Germán Málaga
A5017390449- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Health and Lifestyle Studies
- Blood Pressure and Hypertension Studies
- Health and Medical Education
- Public Health and Environmental Issues
- Global Public Health Policies and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Chronic Disease Management Strategies
- Meta-analysis and systematic reviews
- Health and Medical Research Impacts
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Diabetes Management and Research
- Cardiovascular Health and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Stroke Rehabilitation and Recovery
- Acute Myocardial Infarction Research
- Stress and Burnout Research
- Medication Adherence and Compliance
- High Altitude and Hypoxia
Universidad Peruana Cayetano Heredia
2016-2025
Hospital Nacional Cayetano Heredia
2014-2024
Mayo Clinic in Florida
2015-2022
Centro Peruano de Estudios Sociales
2022
Hospital Marina Baixa
2020
Cleveland Clinic
2020
Chinese University of Hong Kong
2018
Hospital de Clínicas de Porto Alegre
2018
University College London
2018
Christian Medical College & Hospital
2018
Of the 200 million adults worldwide who undergo noncardiac surgery each year, more than 1 will die within 30 days.To determine relationship between peak fourth-generation troponin T (TnT) measurement in first 3 days after and 30-day mortality.A prospective, international cohort study that enrolled patients from August 6, 2007, to January 11, 2011. Eligible were aged 45 years older required at least an overnight hospital admission having surgery.Patients' TnT levels measured 6 12 hours on 1,...
Abstract Background: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial due to ischemia that occurs during or within 30 days surgery. The study’s four objectives were determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS. Methods: In this international, prospective cohort study 15,065 patients aged 45 yr older who underwent in-patient surgery, troponin T measured first 3 postoperative days. Patients with a...
There is substantial variability in the perioperative administration of aspirin patients undergoing noncardiac surgery, both among who are already on an regimen and those not.Using a 2-by-2 factorial trial design, we randomly assigned 10,010 were preparing to undergo surgery at risk for vascular complications receive or placebo clonidine placebo. The results reported here. stratified according whether they had not been taking before study (initiation stratum, with 5628 patients)...
Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality myocardial injury after noncardiac surgery (MINS).To determine association hsTnT potential diagnostic criteria for MINS (ie, due to ischemia associated with mortality).Prospective cohort study of patients aged 45 years or older who underwent inpatient had a postoperative measurement. Starting in October 2008, participants were recruited at 23 centers 13...
Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central outflow, may prevent perioperative myocardial infarction death without inducing hemodynamic instability.We performed a blinded, randomized trial with 2-by-2 factorial design to allow separate evaluation low-dose clonidine versus placebo aspirin in patients with, or at risk for, atherosclerotic disease who were undergoing A total 10,010 135 centers 23...
Among adults undergoing contemporary noncardiac surgery, little is known about the frequency and timing of death associations between perioperative complications mortality. We aimed to establish its association with complications.We conducted a prospective cohort study patients aged 45 years older who underwent inpatient surgery at 28 centres in 14 countries. monitored for until 30 days after determined relation these 30-day mortality using Cox proportional hazards model.We included 40 004...
Introduction Peru is among the top ten countries with highest number of coronavirus disease 2019 (COVID-19) cases worldwide. The aim study was to describe clinical features hospitalized adult patients COVID-19 and determine prognostic factors associated in-hospital mortality. Methods We conducted a retrospective cohort admitted Hospital Cayetano Heredia; tertiary care hospital in Lima, Peru. primary outcome Multivariate Cox proportional hazards regression used identify independently Results...
Acute kidney injury, a common complication of surgery, is associated with poor outcomes and high health care costs. Some studies suggest aspirin or clonidine administered during the perioperative period reduces risk acute injury; however, these effects are uncertain each intervention has potential for harm.To determine whether compared placebo, alters injury.A 2 × factorial randomized, blinded, clinical trial 6905 patients undergoing noncardiac surgery from 88 centers in 22 countries...
Objectives: The objective is to describe hypertension (HTN) prevalence, awareness, treatment and control in urban rural communities Latin America inform public policy-makers. Methods: Cross-sectional analysis from (n = 111) 93) including 33 276 participants six American countries (Argentina, Brazil, Chile, Colombia, Peru Uruguay) were included. HTN was defined as self-reported on blood pressure (BP) medication or average BP over 140/90 mmHg, awareness HTN, controlled those with under mmHg....
Symptoms of sleep disturbance are common and may represent important modifiable risk factors stroke. We evaluated the association between a spectrum symptoms acute stroke in an international setting.The INTERSTROKE study is case-control patients presenting with first controls matched by age (±5 years) sex. Sleep previous month were assessed through questionnaire. Conditional logistic regression estimated stroke, expressed as odds ratios (ORs) 95% CIs. The primary model adjusted for age,...
The bleeding safety of ticagrelor in patients with ST-elevation myocardial infarction treated fibrinolytic therapy remains uncertain.