Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects on neurogenesis capacity in a mouse model Alzheimer's disease. disease models were established by injection beta amyloid 1−42 aggregates into dentate gyrus bilaterally. Morris water maze novel object recognition tests performed evaluate deficits at 14 28 days after administration. Afterwards, subventricular...

Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such learning memory. In neurodegenerative diseases, spine morphology alteration, shape density, affects functional characteristics leading dysfunction impairment. Recent evidence implicates a critical feature pathogenesis dementia, particularly Alzheimer's disease. The alteration their loss is...

Glioblastoma is the most common and highly malignant brain tumor in adults. New targeted therapeutic approaches are imperative. EGFRvIII has appealing targets using monoclonal antibodies. Thus, endeavors toward developing new mAbs therapies for GBM capable of targeting biomarker must prevail to improve patient’s prognosis. Here, we isolated characterized an anti-EGFRvIII vNAR from a non-immune freshwater stingray mixed library, termed R426. The R426 pEGFRvIII interaction was demonstrated by...

The discovery and design of antiviral agents have gained unprecedented significance due to the emergence global health threats. use synthetic chemistry has enabled modification existing molecules creation entirely novel compounds. In our laboratory, we enzymatically synthesized a bioconjugate, lithocholic acid oleate (LO), derived from (LCA), bile that been proven by researchers exhibit activity in vitro. study presented herein describes preparative synthesis, formulation, evaluation LO both...

Glioblastoma (GBM) is a highly aggressive and malignant brain tumor, characterized by hypoxia in its microenvironment, which drives growth resistance to treatments. Hypoxia-inducible factor 1 (HIF-1) plays central role GBM progression regulating cellular adaptation low oxygen availability, promoting processes such as angiogenesis cell invasion. However, studying modeling under hypoxic conditions complex, especially due the limitations of animal models. In this study, we developed glioma...

The growing incidence of obesity is a worldwide public health problem leading to risk factor for non-alcoholic fatty liver disease, which extends from steatosis steatohepatitis and cirrhosis. We investigated whether the aqueous extract Hibiscus sabdariffa L. (Hs) reduces body weight gain protects by improving lipid metabolism in high fat diet-induced obese C57BL/6NHsd mice. found that oral administration Hs reduced tissue accumulation, diminished normalized glycemic index as well...

There is considerable controversy with regard to the genotoxicity of glyphosate, some reports stating that this compound non-toxic for fish, birds and mammals. In work, we used comet assay examine glyphosate isopropylamine (0.7, 7, 70 700 μM) in human lymphocytes, erythrocytes Oreochromis niloticus staminal nuclei Tradescantia (4430) vitro vivo. Cells, fish had not been exposed 5 mM N-nitrosodiethylamine (NDEA) were as positive negative controls, respectively. Significant (p < 0.01) genetic...

Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory neuronal loss, caused mainly extracellular deposition of amyloid-β (Aβ) intracellular accumulation hyperphosphorylated tau protein, primarily in areas implicated learning as prefrontal cortex hippocampus. There are two forms AD, late-onset form that affects people over 65 years old, the early-onset form, which hereditable affect at early ages ~45 years. To date, there no cure for...

One of the main concerns regarding organophosphate pesticides (OP) is their possible toxic effects. Doses that do not produce acute toxicity are capable altering structure and biochemistry different tissues organs by production reactive oxygen species (ROS). Curcumin (CUR) substance in Curcuma longa (Zingiberacea) rhizome has strong antioxidant activity. However, neuroprotective properties curcumin against oxidative stress induced prolonged exposure to parathion (PAR) clear.The present work...

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core γ-secretase complex that conducts intramembranous proteolytic excision multiple transmembrane proteins like amyloid precursor protein, Notch-1, N- E-cadherin, LRP, Syndecan, Delta, Jagged, CD44, ErbB4, Nectin1a. plays an...

Globally, the rise in neurodegenerative issues tandem with shifts lifestyle and aging population has prompted a search for effective interventions. Nutraceutical compounds have emerged as promising agents addressing these challenges. This 60-day study on an aluminum-induced cognitive impairment rat model assessed three their combinations: probiotics (Prob, Lactobacillus plantarum [5 × 1010 CFU/day], acidophilus CFU/day]), docosahexaenoic acid (DHA, 23.8 mg/day), vitamin D3 (VD3, 150 IU/day)....

The genotoxicity of some environmental contaminants may affect human health directly by damaging genetic material and thus plays an important role in cancer development. Xenoestrogens are one kind pollutants that alter hormonal routes or DNA. number available biomarkers used to assess risk is very extensive. present study evaluated produced the pesticide DDT on systemic mammary gland cells obtained from adult female Wistar rats. Oral mucosa micronuclei were assessed; comet assay peripheral...

Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial, antioxidant, among others. However, these properties in peel have been poorly explored. Aims: Evaluate the healing activity induced by an incision model using methanolic, hexanoic and chloroformic extracts from M. peel. Methods: Dehydrated paradisíaca was mixed with methanol, hexane, chloroform. The presence of bioactive substances carried out Trease Evans...

Chronic kidney disease (CKD) causes anemia by renal damage. In CKD, the is submitted to hypoxia, persistent inflammation, leading fibrosis and permanent loss of function. Human recombinant erythropoietin (rEPO) has been widely used treat CKD-associated known possess organ-protective properties that are independent from its well-established hematopoietic effects. Nonhematopoietic effects EPO mediated an alternative receptor proposed consist a heterocomplex between (EPOR) beta common ( β cR)....