Darryl P. Leong
A5069359085- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Prostate Cancer Treatment and Research
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Cancer, Lipids, and Metabolism
- Cardiomyopathy and Myosin Studies
- Frailty in Older Adults
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Health and Mental Health
- Health disparities and outcomes
- Heart Failure Treatment and Management
Population Health Research Institute
2016-2025
McMaster University
2016-2025
Hamilton Health Sciences
2016-2025
Impact
2018-2024
Flinders University
2009-2024
The University of Adelaide
2008-2024
East Kent Hospitals University NHS Foundation Trust
2024
Tolmar (United States)
2024
City of Hope
2024
Hamilton General Hospital
2014-2023
We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than for secondary cardiovascular prevention.In this double-blind trial, we randomly assigned 27,395 participants stable atherosclerotic vascular disease to receive (2.5 mg twice daily) plus (100 once daily), (5 daily). The primary outcome was a composite of death, stroke, myocardial infarction. study stopped superiority the rivaroxaban-plus-aspirin group after mean follow-up 23 months.The occurred...
IMPORTANCEObesity is a risk factor for atrial fibrillation.Whether weight reduction and cardiometabolic management can reduce the burden of fibrillation not known.OBJECTIVE To determine effect factors on cardiac structure.DESIGN, SETTING, AND PATIENTS Single-center, partially blinded, randomized controlled study conducted between June 2010 December 2011 in Adelaide, Australia, among overweight obese ambulatory patients (N = 150) with symptomatic fibrillation.Patients underwent median 15...
Abstract Background The measurement of handgrip strength (HGS) has prognostic value with respect to all‐cause mortality, cardiovascular mortality and disease, is an important part the evaluation frailty. Published reference ranges for HGS are mostly derived from Caucasian populations in high‐income countries. There a paucity information on normative values non‐Caucasian low‐ or middle‐income objective this study was develop healthy adults broad range ethnicities socioeconomically diverse...
Long-term continuous electrocardiographic monitoring shows a substantial prevalence of asymptomatic, subclinical atrial fibrillation (SCAF) in patients with pacemakers and cryptogenic stroke. Whether SCAF is also common other without these conditions unknown.We implanted subcutaneous monitors (St. Jude CONFIRM-AF) ≥65 years age attending cardiovascular or neurology outpatient clinics if they had no history but any the following: CHA2DS2-VASc score ≥2, sleep apnea, body mass index >30 kg/m2....
BackgroundHypertension is considered the most important risk factor for cardiovascular diseases, but its control poor worldwide. We aimed to assess availability and affordability of blood pressure-lowering medicines, association with use these medicines pressure in countries at varying levels economic development.MethodsWe analysed availability, costs, data recorded from 626 communities 20 participating Prospective Urban Rural Epidemiological (PURE) study. Medicines were available if they...
The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, respiratory hospitalisations are unclear, how these might vary across populations is unknown.In this international, community-based cohort study, we prospectively enrolled adults aged 35-70 years who had no intention moving residences for 4 from rural urban communities 17 countries. A portable spirometer was used to assess FEV1. FEV1 values were...
The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men prostate cancer and known atherosclerotic disease remains controversial.In this international, multicenter, prospective, randomized, open-label trial, concomitant were randomly assigned 1:1 to receive the antagonist degarelix or agonist leuprolide for 12 months. primary outcome was time first adjudicated major adverse event (composite death, myocardial infarction,...