A5005145062- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Bone Metabolism and Diseases
- Multiple Sclerosis Research Studies
- Nuclear Receptors and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Spondyloarthritis Studies and Treatments
- Macrophage Migration Inhibitory Factor
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Telomeres, Telomerase, and Senescence
- Apelin-related biomedical research
- Nutrition and Health in Aging
- Pharmacogenetics and Drug Metabolism
- Sodium Intake and Health
- Bone health and osteoporosis research
- Bone health and treatments
- Pharmacological Effects and Toxicity Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chemokine receptors and signaling
- Bone and Joint Diseases
- Drug Transport and Resistance Mechanisms
- Health and Medical Education
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
Universidad de Guadalajara
2011-2025
Mexican Social Security Institute
2011-2023
Departamento de Salud
2022
Secretaría de Salud de Jalisco
2018
Universidad de Colima
2016-2017
Universidad de Occidente
2013
Multiple sclerosis (MS) is a chronic, autoimmune pathology that affects the nervous system. It characterized by inflammatory lesions cause axonal damage with neurodegeneration. The signs and symptoms present in this include among others, psychiatric disorders. In MS, depression most frequent disorder, prevalence levels of 40 to 60%; date, unknown. brain-derived neurotrophic factor (BDNF) neurotrophin related neuroplasticity. single-nucleotide polymorphism Val66Met, encoded BDNF gene, has...
Methotrexate (MTX) is the conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) recommended as first-choice for rheumatoid arthritis (RA). However, responses to MTX may be influenced by genetic variants. We aim evaluate association of rs2372536, rs4673990, and rs4673993 variants ATIC gene with therapeutic failure in patients RA. A case–control study was performed. Disease activity measured using disease score based on erythrocyte sedimentation rate (DAS28-ESR). RA were...
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease that affects the nervous system. Peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) are potential biomarkers of neurological disability neural damage. Our objective was to assess LTL mtDNA-CN in relapsing-remitting MS (RRMS). We included 10 healthy controls, 75 patients with RRMS, 50 whom had an Expanded Disability Status Scale (EDSS) from 0 3 (mild moderate disability), 25 EDSS...
Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after transplantation. This transported from cells via P-glycoprotein (ABCB1) and a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, particularly CYP3A4 CYP3A5. Several single-nucleotide polymorphisms (SNPs) have been identified in the genes encoding CYP3A4, CYP3A5, ABCB1, including CYP3A4-392A/G (rs2740574), CYP3A5 6986A/G (rs776746), ABCB1 3435C/T (rs1045642). study aims to evaluate association among...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
Background Gestational diabetes mellitus (GDM) is characterized by insulin resistance. It has been described that tumor necrosis factor α (TNF-α) plays a key role in the pathogenesis of resistance; moreover, increased levels this proinflammatory cytokine have reported women with GDM. Therefore, study was aimed to assess presence associations between -308G/A and -238G/A polymorphisms specific haplotypes TNF-α gene promoter region resistance Mexican Methods This included 51 GDM 44 pregnant...
Objective To identify correlations of the serum leptin, adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) concentrations with clinical characteristics, presence spinal syndesmophytes, body composition in patients ankylosing spondylitis (AS). Methods Forty-eight AS were compared 41 sex- age-matched controls. Assessment included characteristics syndesmophytes. The TNF-α, IL-6 determined. Body was evaluated using dual-energy X-ray absorptiometry. Results Patients controls...
Irisin stimulates osteoblast differentiation increasing bone mass a decreasing in irisin levels might contribute to osteoporotic fractures inflammatory diseases. To date, there is controverted whether are associated with rheumatoid arthritis (RA). Therefore, we evaluate the association of serum Vertebral Fractures (VFs) women RA.A total 148 RA was included study.Clinical characteristics and risk factors VFs evaluated. For measurement mineral density assessment lumbar spine (AP L1-L4) Femoral...
Abstract Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also inflammation. Herein we explore the association between myostatin levels inflammatory parameters rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases 84 with diagnosis of RA were assessed cross-sectional study. Outcomes reflecting activity including Disease Activity Score (DAS28-ESR) impairment functioning...
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 the TNFRSF11B osteoprotegerin ( OPG ) gene has been related to postmenopausal OP although, date, no information described concerning whether this implied abnormalities of bone mineral density (BMD) RA. We evaluated, a case-control study performed Mexican-Mestizo women with RA, SNP associated decrease BMD. RA patients were classified as follows:...
Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and adipokines with lupus nephritis is controversial. Objective assess utility MIF, leptin, adiponectin resistin levels as markers proteinuria renal dysfunction in nephritis. Methods Cross-sectional study including 196 systemic erythematosus (SLE) patients 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Activity Index (SLEDAI). Renal SLE involvement...
Multiple sclerosis (MS) is a chronic and demyelinating disease with an autoimmune origin, which leads to neurodegeneration progressive disability. Approximately 30 50% of patients do not respond optimally disease-modifying therapies (DMTs), therapeutic response may be influenced by genetic factors such as variants. Therefore, our study aimed investigate the association HLA-DRB1*0403 variant DMTs in MS. We included 105 MS diagnosis. No evidence activity based on absence clinical relapse,...
Hypertension is one of the main risk factors related to cardiovascular mortality, being levels blood pressure (BP) a variety personal, anthropometric, biochemical and psychological variables; however, study evaluating association all these in systolic (SBP) diastolic (DBP) sample relatively healthy subjects has not been performed. The aim was determine variables associated with SBP DPB subjects. A total 171 participants were included, which positive negative measured. We observed that men...
Background: Rheumatoid arthritis (RA) in elderly population represents a challenge for physicians terms of therapeutic management. Methotrexate (MTX) is the first-line treatment among conventional synthetic-disease-modifying anti-rheumatic drugs (cs-DMARDs); however, it often associated with adverse events (AEs). Therefore, objective this study was to identify incidence and risk factors MTX discontinuation due AEs patients RA long-term retrospective cohort study. Methods: Clinical sheets...
The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which turn leads to erosion inflammation. Genetic variants the promoter region RANKL gene could lead a higher risk rheumatoid arthritis (RA). Objective: To assess association rs9533155 (-693C>G) rs9533156 (-643T>C) genetic with RA risk. Methods: A case–control study was carried out. total 94 patients (RA group) 134 subjects...
: Some vascular alterations such as peripheral arterial disease (PAD) or stiffness can alter perfusion of the limbs, so we wondered if this is reflected in temperature soles feet diabetic patients who did not have a diagnosis disease. Foot sole was correlated with ankle-brachial index (ABI), carotid-femoral pulse wave velocity (cfPWV), brachial-ankle (baPWV), and age.
Abstract An important goal in the management of systemic lupus erythematosus (SLE) is prediction relapses. This study assesses whether anti-nucleosome antibodies (anti-NCS) increase risk renal relapse inactive SLE. A prospective cohort 115 patients with SLE (M-SLEDAI ≤ 2) were followed for 12 months to assess development (increase M-SLEDAI ≥ 4) and specific flare (renal SLEDAI 4). At baseline, we identified potential factors relapse, including anti-NCS. 18 (16%) anti-NCS positive. 12-month...
Somatization and number of diseases are interrelated variables, whose association with stress-coping strategies, according to sex, has not been investigated. Therefore, the aim this study was investigate such in a sample Mexican general population. The population invited answer an electronic questionnaire via social networks—e-mail, WhatsApp Facebook—by research team. A 1008 adults obtained, which 62.2% were women, whom we detected higher levels negative psychological somatization lower...