and glycosaminoglycan side chains syndecan-4 bind to several proteins, suggesting biological functions. However, the role acute bacterial pneumonia has not yet been elucidated.
Background: Decorin is a small leucine-rich repeat proteoglycan that plays critical role in collagen fibrillogenesis, and regulates inflammation, wound healing angiogenesis. In idiopathic pulmonary fibrosis (IPF), decorin expressed fibrotic lesions; furthermore, intratracheal gene transfer of has been demonstrated to inhibit bleomycin-induced fibrosis. Although these results suggest the fibrosis, acute exacerbation interstitial pneumonia (AE-IIP) not clarified detail. Thus, goal this study...
Reactive oxygen species (ROS) increase during adipogenesis and in obesity. Oxidants react with cysteine residues of proteins to form glutathione (GSH) adducts, S-glutathionylation, that are selectively removed by glutaredoxin-1 (Glrx). We have previously reported Glrx knockout mice had increased protein S-glutathionylation developed obesity an unknown mechanism. In this study, we demonstrated 3T3L1 adipocytes differentiation ROS S-glutathionylation. ablation elevated lipid content cells....
Abstract Persistent coronary endothelial dysfunction predicts future adverse events; however, performing multiple invasive function tests is difficult in actual clinical practice. This study examined the association between carotid plaque progression and persistent using serial assessments of vasomotor response to acetylcholine (ACh) infarct-related artery (IRA) among patients with ST-elevation acute myocardial infarction (STEMI). included 169 consecutive a first STEMI due left anterior...
Although plasminogen activator inhibitor-1 (PAI-1) is abundantly expressed in infarcted myocardium, the pathogenic role of myocardial PAI-1 remains unknown. This study examined whether lesion contributes to coronary endothelial dysfunction and left ventricular (LV) patients with acute infarction (AMI).Plasma levels activity tissue-plasminogen (tPA) antigen were measured 2 weeks 6 months after MI by ELISA plasma obtained from aortic root (AO) anterior interventricular vein (AIV) 28 a first...
The role of stromal cell-derived factor-1α (SDF-1α) expressed in infarcted myocardium is unknown humans. We examined whether SDF-1α produced an myocardial lesion may play a left ventricle (LV) remodeling and dysfunction patients with acute infarction (AMI). measured levels plasma obtained from aortic root (AO) anterior interventricular vein (AIV) the early phase (2 wk after MI) chronic (6 mo 80 MI. An increment level AO to AIV, reflecting release myocardium, was more frequent MI [n = 52...
To examine whether improvement in flow-mediated endothelium-dependent dilatation (FMD) of the brachial artery and brachial-ankle pulse wave velocity (baPWV) has an additive effect on achieving optimal goals traditional risk factors to reduce cardiovascular patients with coronary disease (CAD).
Inducible nitric oxide synthase (iNOS) induced by inflammatory cytokines and iNOS activity in bronchial epithelial cells is a major determinant of fractional exhaled (FeNO) levels. The aim this study was to investigate the association promoter gene polymorphisms FeNO levels Japanese asthmatics before introduction asthma treatment. Asthmatics were recruited from Fukushima Medical University Hospital. Genotyping pentanucleotide repeat (CCTTT)n seven previously detected single nucleotide (SNPs)...
Increased level of hydrogen sulphide (H2 S) in sputum is reported to be a new biomarker neutrophilic airway inflammation chronic disorders. However, the relationship between H2 S and disease activity remains unclear.We investigated whether levels could vary during different conditions asthma.H2 serum were measured using sulphide-sensitive electrode 47 stable asthmatic subjects (S-BA), 21 uncontrolled (UC-BA), 26 with acute exacerbation (AE-BA) 15 healthy subjects. Of these, stable, as well...
Ultrasound assessment of either intima-media thickness (IMT) or plaque echolucency the carotid artery provides prognostic information on coronary events. This study examined hypothesis that IMT and may remain useful for prediction events in patients with disease (CAD) after achievement LDL-C goals statin therapy.Ultrasound maximum (maxIMT) integrated backscatter (IBS) analysis was performed 357 chronic CAD <100mg/dl therapy. All were prospectively followed up until occurrence one following...
Non-ST-elevation myocardial infarction (NSTEMI) carries a poor prognosis, and accurately prognostication has significant clinical importance. In this study, we analyzed the predictive value of CHADS