Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects on neurogenesis capacity in a mouse model Alzheimer's disease. disease models were established by injection beta amyloid 1−42 aggregates into dentate gyrus bilaterally. Morris water maze novel object recognition tests performed evaluate deficits at 14 28 days after administration. Afterwards, subventricular...

Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such learning memory. In neurodegenerative diseases, spine morphology alteration, shape density, affects functional characteristics leading dysfunction impairment. Recent evidence implicates a critical feature pathogenesis dementia, particularly Alzheimer's disease. The alteration their loss is...

Fructans are dietary fibers with beneficial effects on the gastrointestinal physiology and offer a promising approach for treatment of some metabolic disorders associated obesity. In vitro in vivo studies were developed to test safety fructans obtained from Agave tequilana Weber var. azul. Additionally, an experiment using diet-induced obesity model was performed compare effect agave different degree polymerization (DP) profiles: DP > 10 (LcF), FOS < (ScF), without demineralization (dTF, TF)...

The growing incidence of obesity is a worldwide public health problem leading to risk factor for non-alcoholic fatty liver disease, which extends from steatosis steatohepatitis and cirrhosis. We investigated whether the aqueous extract Hibiscus sabdariffa L. (Hs) reduces body weight gain protects by improving lipid metabolism in high fat diet-induced obese C57BL/6NHsd mice. found that oral administration Hs reduced tissue accumulation, diminished normalized glycemic index as well...

A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with high intake of simple sugars, saturated fat, physical inactivity, promotes pathologic conditions. main adverse consequences range from cardiovascular disease, type 2 diabetes, metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways many different functional foods have been associated various benefits when consumed. Natural...

Fructans from agave have received specific attention because of their highly branched fructan content. We previously reported that the degree polymerization (dp) influences biological activity. Therefore, aim this study was to investigate effect unfractionated and fractionated fructans (higher lower dps) Agave tequilana in high-fat diet-induced (HFD) obese mice. with a dp (HFD+ScF) decreased weight gain by 30 %, body fat mass 51 hyperglycemia 25 % liver steatosis 40 %. Interestingly, (HFD+F)...

Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory neuronal loss, caused mainly extracellular deposition of amyloid-β (Aβ) intracellular accumulation hyperphosphorylated tau protein, primarily in areas implicated learning as prefrontal cortex hippocampus. There are two forms AD, late-onset form that affects people over 65 years old, the early-onset form, which hereditable affect at early ages ~45 years. To date, there no cure for...

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core γ-secretase complex that conducts intramembranous proteolytic excision multiple transmembrane proteins like amyloid precursor protein, Notch-1, N- E-cadherin, LRP, Syndecan, Delta, Jagged, CD44, ErbB4, Nectin1a. plays an...

Abstract Immunotherapies based on antibody fragments have been developed and applied to human diseases, describing novel formats. The vNAR domains a potential therapeutic use related their unique properties. This work used non-immunized Heterodontus francisci shark library obtain with recognition of TGF-β isoforms. isolated T1 selected by phage display demonstrated binding the isoforms (-β1, -β2, -β3) direct ELISA assay. These results are supported using for first time Single-Cycle kinetics...

Chronic kidney disease (CKD) causes anemia by renal damage. In CKD, the is submitted to hypoxia, persistent inflammation, leading fibrosis and permanent loss of function. Human recombinant erythropoietin (rEPO) has been widely used treat CKD-associated known possess organ-protective properties that are independent from its well-established hematopoietic effects. Nonhematopoietic effects EPO mediated an alternative receptor proposed consist a heterocomplex between (EPOR) beta common ( β cR)....

Abstract Background Dominant‐negative transforming growth factor β type II receptor (TβRIIΔcyt) is a protein that blocks (TGF‐β) signaling. Because the consequences of blocking TGF‐β have not been completely elucidated in liver fibrosis, we analysed effects adenoviral delivery TβRIIΔcyt on profibrogenic genes and matrix metalloproteinase (MMP) proteins, as well signal repressor SKI‐like oncogene (SnoN), cultured hepatic stellate cells (HSCs) rat model fibrosis. Methods To induce rats were...

Rheumatoid arthritis (RA) patients might experience anxiety and depressive symptoms. Deficient vitamin D levels may be a trigger for these conditions. The aim of this study was to determine the frequency depression, symptoms, suicidal risk or ideation in with RA associated serum levels.

Capsaicin, the major component of chili peppers, has shown potential therapeutic effect against metabolic disease inducing weight loss. Its is exerted by a particular molecular mechanism and pharmacodynamics, distinct to current obesity treatments. However, its high irritating taste or pungency limited use some clinical trials. Capsaicin-like molecules, known as capsaicin synthetic analogs, contain majority domains but without those pungency. Recently, they have received much attention their...

BackgroundExperimental liver fibrosis induced by carbon tetrachloride (CCl4) is associated with oxidative stress, lipid peroxidation, and inflammation. This work was focused on elucidating the anti-inflammatory antioxidant effects of ethylenediaminetetraacetic acid (EDTA) in this model hepatotoxicityMethodsWistar male rats were treated CCl4 EDTA (60, 120, or 240 mg/kg). Morphometric analyses carried out Masson's stained sections to determine index. Coagulation tests prothrombin time (PT)...

Obesity is an abnormal or excessive accumulation of fat in the body that exacerbates metabolic and inflammatory processes, impairs health afflicted individuals. β-caryophyllene a natural sesquiterpene dietary cannabinoid with anti-inflammatory properties potential activity against diseases. In present study, we evaluated effect on C57BL/6 mice using diet-induced obesity model. Male were randomly assigned to following groups over 16-week period: (1) standard diet as lean control, (2) high-fat...

Parkinson's disease is a progressive neurodegenerative disorder characterised by loss of dopaminergic neurons in the substantia nigra pars compacta, which results significant decrease dopamine levels and consequent functional motor impairment. Although its aetiology not fully understood, several pathogenic mechanisms, including oxidative stress, have been proposed. Current therapeutic approaches are based on replacement drugs; these agents, however, able to stop or even slow progression....

Tuberculosis causes close to 1.5 million deaths in the world, with new cases exceeding 9 recent years. Coinfection HIV further worsens global situation. New molecules that overcome limitations of currently used drugs are needed. We aimed determine whether HHC-10 is active against Mycobacterium tuberculosis complex bacteria bovis bacille calmette guerin (BCG) vitro and vivo. For this, was tested using different peptide concentrations, vivo, C57BL/6 mice infected intratracheally, at two doses...

YKL-40 increase according to the aging process, and its functions have been associated with tissue remodeling systemic inflammation. In Rheumatoid Arthritis (RA) it has proposed as a possible biomarker of activity severity, however; in field idiopathic inflammatory myopathies (IIM) role IIM is not clear. Thus, we aimed evaluate if there an association between serum levels muscle expression age, phenotype, strength myositis disease activity. The main finding was that age most important...