A5062504168- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Vitamin D Research Studies
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Diet and metabolism studies
- Galectins and Cancer Biology
- Renal and related cancers
- Immunodeficiency and Autoimmune Disorders
- Electrolyte and hormonal disorders
- Estrogen and related hormone effects
- Cardiovascular Issues in Pregnancy
- HIV Research and Treatment
- Congenital Anomalies and Fetal Surgery
- Sirtuins and Resveratrol in Medicine
- Infant Nutrition and Health
- Maternal and fetal healthcare
- Organ and Tissue Transplantation Research
- Pregnancy-related medical research
- Antimicrobial Peptides and Activities
- Blood groups and transfusion
- Prostate Cancer Treatment and Research
Instituto Nacional de Perinatología
2017-2024
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2010-2021
Universidad Nacional Autónoma de México
2016
Calcitriol is a multitarget anticancer hormone; however, its effects on angiogenesis remain contradictory. Herein, we tested whether the antiangiogenic phytochemicals curcumin or resveratrol improved calcitriol antitumorigenic in vivo. Triple-negative breast cancer tumoral cells (MBCDF-T) were xenografted nude mice, maintaining treatments for 3 weeks. Tumor onset, volume and microvessel density significantly reduced mice coadministered with (Cal+Cur). Vessel count was also simultaneously...
Prolactin (PRL) plays an important role in trophoblast growth, placental angiogenesis and immunomodulation within the feto-maternal interface, where different cell types secrete PRL express its receptor. During pregnancy, inflammatory signalling is a deleterious event that has been associated with poor fetal outcomes. The placenta highly responsive to stimulus; however, actions of immunity inflammation remain largely unknown. aim this study was evaluate effects on TLR4/NFkB cascade targets...
Pregnancy is a unique immunological condition in which an "immune-diplomatic" dialogue between trophoblasts and maternal immune cells established to protect the fetus from rejection, create privileged environment uterus simultaneously be alert any infectious challenge. The maternal-placental-fetal interface (MPFI) performs essential role this defense. In review, we will address MPFI as active immuno-mechanical barrier that protects against viral infections. We describe main infections...
The aim of this study was to investigate the associations between insulin-like growth factor I (IGF-I) with vascular endothelial (VEGF) and its soluble receptor 1 (sFlt-1) in umbilical serum effects IGF-I upon sFlt-1 synthesis human vein cells (HUVEC) normotensive (NT) preeclamptic (PE) pregnancies. As compared NT group, VEGF levels were lower PE while concentrations higher. Levels correlated group group. Basal concentration HUVEC culture media higher stimulated only In summary, is...
An infectious process into the uterine cavity represents a major endangered condition that compromises immune privilege of maternal-fetal unit and increases risk for preterm birth (PTB) premature rupture membranes (PROM). Fetal are active secretors antimicrobial peptides (AMP), which limit bacterial growth, such as Escherichia coli. Nevertheless, antibacterial responses displayed by chorioamniotic against choriodecidual E. coli infection have been briefly studied. The objective this research...
Over the last 20 years, incidence of vertical HIV transmission has decreased from 25%–42% to less than 1%. Although there are no signs infection, health HIV-exposed uninfected (HEU) infants is notoriously affected during first months life, with opportunistic infections being most common disease. Some studies have reported effects on transfer antibodies, but little known about subclass distribution these antibodies. We proposed evaluate total IgG concentration and its subclasses in HIV+...
Problem Calcitriol, the hormonal form of vitamin D 3 ( VD ), stimulates placental antimicrobial peptides expression; nonetheless, regulation calcitriol biosynthesis in presence bacterial products and its consequence on innate immunity have scarcely been addressed. Method study We investigated how some modify metabolism ability to induce gene expression. Results Cultured human trophoblasts biosynthesized only precursor calcidiol, a process that was inhibited by cyclic‐ AMP but stimulated...
Placentas from gestational diabetes mellitus (GDM) patients undergo significant metabolic and immunologic adaptations due to hyperglycemia, which results in an exacerbated synthesis of proinflammatory cytokines increased risk for infections. Insulin or metformin are clinically indicated the treatment GDM; however, there is limited information about immunomodulatory activity these drugs human placenta, especially context maternal Our objective was study role insulin placental inflammatory...
Background: Inflammation is a condition that jeopardizes the continuity of pregnancy because it increases secretion chemokines favor migration leukocytes from maternal and fetal circulations to cervix, placenta, chorioamniotic membranes. During pregnancy, level prolactin (PRL) in amniotic fluid high; there evidence suggest PRL contributes maintain privileged immune environment cavity. We test effect on profile human membranes.Methods: Nine membranes collected healthy nonlabouring cesarean...
Abstract Problem Immune responses of fetal membranes involve the production chemoattractant mediators causing infiltration maternal and leukocytes, intrauterine inflammation potentially disruption maternal‐fetal tolerance. Prolactin (PRL) has deep immunoregulatory effects in fetal‐maternal interface. We aimed to test vitro PRL effect upon chemotactic capacities human membranes. Method Study Fetal umbilical cord blood were collected from healthy non‐laboring caesarean deliveries at term....
The cAMP pathway is involved in important biological processes including immune regulation and hormone signaling. At the feto-maternal unit, participates placental function/physiology establishment of immunoendocrine networks. Low male fetuses cord blood has been linked to poorer perinatal outcomes; however, content its relationship with factors fetal sex an infectious condition have not investigated.Sex-dependent changes association cytokines antimicrobial peptides expression were studied...