A5069429850- Inflammatory Myopathies and Dermatomyositis
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Diseases and Glomerulopathies
- Prenatal Substance Exposure Effects
- Trigeminal Neuralgia and Treatments
- Head and Neck Surgical Oncology
- Chemical synthesis and alkaloids
- Peptidase Inhibition and Analysis
- Botanical Research and Applications
- Facial Trauma and Fracture Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
- Vitamin C and Antioxidants Research
- Pituitary Gland Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Nutrition, Genetics, and Disease
- Studies on Chitinases and Chitosanases
- Fatty Acid Research and Health
- Diet and metabolism studies
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Child Abuse and Related Trauma
- Axon Guidance and Neuronal Signaling
- COVID-19 Impact on Reproduction
Universidad de Guadalajara
2014-2025
Departamento de Salud
2022
Institute for Social Security and Services for State Workers
2017-2019
Hospital Civil de Guadalajara
2014
Mexican Social Security Institute
2007
Prenatal alcohol exposure (PAE) affects around 40,000 newborns every year and poses a significant health risk. Although much is already known about the neurotoxic mechanisms of PAE, new findings continue to emerge. Studies with mouse models show that PAE leads overexpression proinflammatory cytokines chemokines in brain, which disrupts important neurodevelopmental processes such as cell migration, survival proliferation neurons. The chemokine CXCL16 overexpressed brain following various...
Obesity generates a chronic low-grade inflammatory state which promotes oxidative stress and triggers comorbidities. Alliin is the main organosulfur compound in garlic has been shown to induce decrease expression of proinflammatory cytokines; its systemic effect on metabolic parameters adipose tissue not yet known, however. After nine weeks HFD with obesity established C57BL/6 mice, we observed that daily treatment alliin for 3.5 (15 mg/kg) did affect body weight, but significantly improved...
Prostate cancer (PCa) is the most prevalent cause of death in male population worldwide. The G Protein-Coupled Estrogen Receptor (GPER) has been gaining relevance development PCa. Hedgehog (Hh) pathway activation associated with aggressiveness, metastasis, and relapse PCa patients. To date, no studies have evaluated crosstalk between GPER Hh along different group grades We conducted an analysis paraffin-embedded tissues derived from patients prognostic grade using immunohistochemistry....
Pregnancy is a unique immunological condition in which an "immune-diplomatic" dialogue between trophoblasts and maternal immune cells established to protect the fetus from rejection, create privileged environment uterus simultaneously be alert any infectious challenge. The maternal-placental-fetal interface (MPFI) performs essential role this defense. In review, we will address MPFI as active immuno-mechanical barrier that protects against viral infections. We describe main infections...
This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by chronic administration of diethylnitrosamine (DEN) 2-acetylaminofluorene (2-AAF) Wistar rats. Thirteen rats weighing 180 200 g were divided into two groups: control treated. Rats treated group administered an intraperitoneal (i.p.) injection DEN (50 mg/kg/week) intragastric (i.g.) dose 2-AAF (25 for 18 weeks. The had significant increases their total...
Cervical cancer (CC) is the fourth leading among women and one of principal gynecological malignancies. In tumor microenvironment, cancer-associated fibroblasts (CAFs) play a crucial role during malignant progression, exhibiting variety heterogeneous phenotypes. CAFs express phenotypic markers like fibroblast activation protein (FAP), vimentin, S100A4, α-smooth muscle actin (αSMA), functional such as MMP9. This study aimed to evaluate expression αSMA, FAP, MMP9 in mesenchymal stem cells...
YKL-40 increase according to the aging process, and its functions have been associated with tissue remodeling systemic inflammation. In Rheumatoid Arthritis (RA) it has proposed as a possible biomarker of activity severity, however; in field idiopathic inflammatory myopathies (IIM) role IIM is not clear. Thus, we aimed evaluate if there an association between serum levels muscle expression age, phenotype, strength myositis disease activity. The main finding was that age most important...
During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, NRP-1 receptors, which are implicated cell differentiation, migration, proliferation. However, its involvement human development not described so far. Therefore, we investigated whether receptors were expressed during early...
In a little-known Midwest town named Rochester, Minnesota, talented physician grew in fame and respect: Dr. William Worrall Mayo, who was influential the evolution of medicine. He steadfast learner raised two sons, Charles, to follow his footsteps further medical knowledge. They were leaders surgery creation advanced sophisticated facilities. Their talents, issues surrounding practice, unexpected opportunity all came into play for Mayos. Two hospitals, St. Mary's Hospital later Methodist...
The purpose of the present study was to describe an OrBitoZygomatic (OBZ) surgical variant that implies drilling orbital roof and lateral wall orbit without orbitotomy.Design : cross-sectional study. Between January 2010 December 2014, 18 patients with middle fossa lesions underwent previously mentioned OBZ variant. Gender, age, histopathological diagnosis, complications, percentage resection were registered. detailed technique is described.Of cases listed in study, nine males females....
Abstract Background Pericoronal radiolucent lesions are a common radiographic finding, but it is rare that they occur in multiple forms. Multiple calcifying hyperplastic dental follicles (MCHDF) entities with few cases described to date; nevertheless, appear have very particular phenotypic pattern. Cases presentation Case 1: A 10-year-old male was evaluated radiographically, revealing four impacted canines, each accompanied by unilocular pericoronal radiolucency. 2: 16-year-old planning...
Multiple Sclerosis (MS) is an autoimmune-mediated disorder that affects the Central Nervous System (CNS). It associated with several genetic and environmental risk factors has a heterogeneous nature evolution of disease, as well its clinical manifestations, which rend ers difficult follow-up patients MS their treatment. As in other autoimmune diseases, sex hormones play important role MS. The prevalence proportion 2-to-3 females per males, more affected pregnancy providing protection state....
Cancer is an increasingly common disease and considered one of the main causes death in world. Lophocereus schottii (L. schottii) a cactus used Mexico traditional medicine for cancer treatment. This study aimed to determine effect ethanolic extract polar nonpolar fractions L. murine L5178Y lymphoma cells vitro, analyzing their on proliferative activity splenocytes, establishing effective concentration 50 (EC50) fraction. In addition, secondary metabolites present extracts were determined by...
Abstract The muscle fiber ultrastructure in Idiopathic Inflammatory Myopathies (IIM) has been scarcely explored, especially Inclusion Body Myositis. aim of this study was to implement the Scanning Electron Microscopy (SEM) a small cohort IIM patients, together with characterization immunological profile for better understanding pathophysiology. For characterization, we identified presence autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ,...
Macrophage migration inhibitory factor (MIF) has been associated with the pathogenesis of several rheumatic diseases. In systemic sclerosis (SSc) it shown that MIF expression is dysregulated in serum and skin. However, receptor, CD74, poorly investigated its potential role SSc remains unknown. This study aimed to analyze mRNA, tissue, CD74 patients limited (lcSSc) diffuse (dcSSc) sclerosis. A case-control 20 control subjects (CS) from southern México was conducted. mRNA levels were...
There is a little information about of expression C4d (complement fragment) in Focal segmental glomerulosclerosis (FSGS) subtypes. Our aim was to determine the FSGS subtypes percutaneous native renal biopsies second-level hospital and its correlation with clinical, biochemical histological variables. A retrospective study paraffin blocks patients biopsy aged 16–65 years, indistinct sex, not diabetic or obese. Immunohistochemistry performed for their analyzing non-sclerosed glomerular...
Trigeminal neuralgia (TN) is a neuropathic disorder that can be treated surgically. This study aimed to present the surgical findings and clinical outcomes of 26 patients with TN by minimally invasive asterional surgery.Longitudinal descriptive study. Twenty-six underwent surgery. The medical history, findings, therapeutic response, complications were registered. They followed for 36 months.Nineteen cases associated vascular compression; five arachnoiditis. two remaining multiple sclerosis...
Maternal ethanol consumption during pregnancy is one of the main causes Neurodevelopmental disorders (NDD). Prenatal alcohol exposure (PAE) produces several adverse manifestations. Even low or moderate intake has been associated with long-lasting behavioral and cognitive impairment in offspring. In this study we examined gene expression profile rat nucleus accumbens using microarrays, comparing animals exposed prenatally to controls. Microarray showed an overall downward regulatory effect...
Trigeminal neuralgia (TN) is a neuropathic disorder that can be treated surgically. This study aimed to present the surgical findings and clinical outcomes of 26 patients with TN by minimally invasive asterional surgery.Longitudinal descriptive study. Twenty-six underwent surgery. The medical history, findings, therapeutic response, complications were registered. They followed for 36 months.Nineteen cases associated vascular compression; five arachnoiditis. two remaining multiple sclerosis...