A5042732746- Bone Metabolism and Diseases
- Multiple Sclerosis Research Studies
- Bone health and treatments
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Bone health and osteoporosis research
- Medical and Biological Ozone Research
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- vaccines and immunoinformatics approaches
- Moringa oleifera research and applications
- Selenium in Biological Systems
- Psoriasis: Treatment and Pathogenesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
Universidad de Guadalajara
2021-2024
Mexican Social Security Institute
2023
Background: Postmenopausal osteoporosis is a multifactorial disease. Genetic factors play an essential role in contributing to bone mineral density (BMD) variability, which ranges from 60 85%. Alendronate used as the first line of pharmacological treatment for osteoporosis; however, some patients do not respond adequately therapy with alendronate. Aim: The aim this work was investigate influence combinations potential risk alleles (genetic profiles) associated response anti-osteoporotic...
The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which turn leads to erosion inflammation. Genetic variants the promoter region RANKL gene could lead a higher risk rheumatoid arthritis (RA). Objective: To assess association rs9533155 (-693C>G) rs9533156 (-643T>C) genetic with RA risk. Methods: A case–control study was carried out. total 94 patients (RA group) 134 subjects...
Multiple sclerosis (MS) is a chronic and demyelinating disease with an autoimmune origin, which leads to neurodegeneration progressive disability. Approximately 30 50% of patients do not respond optimally disease-modifying therapies (DMTs), therapeutic response may be influenced by genetic factors such as variants. Therefore, our study aimed investigate the association HLA-DRB1*0403 variant DMTs in MS. We included 105 MS diagnosis. No evidence activity based on absence clinical relapse,...
Background. Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease. Low vitamin D levels have been reported to be risk factor for MS, and genetic variances could implicated. The aim of this study was evaluate the association MS with rs10766197 polymorphism CYP2R1 gene rs10877012 CYP27B1 gene. second analyse whether these polymorphisms are associated severity progression MS. Material Methods. In case-control study, we included 116 patients 226 controls, all whom were Mexican...
Multiple sclerosis (MS) is a chronic and demyelinating disease with an autoimmune origin, in which inflammation demyelination lead to neurodegeneration progressive disability. The treatment target slowing down the course mitigating symptoms. Approximately 30 50% of patients do not respond optimally Disease Modifying Therapies (DMTs), therapeutic response may be influenced by genetic factors such as variants. Therefore, our study aimed investigate association HLA DRB1*0403 variant DMTs MS. We...
Background: The Wnt/β catenin pathway promotes bone mineralization stimulating proliferation, differentiation, and survival of osteoblasts; it also inhibits osteoclast differentiation osteocyte activity. Sclerostin (SOST) Dickkopf 1 (DKK1) are inhibitors. Genetic variability in the expression SOST DKK1 might be involved development postmenopausal osteoporosis (OP). Aim: To determine whether rs851056 rs1569198 polymorphisms associated with OP Mexican-Mestizo women. Materials Methods: Two...
Abstract: Green’ methodologies have become the main route for producing selenium nanoparticles (SeNPs), as they do not involve toxic substances that can increase reactivity of synthesized and are practical inexpensive. Extracts from plants, bacteria, fungi, yeasts, ascorbic acid, polysaccharides used to produce these nanoparticles. Plant extracts contain phytochemicals act reducing stabilizing agents, while yeasts synthesize SeNPs metabolites secreted during their development or via...