A5068123453- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
- Neuroscience and Neuropharmacology Research
- Redox biology and oxidative stress
- Neurobiology of Language and Bilingualism
- Astronomy and Astrophysical Research
- Gaze Tracking and Assistive Technology
- EEG and Brain-Computer Interfaces
- Biochemical effects in animals
- Higher Education Teaching and Evaluation
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Lipid Membrane Structure and Behavior
- Neurogenesis and neuroplasticity mechanisms
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Medicinal Plants and Bioactive Compounds
- Neurological Disease Mechanisms and Treatments
- E-Learning and Knowledge Management
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Stroke Rehabilitation and Recovery
- Olfactory and Sensory Function Studies
Universidad de Guadalajara
2017-2025
Hospital Universitario La Paz
2016
Mexican Social Security Institute
2006-2013
Hospital Universitario Ramón y Cajal
2011-2012
Instituto Ramón y Cajal de Investigación Sanitaria
2011-2012
Tecnológico de Monterrey
2012
Secretaría de Salud de Jalisco
2006
Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such learning memory. In neurodegenerative diseases, spine morphology alteration, shape density, affects functional characteristics leading dysfunction impairment. Recent evidence implicates a critical feature pathogenesis dementia, particularly Alzheimer's disease. The alteration their loss is...
Background and purpose: Therapy for stroke with intravenous tissue plasminogen activator (IV‐tPA) is hampered by tight licensing restrictions; some of them have been discussed in recent literature. We assessed the safety effectiveness off‐label IV‐tPA clinical settings. Methods: Retrospective analysis all patients treated at our Stroke Unit. Patients were divided into two groups licence criteria [on‐label group (OnLG), (OffLG)]. Primary outcome measures symptomatic intracranial haemorrhages...
<b><i>Background:</i></b> Patients who present with symptoms mimicking ischaemic stroke (IS), but have a different diagnosis, are known as mimics (SM). The necessity for rapid administration of intravenous thrombolysis in patients acute IS may lead to treatment conditions stroke. A variable proportion SM (1.4–14%) currently treated tissue plasminogen activator therapy (IV-tPA). outcome these is generally favourable and complications rather infrequent. We aimed...
Alzheimer's disease (AD), the most common neurodegenerative and first cause of dementia worldwide, has no effective treatment, its pathological mechanisms are not yet fully understood. We conducted this study to explore proteomic differences associated with Familial Disease (FAD) in olfactory ecto-mesenchymal stem cells (MSCs) derived from PSEN1 (A431E) mutation carriers compared healthy donors paired by age gender through two label-free liquid chromatography-mass spectrometry approaches....
It has been suggested that mitochondrial dysfunction and defects in membrane structure could be implied AD pathogenesis. The aim of the present work was study fluidity submitochondrial platelet particles erythrocyte membranes from Mexican patients. Blood samples were obtained 30 patients with Alzheimer disease aged‐matched control subjects. Membrane determinations done using a very low concentration fluorescent dipyrenylpropane probe incorporated both types membranes. This is able to give...
Decreased Choline Acetyltransferase (ChAT) brain level is one of the main biochemical disorders in Alzheimer's Disease (AD). In rodents, recent data show that CHAT gene can be regulated by a neural restrictive silencer factor (NRSF). The aim present work was to evaluate and protein expression NRSF frontal, temporal, entorhinal parietal cortices AD patient brains. Four brains from patients with four subjects without dementia were studied. Cerebral tissues obtained processed guanidine...
Esta investigación exploró la integración de Competencias Digitales Emergentes (CDE) en un programa Doctorado Biociencias, con enfoque particular las tecnologías digitales. El estudio se centró estrategias para incorporar tecnología digitales el currículo. Se utilizó cualitativo basado Análisis Crítico del Discurso. Además, recopilaron datos mediante entrevistas y análisis documental. La destacó importancia CDE, como datos, bioinformática uso inteligencia artificial formación investigadores....
Laboratorio Desarrollo-Envejecimiento; Enfermedades Neurodegenerativas. Division de Neurociencias. Centro Investigacion Biomedica Occidente (CIBO). Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jal. Mexico Departamento Biologia molecular y genomica. Universitario Ciencias la Salud (CUCS). Universidad Guadalajara. Quimica. Exactas e Ingenierias. Neurologia. Unidad Medica Alta Especialidad (UMAE). Hospital Especialidades (HE). Medico Nacional (CMNO), IMSS, Mexico. Departamento...
Objective : To determine the β ‐amyloid precursor protein ( APP) isoforms ratio as a risk factor for Alzheimer’s Disease and to assess its relationship with demographic genetic variables of disease. Methods Blood samples from 26 patients fulfilling NINCDS‐ADRDA diagnostic criteria AD 46 healthy control subjects were collected Western blotting APP. A APP isoforms, in optical densities, between upper band (130 Kd) lower bands (106–110 was obtained. Odds ratios obtained this component. Results...
The Electroencephalographic signals are commonly used for developing brain-machine interfaces (BMI), in fact is the most biological signal to translate brain's commands computer. Some additional physiological measures have been along with EEG order obtain more robust and accurate BMI systems. However, since very sophisticated recording devices available, processing getting complicated, mainly due invested computational time extraction pattern recognition. Therefore, could be too long, which...
Background and purpose. Intravenous administration of recombinant tissue plasminogen activator (rtPA) is approved for the treatment patients with acute ischemic stroke. It still controversial if in stroke due to atrial fibrillation this has same efficacy as other etiologies. The present study aimed compare safety outcome intravenous thrombolysis rtPA between fibrillation, cardiac sources emboli large-vessel disease. Methods. Retrospective analysis 463 treated Stroke Unit Ramon y Cajal...
The Alzheimer disease (AD) is the main cause of dementia in world, constitutes one most common forms senile and presenile ageing subjects. attention has gone to possible contribution mitochondrial dysfunction, it been suggested that some defects metabolism could be implied pathogenesis AD. aim present work was study membrane fluidity sub-mitochondrial platelet particles erythrocyte membranes from Mexican patients with probable. Blood samples were obtained 30 who attended Hospital de...