A5000695652- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Renal and Vascular Pathologies
- Abdominal Trauma and Injuries
- Surgical Simulation and Training
- Organ Donation and Transplantation
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Anatomy and Medical Technology
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Urinary Bladder and Prostate Research
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Urology and Nephrology Studies
- Medical Image Segmentation Techniques
- Cancer, Lipids, and Metabolism
- Kidney Stones and Urolithiasis Treatments
- 3D Printing in Biomedical Research
- AI in cancer detection
- Renal Diseases and Glomerulopathies
Centre Hospitalier Universitaire de Grenoble
2015-2024
Université Grenoble Alpes
2014-2024
Centre National de la Recherche Scientifique
1996-2023
VetAgro Sup
2023
Institut polytechnique de Grenoble
2019-2023
Translational Innovation in Medicine and Complexity
2013-2022
Metabolism and Renal Physiology
1998-2018
Inserm
2016-2018
Université Joseph Fourier
1996-2018
Service de la Santé Publique
2006-2012
The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men prostate cancer and known atherosclerotic disease remains controversial.In this international, multicenter, prospective, randomized, open-label trial, concomitant were randomly assigned 1:1 to receive the antagonist degarelix or agonist leuprolide for 12 months. primary outcome was time first adjudicated major adverse event (composite death, myocardial infarction,...
Recent guidelines favor transperineal (TP) prostate biopsies over the transrectal (TR) approach due to a reduced sepsis risk. Yet, evidence from controlled trial comparing both approaches within MRI-targeted pathway for significant cancer (PCa) detection is lacking.
The management of major renal trauma has shifted in the last decade favor a nonoperative approach. Our level 1 center promotes this approach with objective function preservation. However, certain situations still require surgery. In study we analyze predictors surgery and long-term outcomes after conservative management.From January 2004 to March 2015 prospectively collected data from all patients admitted our institution for high grade blunt (grades IV V). Nonoperative was considered...
Prostate brachytherapy involves implanting radioactive seeds for instance) permanently in the gland treatment of localized prostate cancers, e.g., cT1c‐T2a N0 M0 with good prognostic factors. Treatment planning and seed are most often based on intensive use transrectal ultrasound (TRUS) imaging. This is not easy because visualization difficult this imaging modality particularly as regards apex from an intra‐ interobserver variability standpoint. Radioactive implanted inside open...
What's known on the subject? and What does study add? Using a standardized classification for renal tumours is major step towards an objective comparison of indications expected outcomes partial nephrectomy ( PN ). Several scores have been described, including RENAL score RNS ), to evaluate anatomical features tumour predict surgical challenges with particular regard . Previous studies show discrepancies effectiveness using postoperative outcomes. Although we showed that conversion radical...
Clear cell renal carcinoma (ccRCC) is the third type of urologic cancer. At time diagnosis, 30% cases are metastatic with no effect chemotherapy or radiotherapy. Current targeted therapies lead to a high rate relapse and resistance after short-term response. Thus, major hurdle in development use new treatments for ccRCC lack good pre-clinical models that can accurately predict efficacy drugs allow stratification patients into correct treatment regime. Here, we describe different 3D cultures...
Abstract Outcome of patients with renal cell carcinoma nodal metastases (NM) is substantially worse than that localized disease. This justifies more thorough staging and possibly aggressive treatment in those at risk or established NM. We developed externally validated a nomogram capable highly accurately predicting NM without radiographic evidence distant metastases. Age, symptom classification, tumour size the pathological stage were available for 4,658 individuals. The data 2,522 (54.1%)...
To predict the outcomes of a non-operative approach to managing urinary extravasation after blunt renal trauma.A prospective observational study was conducted between January 2004 and October 2011. First-line management proposed for 99 patients presenting with grade IV injury according revised American Association Surgery Trauma (AAST) classification. Among them, 72 presented extravasation. Management were recorded compared those who did not present leakage. Relative postoperative function...
Renal cell carcinoma (RCC) exhibits significant heterogeneity, making it challenging to predict tumor aggressiveness and therapeutic response. To improve prognostic accuracy develop tailored treatment strategies, is crucial mimic both cancer cells their microenvironment in vitro. Using a combination of vitro vivo models, we investigated the invasive properties three RCC lines RCC10, RCC7 786-O that displayed distinct signaling profiles, combining EMT characteristics upregulation key...