A5013048501- Acute Myocardial Infarction Research
- Migraine and Headache Studies
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Trigeminal Neuralgia and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Psychosomatic Disorders and Their Treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Clinical practice guidelines implementation
- Quality and Safety in Healthcare
- Obesity, Physical Activity, Diet
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Statistical Methods in Clinical Trials
- Advanced X-ray and CT Imaging
- Cardiovascular Syncope and Autonomic Disorders
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Risk Factors
- Radiation Dose and Imaging
Sunovion (United States)
2022-2023
CURE International UK
2022
Population Health Research Institute
2013-2020
Hamilton Health Sciences
2013-2020
McMaster University
2013-2020
University of Limpopo
2018
UCSI University
2018
Spanish Society of Hematology and Hemotherapy
2015
University of Toronto
2007-2012
Canadian Heart Research Centre
2006-2012
Patients with a myocardial infarction ST-segment elevation who present to hospitals that do not have the capability of performing percutaneous coronary intervention (PCI) often cannot undergo timely primary PCI and therefore receive fibrinolysis. The role optimal timing routine after fibrinolysis been established.We randomly assigned 1059 high-risk patients had were receiving fibrinolytic therapy at centers did either standard treatment (including rescue PCI, if required, or delayed...
BackgroundHypertension is considered the most important risk factor for cardiovascular diseases, but its control poor worldwide. We aimed to assess availability and affordability of blood pressure-lowering medicines, association with use these medicines pressure in countries at varying levels economic development.MethodsWe analysed availability, costs, data recorded from 626 communities 20 participating Prospective Urban Rural Epidemiological (PURE) study. Medicines were available if they...
Our objectives were (i) to compare the discriminatory performance of Thrombolysis in Myocardial Infarction risk score (TIMI RS), Platelet glycoprotein IIb/IIIa Unstable angina: Receptor Suppression Using Integrilin Therapy (PURSUIT and Global Registry Acute Cardiac Events (GRACE RS) for in-hospital 1 year mortality across broad spectrum non-ST-elevation acute coronary syndromes (ACS) (ii) determine their incremental prognostic utility beyond overall assessment by physicians.We calculated...
Abstract Objectives/Background Until recently, guidelines for migraine prevention recommended avoiding known headache triggers. Adhering to healthy lifestyle behaviors is also recommended. In a recent cohort study many triggers were found decrease the probability of attacks in some individuals. The extent which people with adhere recommendations unknown. We set out determine if trigger factors and daily adherence are associated decreased Methods This was an observational longitudinal...
The importance of early and aggressive initiation secondary prevention strategies for patients with both coronary artery disease (CAD) cerebrovascular (CVD) is emphasized by multiple guidelines. However, limited information available on cardiovascular protection stroke in an outpatient setting from community-based populations. We sought to evaluate compare differences treatment patterns the attainment current guideline-recommended targets unselected high-risk ambulatory CAD, CVD, or...
Aims: To prospectively evaluate diabetes management in the primary care setting and explore factors related to guideline-recommended triple target achievement [blood pressure (BP) ≤ 130/80 mmHg, A1C 7% low-density lipoprotein (LDL)-cholesterol < 2.5 mmol/l]. Methods: Baseline, 6 12 month data on clinical laboratory parameters were measured 3002 patients with type 2 enrolled as part of a prospective quality enhancement research initiative Canada. A generalised estimating equation model was...
Abstract Objective To assess whether alcohol intake is associated with the onset of migraine attacks up to 2 days after consumption in individuals episodic (EM). Background Although has long been suspected be a common trigger, studies have inconclusive proving this association. Methods This was an observational prospective cohort study among who registered use digital health platform for headache. Eligible were aged ≥18 years EM consumed and had tracked their headache symptoms ≥90 days....
We sought to determine the effectiveness of early routine percutaneous coronary intervention (PCI) post-fibrinolysis for ST-elevation myocardial infarction (STEMI) in relation baseline risk status.In this post hoc subgroup analysis Trial Routine Angioplasty and Stenting after Fibrinolysis Enhance Reperfusion Acute Myocardial Infarction (TRANSFER-AMI), we stratified 1059 STEMI patients receiving tenecteplase into low-intermediate [Global Registry Coronary Events (GRACE) score<155; n=889] vs....
To describe patterns of perceived stress across stages the migraine cycle, within and between individuals episodes as defined for this study.Individuals with aged ≥18 years, who were registered to use digital health platform N1-HeadacheTM , completed 90 days daily data entry regarding migraine, headache symptoms, lifestyle factors eligible inclusion. Perceived was rated once a day at participant's chosen time single question, "How stressed have you felt today?" response options graded on...
Abstract Objective We aimed to describe patterns of peak attack severity from day‐to‐day, and in relation same‐day perceived stress, individuals with chronic migraine (CM). Background Although changes stress are often believed trigger attacks, little is known about the relationship between severity, role day‐to‐day experience CM, as opposed those less frequent attacks. Methods This was an observational prospective longitudinal cohort study among adults CM. Daily data headache, symptoms,...
Covert brain infarcts are associated with cognitive decline. It is not known whether therapies that prevent symptomatic stroke covert infarcts. COMPASS compared rivaroxaban and without aspirin for the prevention of stroke, myocardial infarction, vascular death in participants stable disease was terminated early because benefits 2.5 mg twice daily plus over aspirin. We obtained serial magnetic resonance imagings tests a consenting subgroup patients to examine treatment effects on infarcts,...
Background Covert vascular disease of the brain manifests as infarcts, white matter hyperintensities, and microbleeds on MRI. Their cumulative effect is often a decline in cognition, motor impairment, psychiatric disorders. Preventive therapies for covert ischemia have not been established but represent huge unmet clinical need. Aims The MRI substudy examines effects antithrombotic regimens COMPASS incident infarcts (the primary outcome), cognitive functional status sample consenting...
To describe the association between day-to-day peak pain severity and clinical factors in individuals with chronic migraine (CM).
OBJECTIVE To identify factors in patients with type 2 diabetes and A1C &gt;7.0% associated attainment of ≤7.0%. RESEARCH DESIGN AND METHODS We used a prospective registry 5,280 Canadian primary care settings enrolled 12-month glycemic pharmacotherapy optimization strategy based on national guidelines. RESULTS At close out, median was 7.1% (vs. 7.8% at baseline) 48% subjects achieving ≤7.0% (P &lt; 0.0001). Older Asian or black origin, those longer duration, lower baseline A1C, BMI,...