A5101607694- Rheumatoid Arthritis Research and Therapies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Synthesis and Biological Evaluation
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Neurological Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Cell Adhesion Molecules Research
- Lanthanide and Transition Metal Complexes
- Immune Response and Inflammation
- Inorganic and Organometallic Chemistry
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coronary Interventions and Diagnostics
- Synthesis and Reactions of Organic Compounds
- Inflammatory Myopathies and Dermatomyositis
- Parathyroid Disorders and Treatments
- Vascular anomalies and interventions
- Bone Metabolism and Diseases
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- Peripheral Artery Disease Management
- Synthesis of heterocyclic compounds
Peoples' Friendship University of Russia
2004-2022
Chuvash State University
2020-2021
University of Illinois Chicago
2009-2020
Russian Medical Academy of Continuous Professional Education
2019
Illinois College
2016
Sechenov University
2016
University of Chicago
2007
National Academy of Sciences of Ukraine
1995
L.V. Pisarzhevskii Institute of Physical Chemistry
1993
Objective Levels of Toll‐like receptor 7 (TLR‐7) are elevated in rheumatoid arthritis (RA), but the impact on RA is unknown because endogenous ligand for TLR‐7 has not been identified. The aim this study was to identify a and determine its role pathogenesis RA. Methods presence an ligand, microRNA let‐7b (miR‐let‐7b), examined by real‐time polymerase chain reaction (PCR) analysis. Using knockdown cells, TLR‐7–knockout mice, or antagonist, specificity miR‐let‐7b as potential tested. mechanism...
To investigate the relationship between Krebs von den Lungen 6 (KL-6) and CCL18 levels severity progression of systemic sclerosis (SSc)-related interstitial lung disease (ILD).Patients enrolled in Scleroderma Lung Study II (cyclophosphamide [CYC] versus mycophenolate mofetil [MMF]) were included. Baseline 12-month plasma samples analyzed by enzyme-linked immunosorbent assay to assess KL-6 levels. The forced vital capacity (FVC) diffusing for carbon monoxide (DLco) measured every 3 months....
The innate immune system plays an important role in rheumatoid arthritis (RA) pathogenesis. Previous studies support the of TLR2 and 4 RA experimental models; however, regulation pathogenic effect TLR5 is undefined RA. In this study, we show that elevated osteoarthritis ST lining sublining macrophages endothelial cells compared with normal individuals. Furthermore, expression synovial fluid peripheral blood monocytes vitro-differentiated macrophages. We also found on modulator TNF-α these...
Although the role of IL-7 and IL-7R has been implicated in pathogenesis rheumatoid arthritis (RA), majority studies have focused on effect IL-7/IL-7R T cell development function. Our novel data, however, document that patients with RA greater disease activity higher levels IL-7, IL-7R, TNF-α monocytes, suggesting a feedback regulation between cascades myeloid cells is linked to chronic progression. Investigations into involved mechanism showed potent chemoattractant attracts IL-7R(+)...
<h3>Objective</h3> The aim of the study was to characterise expression, regulation and pathogenic role toll-like receptor 7 (TLR7) TLR8 in rheumatoid arthritis (RA). <h3>Methods</h3> Expression TLR7 demonstrated RA, osteoarthritis (OA) normal (NL) synovial tissues (STs) employing immunohistochemistry. authors next examined mechanism by which ligation mediates proinflammatory response Western blot analysis ELISA. RA monocytes correlated disease activity score (DAS28) tumour necrosis factor α...
Our aim was to examine the impact of TLR5 ligation in rheumatoid arthritis (RA) and experimental pathology. Studies were conducted investigate role on RA mouse myeloid cell chemotaxis or osteoclast formation, addition, uncover significance TNF-α function TLR5-mediated pathogenesis. Next, vivo mechanism action determined collagen-induced (CIA) local joint models. Last, evaluate importance RA, we used anti-TLR5 Ab therapy CIA mice. We show that agonist, flagellin, can promote monocyte...
Background The clinical utility of testing for antiphospholipid antibodies (aPL) IgA isotype remains controversial. Methodology/Principal Findings To address this issue, we reasoned that if aPL contribute to the manifestations syndrome, then an association with thromboembolic events should manifest in patients whose only is isotype. We performed a retrospective chart review 56 (31 systemic lupus erythematosus [SLE] and 25 without SLE) positive was anti-β2-glycoprotein I (isolated anti-β2GPI)...
<h3>Objective</h3> This study was conducted to determine the expression pattern, regulation and function of CCL28 CCR10 in rheumatoid arthritis (RA) pathogenesis. <h3>Methods</h3> Expression assessed RA compared with other synovial tissues (STs) or fluids (SFs) by histology ELISA. The factors modulating were identified myeloid endothelial cells ELISA, FACS Western blotting. mechanism which ligation promotes angiogenesis examined control CCR10-knockdown cell chemotaxis capillary formation....
To examine the impact of Toll-like receptor 5 (TLR-5) on endothelial cell function in rheumatoid arthritis (RA) and vascularization collagen-induced (CIA).Endothelial migration tube formation assays were used to demonstrate direct role TLR-5 ligation angiogenesis. Mice with CIA treated agonist flagellin document effect RA pathology. Vascularization was determined by immunohistochemical analysis determination cytokine levels ankle joints. Spleen Th17 cells joint interleukin-17 (IL-17)...
Abstract Thirty percent of psoriasis patients develop psoriatic arthritis (PsA), nevertheless the mechanism remains unknown. Endogenous GU‐rich miRNAs activate endosomal TLR7 that plays a critical role in autoimmune diseases. We found endogenous ligands, miR‐29 and miR‐Let7b, were markedly increased PsA compared to osteoarthritis (OA) synovial fluid (SF)s. showed intradermal (i.d.) miR‐Let7b injection promoted skin inflammation, which was characterized by amplified Th1 cells, CD68 + M1...
Studies were performed to uncover the significance of obesity in rheumatoid arthritis (RA) and preclinical models.Preclinical models used examine impact on disease onset remission. Conditioned media from RA adipose tissues investigate mechanism contributing joint neutrophil influx M1 macrophage differentiation observed early remission phases arthritis.We report that mice fed with high fat diet (HFD) have an earlier collagen-induced (CIA) compared regular diet. However, differences CIA...
Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder characterized by the development of large indurated plaques on skin, primarily in patients with end‐stage renal disease (ESRD). Skin biopsy reveals an increased frequency CD34 + and Factor XIIa+ cells. Microscopic calcification has been reported skin biopsies rare cases NSF. The etiology significance this not clear. We present two typical NSF, for which marked stromal vascular was identified biopsy. In both cases, within NSF lesions...
Objective . To investigate the role of whole blood viscosity in digital ulcer (DU) development patients with diffuse and limited Systemic sclerosis. Methods A convenience sample sclerosis (SSc) was selected from adult Rheumatology clinic at University Chicago. The study group consisted SSc (with ulcers present, a history ulcers, no ulcers); control matched healthy staff. WBV measured using scanning capillary viscometer different shear rates (1–1000 1/s). Results Whole as by increased...
The flow of heated dense plasma obtained in the discharge region an electrothermal launcher can be used for acceleration powder material particles. After being accelerated and flow, particles impact substrates produce coatings with strong adhesion low porosity. An system which includes a unit, initiation injector was constructed. A theoretical model based on one-dimensional nonstationary hydrodynamic analysis flows developed. Relationships among major output parameters (the density,...
Formation of new blood vessels is essential for vascular repair and remodeling, it known that biomechanical properties extracellular matrix play a major role in this process. Our earlier studies have also shown exposing endothelial cells to oxidized modification low‐density lipoproteins (oxLDL) increases stiffness facilitates their ability form cellular networks, suggesting angiogenic potential. The goal study, therefore, was test the interrelationship between oxLDL regulation angiogenesis....
The study was aimed at demonstrating efficacy and feasibility of intravascular ultrasound during internal carotid artery stenting for assessment atheromatous plaque protrusion through a stent.Over the period from October to December 2018, specialists our Centre performed total 90 procedures in 83 patients (of these, 7 underwent bilateral staged both arteries) using order assess intraoperative an atherosclerotic implanted stent. patients' age varied 42 87 (mean 68.6±6.9) years. Symptomatic...