A5085533870- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Macrophage Migration Inhibitory Factor
- Bone Metabolism and Diseases
- Nuclear Receptors and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Bone health and treatments
- Drug Transport and Resistance Mechanisms
- Apelin-related biomedical research
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Bone health and osteoporosis research
- Peptidase Inhibition and Analysis
- Bone and Joint Diseases
- Diet and metabolism studies
- Lymphoma Diagnosis and Treatment
- Multiple Sclerosis Research Studies
Universidad de Guadalajara
2017-2024
Mexican Social Security Institute
2017-2023
Departamento de Salud
2022
Instituto de Investigaciones en Ciencias de la Salud
2020
Hospital de Especialidades
2017
The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also that its deficiency associated with a prognosis more critical Coronavirus Disease 2019. This study aimed determine baseline serum concentrations and the supplementation asymptomatic or mildly symptomatic 2019 outpatients.
There are controversial results about the role of serum leptin and adiponectin levels as biomarkers severity proteinuria in lupus nephritis.The aim this study was to evaluate relationship between with secondary nephritis (LN).In a cross-sectional study, 103 women systemic erythematosus (SLE) were evaluated for kidney involvement. We compared 30 SLE patients LN, all them proteinuria, versus 73 without renal involvement (no LN). A comprehensive set clinical laboratory variables assessed,...
Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after transplantation. This transported from cells via P-glycoprotein (ABCB1) and a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, particularly CYP3A4 CYP3A5. Several single-nucleotide polymorphisms (SNPs) have been identified in the genes encoding CYP3A4, CYP3A5, ABCB1, including CYP3A4-392A/G (rs2740574), CYP3A5 6986A/G (rs776746), ABCB1 3435C/T (rs1045642). study aims to evaluate association among...
Background Chemerin has a potential role in perpetuating inflammation autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated serum biomarker disease activity RA patients. Methods Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) fat mass. was identified according DAS28-CRP as follows: A)...
Prostate cancer (PCa) is the most prevalent cause of death in male population worldwide. The G Protein-Coupled Estrogen Receptor (GPER) has been gaining relevance development PCa. Hedgehog (Hh) pathway activation associated with aggressiveness, metastasis, and relapse PCa patients. To date, no studies have evaluated crosstalk between GPER Hh along different group grades We conducted an analysis paraffin-embedded tissues derived from patients prognostic grade using immunohistochemistry....
Abstract Background Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment limited to a low proportion of due cost and equipment technical expertise requirements. The surrogate index triglycerides glucose (TyG index) has been validated non-rheumatic populations, showing adequate sensitivity specificity for IR, although this not yet used connective tissue disorders. aim study was...
Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 7) expression sCD74 establish their association with RA clinical activity according DAS28-ESR.101 patients different activities (remission (n = 27), low 16), moderate 35) high 23)) 9 control subjects (CS) were included. Expression was evaluated by flow cytometry levels of soluble CD74 (sCD74)...
Irisin stimulates osteoblast differentiation increasing bone mass a decreasing in irisin levels might contribute to osteoporotic fractures inflammatory diseases. To date, there is controverted whether are associated with rheumatoid arthritis (RA). Therefore, we evaluate the association of serum Vertebral Fractures (VFs) women RA.A total 148 RA was included study.Clinical characteristics and risk factors VFs evaluated. For measurement mineral density assessment lumbar spine (AP L1-L4) Femoral...
Evaluate the type and severity of potential drug-drug interactions identify risk factors involved, in pediatric patients admitted a hospital setting.Transversal retrospective analytical study was carried out with hospitalized from Hospital West Mexico, second third level. The included were ≤18 years old children wards; those at emergency room, neonatal intermediate intensive therapy units not included. Medical prescriptions reviewed taking into consideration anthropometric characteristics,...
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 the TNFRSF11B osteoprotegerin ( OPG ) gene has been related to postmenopausal OP although, date, no information described concerning whether this implied abnormalities of bone mineral density (BMD) RA. We evaluated, a case-control study performed Mexican-Mestizo women with RA, SNP associated decrease BMD. RA patients were classified as follows:...
Abstract Background To date, the association of serum macrophage migration inhibitory factor (MIF) and adipokines with lupus nephritis is controversial. Objective assess utility MIF, leptin, adiponectin resistin levels as markers proteinuria renal dysfunction in nephritis. Methods Cross-sectional study including 196 systemic erythematosus (SLE) patients 52 healthy controls (HCs). Disease activity was assessed by Systemic Lupus Erythematosus Activity Index (SLEDAI). Renal SLE involvement...
STAT4 plays an important role in disease activity SLE patients. particles have the capacity to activate transcription of genes associated with production TH1 and Th17 lymphocytes, a greater predominance on IFN-γ IL-17A. The presence variants has major impact generation autoimmunity. However, there are few studies evaluating these proinflammatory cytokines such as Methods—A case–control study was carried out 206 Mexican mestizo patients residing Western Mexico diagnosis group 80 without...
Multiple sclerosis (MS) is a chronic and demyelinating disease with an autoimmune origin, which leads to neurodegeneration progressive disability. Approximately 30 50% of patients do not respond optimally disease-modifying therapies (DMTs), therapeutic response may be influenced by genetic factors such as variants. Therefore, our study aimed investigate the association HLA-DRB1*0403 variant DMTs in MS. We included 105 MS diagnosis. No evidence activity based on absence clinical relapse,...
The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which turn leads to erosion inflammation. Genetic variants the promoter region RANKL gene could lead a higher risk rheumatoid arthritis (RA). Objective: To assess association rs9533155 (-693C>G) rs9533156 (-643T>C) genetic with RA risk. Methods: A case–control study was carried out. total 94 patients (RA group) 134 subjects...
Abstract An important goal in the management of systemic lupus erythematosus (SLE) is prediction relapses. This study assesses whether anti-nucleosome antibodies (anti-NCS) increase risk renal relapse inactive SLE. A prospective cohort 115 patients with SLE (M-SLEDAI ≤ 2) were followed for 12 months to assess development (increase M-SLEDAI ≥ 4) and specific flare (renal SLEDAI 4). At baseline, we identified potential factors relapse, including anti-NCS. 18 (16%) anti-NCS positive. 12-month...
Background. Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease. Low vitamin D levels have been reported to be risk factor for MS, and genetic variances could implicated. The aim of this study was evaluate the association MS with rs10766197 polymorphism CYP2R1 gene rs10877012 CYP27B1 gene. second analyse whether these polymorphisms are associated severity progression MS. Material Methods. In case-control study, we included 116 patients 226 controls, all whom were Mexican...
Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role NPY autoimmune diseases such as rheumatoid arthritis (RA) not completely understood. Therefore, we evaluate if levels are markers disease activity in RA and there correlation between tumor necrosis factor-alpha (TNF-α), leptin, interleukin 6 (IL-6) levels. Cross-sectional design, including 108 women RA. We assessed by DAS28-ESR (considering active score ≥2.6). Serum anti-CCP2...
Abstract Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability chemerin pro-inflammatory rheumatoid arthritis (RA). identify the association of serum molecules, including adipokines, E-selectin, patients RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) (HAQ-DI). We compared adipokines (chemerin, leptin, adiponectin, resistin,...
Fracture risk assessment tool (FRAX) index was developed for estimating of the 10-year major or hip osteoporotic fracture. To date, there is insufficient information regarding correlation between FRAX and serum bone turnover markers (BTMs), such as soluble ligand receptor activator nuclear factor-κB (sRANKL), osteoprotegerin (OPG), other molecules related with secondary osteoporosis in rheumatoid arthritis (RA). Therefore, this study aimed at assessing levels sRANKL, OPG, sRANKL/OPG ratio,...