A5084669855- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Acute Ischemic Stroke Management
- Mitochondrial Function and Pathology
- Cerebral Palsy and Movement Disorders
- Venous Thromboembolism Diagnosis and Management
- Balance, Gait, and Falls Prevention
- Multiple Sclerosis Research Studies
- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Cardiovascular Syncope and Autonomic Disorders
- RNA Research and Splicing
- Hereditary Neurological Disorders
- Advanced Biosensing Techniques and Applications
- Lysosomal Storage Disorders Research
- Nerve injury and regeneration
- Antiplatelet Therapy and Cardiovascular Diseases
- Virus-based gene therapy research
- Neurogenetic and Muscular Disorders Research
- Cardiac pacing and defibrillation studies
- Biotin and Related Studies
Clinica Rotger
2018-2024
Hospital Universitario Ramón y Cajal
2011-2018
Hospital Universitario Fundación Jiménez Díaz
2014-2017
Instituto Cajal
2013-2014
Instituto Ramón y Cajal de Investigación Sanitaria
2011-2014
Universidad de Alcalá
2012
Background and purpose: Therapy for stroke with intravenous tissue plasminogen activator (IV‐tPA) is hampered by tight licensing restrictions; some of them have been discussed in recent literature. We assessed the safety effectiveness off‐label IV‐tPA clinical settings. Methods: Retrospective analysis all patients treated at our Stroke Unit. Patients were divided into two groups licence criteria [on‐label group (OnLG), (OffLG)]. Primary outcome measures symptomatic intracranial haemorrhages...
Background and purpose Cerebrospinal fluid ( CSF ) neurofilament light protein NFL is a promising biomarker of axonal injury neurodegeneration. Here lymphocyte subpopulations antibodies, potential players neurodegeneration, are examined in relation to shedding MS . Methods from 127 consecutive untreated patients was analysed. Samples 37 age‐matched with other central nervous system non‐inflammatory neurological diseases NIND were also assessed. CD 4+, 8+, 56+ 19+ cell subsets studied by flow...
Hereditary spastic paraplegias constitute a heterogeneous group of neurodegenerative diseases encompassing pure and complicated forms, for which at least 52 loci 31 causative genes have been identified. Although mutations in the SPAST gene explain approximately 40% autosomal dominant molecular diagnosis can be challenging sporadic recessive are often clinically overlap with broad number movement disorders. The validity exome sequencing as routine diagnostic approach disorder clinic needs to...
Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on status may help prevent dementia (PDD) design trials.Using a standard approach assessment global cognition PD controlling effects age, education duration, we explored associations between status, comorbidities, metabolic variables lifestyle 533 participants from COPPADIS study.Among overall sample, 21% were classified as PD-MCI (n = 114) 4% PDD 26). The...
Abstract Background A recent genome‐wide association study (GWAS) has identified a putative association, not statistically confirmed, of cervical dystonia within several regions in British population. Hence, the authors proposed dysfunction ion channel NALCN (for sodium leak channel, nonselective) as plausible cause dystonia. The objective our was to investigate five single nucleotide polymorphisms (SNPs) previously reported with high signals genetic risk factors for GWAS, including two...
Background and Purpose. Intravenous thrombolysis using tissue plasminogen activator is safe probably effective in patients >80 years old. Nevertheless, its safety has not been specifically addressed for the oldest old (≥85 old, OO). We assessed effectiveness of this group age. Methods. A prospective registry treated with intravenous thrombolysis. Patients were divided two groups (<85 Demographic data, stroke aetiology baseline National Institute Health Stroke Scale (NIHSS) score...
<b><i>Background:</i></b> Parkinson’s disease (PD) patients are known to suffer from subtle cognitive and balance deficits the early stages although they usually manifest in advanced stages. Postural instability (PI) has been correlated with slower information processing speed. Simple reaction time (SRT) tasks can be used measure speed of processing. The main objective this study was examine usefulness SRT as a valid predictor PD, thus providing simple complementary...
Abstract Background Repetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson’s disease (PD). However, the effects of their combination are unknown. Our objective was to determine immediate short-term on non-motor symptoms, neurophysiological measures, rTMS neurofeedback, alone or combined, compared no intervention, people with PD. Methods A randomized, single-blinded controlled trial 4 arms conducted. Group received...
Neurofilament light proteins (NFL) are a structural element of the neuronal cytoskeleton and released with damage. Its levels increased in cerebrospinal fluid (CSF) setting neurodegenerative diseases. We investigated CSF-NFL Huntington´s disease (HD) patients (participating clinical trial SAT-HD) as well premanifest carriers compared their results sample healthy controls correlated demographic variables (baseline characteristics HD measures severity). CSF were significantly higher all...
Botulinum toxin type A (BTA) is a bacterial endotoxin, whose therapeutic use has had dramatic impact on different neurological disorders, such as dystonia and spasticity.To analyze summarize questions about the of BTA in our clinical practice.A group experts neurology developed list topics related with BTA. Two groups were considered: neuropharmacology dystonia. literature search at PubMed, mainly for English language articles published up to June 2016 was performed. The manuscript...
<h3>Introduction</h3> Light subunit of neurofilament protein (NFL) is a structural element neurons. Its levels are increased in cerebrospinal fluid (CSF) the setting neurological diseases, including Huntington’s disease (HD), and considered marker neuronal damage. HD paradigm neurodegeneration need appropriate biomarkers. <h3>Objectives</h3> To compare CSF-NFL patients healthy controls. correlate with demographic clinical variables. <h3>Methods</h3> The ELISA for NFL was performed according...
<h3>Background</h3> We conducted a pilot trial to assess the safety and tolerability of Sativex in HD (SAT-HD). Several biomarkers were studied order detect putative sub-clinical molecular effects cannabinoids. <h3>Aims</h3> Here we present results CSF analysis, as indicated protocol, all twenty four patients who underwent two optional lumbar punctures [11 women, mean age 47.3 (SD 12.3); CAG 45.9 (3.5); mUHDRS 24 (11.4), fUHDRS 18 (4.6), bUHDRS 15.1 (7.1), NPI 10 (5.5), DB 462.7 (107.4)]....
OBJECTIVE: To explore CSF cellular and molecular immunological biomarkers associated with increased levels of neurofilament light protein (NfL) in multiple sclerosis (MS).