A5015693021- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Bone health and osteoporosis research
- Systemic Lupus Erythematosus Research
- Bone Metabolism and Diseases
- Chronic Lymphocytic Leukemia Research
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- Inflammasome and immune disorders
- Alkaline Phosphatase Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Workplace Health and Well-being
- Nutrition and Health in Aging
- Health and Medical Education
- Corporate Social Responsibility Disclosure
- Muscle Physiology and Disorders
- Bone and Joint Diseases
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Inflammation biomarkers and pathways
- Healthcare Systems and Technology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Orthopedic Infections and Treatments
Mexican Social Security Institute
2012-2021
Departamento de Epidemiología
2016-2021
Departamento de Salud
2016-2021
Universidad de Guadalajara
2012-2021
Universidad de Colima
2017
Universidad Autónoma de Guadalajara
2011
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
To compare bone turnover marker (BTM) levels and mineral density (BMD) between patients with ankylosing spondylitis (AS) healthy controls (HC) to evaluate, in AS, the association BTM clinical variables, spinal syndesmophytes, BMD using multivariate analysis.Seventy-eight AS were compared 58 HC matched by gender. Spinal syndesmophytes other characteristics assessed. C-terminal telopeptide fragments of type I collagen (CTX), bone-specific alkaline phosphatase (BAP), osteocalcin (OC) serum...
Objective To identify correlations of the serum leptin, adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) concentrations with clinical characteristics, presence spinal syndesmophytes, body composition in patients ankylosing spondylitis (AS). Methods Forty-eight AS were compared 41 sex- age-matched controls. Assessment included characteristics syndesmophytes. The TNF-α, IL-6 determined. Body was evaluated using dual-energy X-ray absorptiometry. Results Patients controls...
Abstract Background Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment limited to a low proportion of due cost and equipment technical expertise requirements. The surrogate index triglycerides glucose (TyG index) has been validated non-rheumatic populations, showing adequate sensitivity specificity for IR, although this not yet used connective tissue disorders. aim study was...
Abstract Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also inflammation. Herein we explore the association between myostatin levels inflammatory parameters rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases 84 with diagnosis of RA were assessed cross-sectional study. Outcomes reflecting activity including Disease Activity Score (DAS28-ESR) impairment functioning...
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 the TNFRSF11B osteoprotegerin ( OPG ) gene has been related to postmenopausal OP although, date, no information described concerning whether this implied abnormalities of bone mineral density (BMD) RA. We evaluated, a case-control study performed Mexican-Mestizo women with RA, SNP associated decrease BMD. RA patients were classified as follows:...
Objective . To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients moderate severe rheumatoid arthritis (RA), initiating MTX LEF, genotyped for by PCR-RFLP. Therapeutic was strictly defined: only if achieved remission low disease activity (DAS-28 < 3.2). Results Patients LEF had significant decrement DAS-28 (<mml:math...
Abstract Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability chemerin pro-inflammatory rheumatoid arthritis (RA). identify the association of serum molecules, including adipokines, E-selectin, patients RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) (HAQ-DI). We compared adipokines (chemerin, leptin, adiponectin, resistin,...
Fracture risk assessment tool (FRAX) index was developed for estimating of the 10-year major or hip osteoporotic fracture. To date, there is insufficient information regarding correlation between FRAX and serum bone turnover markers (BTMs), such as soluble ligand receptor activator nuclear factor-κB (sRANKL), osteoprotegerin (OPG), other molecules related with secondary osteoporosis in rheumatoid arthritis (RA). Therefore, this study aimed at assessing levels sRANKL, OPG, sRANKL/OPG ratio,...
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these associated the severe radiographic damage observed some RA patients, particularly those development of joint bone ankylosis (JBA). The objective present study was evaluate association between hands and -174G/C -572G/C IL6 Mexican Mestizo people RA. adults long disease duration (>5 years) were classified into two groups according...
The objective of this study was to investigate the usefulness soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response methotrexate (MTX) rheumatoid arthritis (RA). Patients with active RA, Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire–Disability Index (HAQ-DI), patient’s perception disease severity, morning stiffness...
There is limited information about the factors related with development of long-term permanent work disability (PWD) in rheumatoid arthritis (RA) treated a combination conventional synthetic disease-modifying antirheumatic drugs (cs-DMARDs).The aim this study was to evaluate incidence and associated PWD RA therapy using cs-DMARDs.We assessed multivariate models effect clinical demographic retrospective cohort 180 workers who were cs-DMARDs.Incidence rates 2.2% at 1 year, 7.7% 5 years, 24.9%...
Background: The Wnt/β catenin pathway promotes bone mineralization stimulating proliferation, differentiation, and survival of osteoblasts; it also inhibits osteoclast differentiation osteocyte activity. Sclerostin (SOST) Dickkopf 1 (DKK1) are inhibitors. Genetic variability in the expression SOST DKK1 might be involved development postmenopausal osteoporosis (OP). Aim: To determine whether rs851056 rs1569198 polymorphisms associated with OP Mexican-Mestizo women. Materials Methods: Two...