A5071892746- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Macrophage Migration Inhibitory Factor
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Galectins and Cancer Biology
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Folate and B Vitamins Research
Universidad de Guadalajara
2015-2024
Instituto Nacional de Técnica Aeroespacial
2018-2024
Mexican Social Security Institute
2013-2023
Universidad Veracruzana
2023
Departamento de Salud
2013-2022
Instituto Tecnológico de Chetumal
2022
Centro Médico ABC
2022
University of the Valley of Atemajac
2018-2021
Stanford University
2019
United States Bone and Joint Initiative
2019
Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic environmental factors. The high prevalence of DM anti-Mi-2 Central America is thought to be associated with the UV index area. prevalences autoantibodies PM/DM were evaluated comparing two cohorts Mexico.Ninety-five Mexican patients (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) studied. characterized immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical...
Cervical human papillomavirus (HPV+) infection is associated with an increased risk of cervical dysplasia. Although the frequency HPV+ in systemic lupus erythematosus (SLE) has been investigated some races its prevalence Hispanic women still unknown. This cross-sectional study evaluated Mexican SLE ( n = 34) or rheumatoid arthritis (RA) 43) and healthy controls 146). These were interviewed about factors for sexually transmitted infections cytology analysis was performed. viral types...
Objective . To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent interstitial lung disease in rheumatoid arthritis (RA-ILD). Methods In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared 42 RA without involvement (RA only). Characteristics related to assessed all anti-CCP2 quantified. Results Higher found only (medians 77.9 versus...
To examine whether patients who report orofacial pain (OP) and temporomandibular disorders (TMD) have a poorer perception of their oral health-related quality life and, if so, to what extent, analyze the association between health perception, sociodemographic variables reported duration.407 treated at OP TMD units in Healthcare District Cordoba, Spain, diagnosed following standard criteria accepted by scientific community - Research Diagnostic Criteria for Temporomandibular Disorders...
The aim of this study was to compare the efficacy intravenouscyclophosphamide(IVCYC) versus oral enalapril in mild or moderate pulmonary hypertension (PH) systemic lupus erythematosus (SLE). Thirty-four patients with SLE who had systolic artery pressure (SPAP) > 30mmHg by Doppler echocardiography were randomized receive IVCYC (0.5g/mt 2 body surface area, monthly), (10mg/day) for six months. primary outcome significant decrease SPAP. An additional measure included improvement heart...
The function, peripheral blood expression, and physiologic importance of IL-17 is not well established. Detection in sera plasma samples from patients with pre-eclampsia has been reported inconsistent results. To establish the l levels at level, we studied prospectively a cohort 13 healthy pregnant women.To evaluate changes serum women prospective cohort.Thirteen were followed to IL-17. Each patient was evaluated each trimester. measured by ELISA. statistical analysis done using repeated...
We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated vimentin (anti-MCV) with presence of extra-articular (ExRA) manifestations in 225 patients rheumatoid arthritis (RA). Ninety-five had ExRA 130 no ExRA. There was anti-CCP anti-MCV levels as total group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.40</mml:mn></mml:math>and<mml:math...
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women.Three hundred twenty women participated, ©FUNPEC-RP www.funpecrp.com.
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) RA patients.Forty-five anti-CCP positive and 37 negative patients, 62 healthy controls (HC) were studied. All groups assessed for atherogenic index plasma (AIP) cIMT. Anti-CCP, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα) interleukin-6 (IL-6) measured by...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
There is a lack of information about the genotype frequencies IL-6 -174G/C and -572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, aim this study was to evaluate association Mexican mestizo RA.We included 137 patients RA 102 healthy controls. Patients were assessed for clinical characteristics. genotyped using PCR-RFLP analysis. Allele Hardy-Weinberg equilibrium computed. Odds ratios (ORs) computed identify risk associated presence GG comparison GC or CC...
Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor- κ B (RANK), ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG crucial molecular pathway coupling between osteoblasts osteoclasts, since OPG able to inhibit osteoclast differentiation activation. We aim evaluate the association SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) TNFRSF11B (OPG)...
To compare bone turnover marker (BTM) levels and mineral density (BMD) between patients with ankylosing spondylitis (AS) healthy controls (HC) to evaluate, in AS, the association BTM clinical variables, spinal syndesmophytes, BMD using multivariate analysis.Seventy-eight AS were compared 58 HC matched by gender. Spinal syndesmophytes other characteristics assessed. C-terminal telopeptide fragments of type I collagen (CTX), bone-specific alkaline phosphatase (BAP), osteocalcin (OC) serum...