A5016118013- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Macrophage Migration Inhibitory Factor
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Nuclear Receptors and Signaling
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Regulation of Appetite and Obesity
- Nutrition and Health in Aging
- Bone and Joint Diseases
- Multiple Sclerosis Research Studies
- Folate and B Vitamins Research
- Lymphoma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
Universidad de Guadalajara
2014-2024
Mexican Social Security Institute
2013-2023
Hospital de Especialidades
2013-2022
Departamento de Salud
2022
Universidad de Colima
2020
Hospital General De Zona
2017
Departamento de Epidemiología
2001-2013
Secretaría de Salud de Jalisco
2010
University of Alberta
1997-2000
University of Ottawa
1997
Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic environmental factors. The high prevalence of DM anti-Mi-2 Central America is thought to be associated with the UV index area. prevalences autoantibodies PM/DM were evaluated comparing two cohorts Mexico.Ninety-five Mexican patients (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) studied. characterized immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical...
To describe primary care patterns of referral and diagnoses patients with rheumatic diseases referred to rheumatologists.The medical records all consecutive in 1994 by >300 physicians two rheumatologists at an academic centre were reviewed. The referring physician diagnosis was compared the rheumatologist's diagnosis. Sensitivity, specificity predictive values estimated using rheumatologist as 'gold standard'.University-based rheumatology out-patient clinic.Over half had a soft-tissue...
Objective . To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared 42 RA without involvement (RA only). Characteristics related to assessed all anti-CCP2 quantified. Results Higher found only (medians 77.9 versus...
The aim of this study was to compare the efficacy intravenouscyclophosphamide(IVCYC) versus oral enalapril in mild or moderate pulmonary hypertension (PH) systemic lupus erythematosus (SLE). Thirty-four patients with SLE who had systolic artery pressure (SPAP) > 30mmHg by Doppler echocardiography were randomized receive IVCYC (0.5g/mt 2 body surface area, monthly), (10mg/day) for six months. primary outcome significant decrease SPAP. An additional measure included improvement heart...
The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection in sera plasma samples from patients with pre-eclampsia has been reported inconsistent results. To establish the l levels at level, we studied prospectively a cohort 13 healthy pregnant women.To evaluate changes serum women prospective cohort.Thirteen were followed to IL-17. Each patient was evaluated each trimester. measured by ELISA. statistical analysis done using repeated...
We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated vimentin (anti-MCV) with presence of extra-articular (ExRA) manifestations in 225 patients rheumatoid arthritis (RA). Ninety-five had ExRA 130 no ExRA. There was anti-CCP anti-MCV levels as total group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.40</mml:mn></mml:math>and<mml:math...
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association VAF with proinflammatory cytokines, oxidants, antioxidants, damage DNA in subjects normal weight, overweight, obesity.A cross-sectional that included 21 men 71 women who attended a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) used measure volume. ELISA colorimetric techniques were chemical...
We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women.Three hundred twenty women participated, ©FUNPEC-RP www.funpecrp.com.
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) RA patients.Forty-five anti-CCP positive and 37 negative patients, 62 healthy controls (HC) were studied. All groups assessed for atherogenic index plasma (AIP) cIMT. Anti-CCP, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα) interleukin-6 (IL-6) measured by...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
There is a lack of information about the genotype frequencies IL-6 -174G/C and -572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, aim this study was to evaluate association Mexican mestizo RA.We included 137 patients RA 102 healthy controls. Patients were assessed for clinical characteristics. genotyped using PCR-RFLP analysis. Allele Hardy-Weinberg equilibrium computed. Odds ratios (ORs) computed identify risk associated presence GG comparison GC or CC...
Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor- κ B (RANK), ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG crucial molecular pathway coupling between osteoblasts osteoclasts, since OPG able to inhibit osteoclast differentiation activation. We aim evaluate the association SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) TNFRSF11B (OPG)...