A5069536365- Ion channel regulation and function
- Muscle activation and electromyography studies
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Respiratory viral infections research
- Cardiac Ischemia and Reperfusion
- Neurotransmitter Receptor Influence on Behavior
- Cardiovascular and exercise physiology
- Iron Metabolism and Disorders
- Neurobiology and Insect Physiology Research
- Pharmacological Effects and Assays
- Lipid Membrane Structure and Behavior
- Apelin-related biomedical research
- COVID-19 and Mental Health
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Cardiomyopathy and Myosin Studies
- Biochemical effects in animals
- Force Microscopy Techniques and Applications
- Nuclear Receptors and Signaling
- Nutrition and Health in Aging
Universidad de Colima
2016-2025
University of Washington Bothell
2017-2020
University of California, Irvine
2020
Universidad de Guadalajara
2010-2020
Mexican Social Security Institute
2020
University of Limpopo
2018
UCSI University
2018
Population Health Research Institute
2018
Hamilton Health Sciences
2018
McMaster University
2018
Forskolin is a diterpene derived from the plant Coleus forskohlii.Forskolin activates adenylate cyclase, which increases intracellular cAMP levels.The antioxidant and antiinflammatory action of forskolin due to inhibition macrophage activation with subsequent reduction in thromboxane B2 superoxide levels.These characteristics have made an effective medication for heart disease, hypertension, diabetes, asthma.Here, we evaluated effects chronic administration on blood glucose oxidative stress...
To identify factors predicting severe coronavirus disease 2019 (COVID-19) in adolescent and adult patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection.A retrospective cohort study took place, data from 740 subjects, all 32 states of Mexico, were analyzed. The association between the studied (dyspnea requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) 95% confidence intervals (CIs).Severe illness documented 28%...
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
Objective To evaluate the preventive effects of Moringa oleifera on metabolic syndrome (MS) in male Wistar rats. Methods MS was induced by feeding rats a high-fat diet and drinking water containing 10% fructose for 6 weeks. In group, M. orally administered 3 weeks prior to induction MS, while treatment after onset MS. The groups were compared with control group untreated Fasting glucose, oral glucose tolerance, insulin total cholesterol, triglycerides, abdominal circumference, systolic...
Gestational diabetes (GD) has been linked with an increased risk of developing metabolic disorders and behavioral abnormalities in the offspring. Oxidative stress is strongly associated neurodegeneration cognitive disruption. In offspring brains a GD experimental rat model, oxidative prenatal postnatal stages was reported. However, long-term alterations to behavior stress, caused by changes cerebral cortex hippocampus, remain unclear. this study, we evaluated effect on young adult male...
Abstract Background Knowledge regarding factors predicting the SARS-COV-2 reinfection risk is scarce and it has major implications in public health policies. We aimed to identify associated with of symptomatic reinfection. Methods conducted a nationwide retrospective cohort study 99,993 confirmed cases COVID-19 were analyzed. Results The overall (28 or more elapsed days between both episodes onset) was 0.21% (incidence density, 2.5 reinfections per 100,000 person-days) older subjects those...
The present study was carried out to evaluate the effectiveness of nitazoxanide compared with that quinfamide, mebendazole, or both in treatment intestinal protozoa and helminthic infections. A total 677 stool specimens from children aged 2-12 years living 3 communities Colima, México, were analyzed order detect presence cysts, trophozoites, eggs, larvae helminths. 275 infected enlisted a double-blind controlled randomly assigned one 2 groups: Group A, (200 mg for days) B, quinfamide (100 1...
Increasing evidence indicates that chronic exposure to environmental noise may permanently affect the central nervous system. The aim of this study was evaluate long-term effects early on hippocampal cell proliferation adult male rat. Early-weaned Wistar rats were exposed for 15 days a rats' audiogram-fitted adaptation noisy environment. Two months later, injected with cellular marker 5΄bromodeoxiuridine (BrdU), and their brains processed immunohistochemical analysis. Coronal sections...
Objective Our aim was to assess the effects of dietary iron, and compound capsaicin, on hemoglobin as well metabolic indicators including blood glucose, cholesterol, triglycerides, insulin, glucose tolerance. Materials Methods animal model Wistar rat, fed a chow diet, with or without experimentally induced diabetes. Diabetic males were control, low, high-iron diets, latter, capsaicin. Healthy rats identical but capsaicin supplement. We then measured parameters listed above, using Student...
In the present study, we investigated composition and antioxidant activity of hexanic extract Eryngium carlinae inflorescences by employing in vitro assays to measure capacity 2,2-diphenyl-1-picrylhydrazyl scavenging activity. We also applied Saccharomyces cerevisiae, under hydrogen peroxide-induced stress. Finally, tested male Wistar rats with without streptozotocin-induced diabetes. The compounds were analyzed gas-chromatography-mass spectrometry, which revealed mainly terpenes...
This work presents a pH sensor platform combining the high performance of iridium oxide (IrOx) fabricated by cyclic voltammetry with inductively-coupled wireless (ICW) transmission. Data included flexible potentiometric sensors having IrOx as sensing electrode and cured Ag/AgCl paste pseudo-reference electrode; further investigations concerning tailoring via fabrication processes are shown. The show best probe surface area 1 × mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
Abstract Recent studies confirm that astrocytes and neurons are associated with the synaptic transmission, particularly regulation of glutamate (Glu) levels. Therefore, they have capacity to modulate Glu released from into extracellular space. It has also been demonstrated an intense astrocytic microglia response physical or chemical lesions central nervous system. However, persistence glial cells in adult brain had not previously reported, after excitotoxic damage caused by neonatal dosage...
Pregnant women have been classified as at risk for COVID-19 due to previous experience with influenza and other coronaviruses. The objective of this study was identify factors the complications death in childbearing age pregnant suspected COVID-19.This retrospective cohort conducted from beginning epidemic Mexico until May 25, 2020. All (13-49 years) open national database Ministry Health were considered eligibility. SARS-COV-2 infection confirmed or ruled out by RT-qPCR. We performed a...
Ultraviolet radiation absorption is responsible for the production of free radicals in damaged cells. This side effect may be neutralized using antioxidant substances. It has been reported that ascorbic acid and d-alpha-tocopherol scavenge reactive oxygen species. In a single-blind controlled clinical trial we studied 45 healthy volunteers divided into three groups. Group 1 received 1,200 I.U. daily; 2 g daily 3 plus daily. Treatment was sustained one week. Before after treatment, minimal...
Abstract Recently, numerous guide chambers for the treatment of injured nerves made up different biomaterials have been designed, capable hosting living cells or carrying neurotrophic neuroactive substances to be directly released tissue. In this study, chitosan prostheses containing neurosteroids (progesterone and pregnenolone) were used bridging a 10‐mm gap in rabbit facial nerve. Gas chromatography was quantify neurosteroid content prior after subcutaneous implantation at periods 60 days....
Three experiments were carried out to determine the optimum selenium-vitamin E injection level maintain acceptable blood selenium (Se) status of does and kids, as well relation that mortality rates in kids. In experiment 1, 238 goats assigned one three groups during mating period: A1-control, A2- 0.06mgSe+0.8IU vitE/kgBW A3-0.125mgSe+1.7IU vitE/kgBW. No differences (P>.05) for fertility prolificacy observed among groups. Blood Se concentration did not differ Se-vit control group before...
To determine the efficacy of forskolin in preventing asthma attacks, we performed a single-blinded clinical study children and adult out-patients at public hospital Mexico. Forty patients either sex with mild persistent or moderate were assigned randomly to 6 months treatment 10 mg/day orally (capsules) two inhalations sodium cromoglycate every 8 h, i.e. three times day. The number who had attacks during period was significantly lower among those receiving (8/20, 40%) than (17/20, 85%)....