A5044321944- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Multiple Sclerosis Research Studies
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Genetic Neurodegenerative Diseases
- Pituitary Gland Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Lysosomal Storage Disorders Research
- Trigeminal Neuralgia and Treatments
- Ophthalmology and Eye Disorders
- Cytokine Signaling Pathways and Interactions
- Photoreceptor and optogenetics research
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Bullous Skin Diseases
- Nerve injury and regeneration
- Migraine and Headache Studies
- Psoriasis: Treatment and Pathogenesis
- Trypanosoma species research and implications
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Autism Spectrum Disorder Research
- Polyomavirus and related diseases
Biomedical Research and Innovation Institute of Cadiz
2021-2024
Foundation for Biomedical Research and Innovation
2024
Hospital Jerez Puerta del Sur
2022-2024
Hospital Universitario Puerta del Mar
2000-2022
Instituto de Investigación Biomédica de A Coruña
2022
Universidad de Cádiz
2021
To determine the relative importance of global or regional MRI and blood markers neurodegeneration neuroaxonal injury in predicting cognitive performance for recently diagnosed patients with multiple sclerosis (MS).Thirty-five newly relapsing-remitting MS (RRMS) 23 healthy controls (HCs) simultaneously completed a full clinical neuropsychological assessment, structural brain MRI, serum neurofilament light chain (sNfL) level test. Linear regression analyses were performed to which measures...
Abstract Background A recent genome‐wide association study (GWAS) has identified a putative association, not statistically confirmed, of cervical dystonia within several regions in British population. Hence, the authors proposed dysfunction ion channel NALCN (for sodium leak channel, nonselective) as plausible cause dystonia. The objective our was to investigate five single nucleotide polymorphisms (SNPs) previously reported with high signals genetic risk factors for GWAS, including two...
Abstract SARS-CoV-2 infection often involves the nervous system, leading to cognitive dysfunctions, fatigue, and many other neurological signs that are becoming increasingly recognized. Despite mild forms of disease accounting for most cases worldwide, research on pathophysiology driving COVID-19 has received little attention. In this respect, recent evidence pointed out around 30–40% non-critical, mild-to-moderate severity survivors may display disturbances several months post-illness....
This study aimed to examine the presence of neuropsychological deficits and their relationships with clinical, pharmacological, neuropsychiatric characteristics in chronic migraine (CM) patients assessed during a headache-free period. We enrolled 39 CM (mean age: 45.4 years; male/female ratio: 3/36) 20 age-, sex-, education-matched healthy controls (HCs, mean 45.5 2/18) case–control study. All underwent full extensive neuropsychiatric, evaluation evaluate cognitive domains, including...
Neoplasm development in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs) has been widely discussed. The aim of this work is to determine neoplasm frequency, relationship the prescription pattern DMTs, and influence patients' baseline characteristics. Data from 250 MS outpatients were collected during period 1981-2019 medical records Neurology Service HUPM (Hospital Universitario Puerta del Mar)-in Southern Spain-and analysed using Cox models. prevalence was...
This retrospective observational study aimed to define neuropsychological impairment (NI) profiles and determine the influence of clinical, demographic, neuropsychiatric measures in specific cognitive domains a cohort relapsing-remitting multiple sclerosis (RRMS) patients.Ninety-one RRMS patients underwent neurological examination brief assessment. Patients were classified according disease-modifying therapies (DMTs) received (platform or high-efficacy). Differences between groups regression...
Sneddon syndrome is a rare systemic vasculopathy affecting the skin as livedo racemosa and central nervous system stroke. A 31-year-old man with history of presented partial left third nerve palsy. Skin biopsy showed signs endotheliitis obliteration dermal blood vessels due to intimal proliferation fibrin thrombi consistent syndrome. The patient was treated platelet antiaggregant therapy complete resolution his Clinicians should be aware because prompt diagnosis treatment may prevent...
Inverse psoriasis is characterized by the development of erythematous shiny plaques at intertriginous areas body. It has a prevalence 2% worldwide. The usefulness levodopa in was discovered 1970 but nowadays it not standard therapy for this condition. A 74-year-old woman diagnosed with Parkinson's disease subsequent to extensive inverse psoriasis. skin lesions were resistant classical topical and systemic medications. Treatment initiated order treat her neurological problem progressive...
RESUMEN: No existen demasiados
Excessive oscillations at beta frequencies (13-35 Hz) in the subthalamic nucleus (STN) represent a pathophysiological hallmark of Parkinson's disease (PD), which correlates well with parkinsonian symptoms and is reduced response to standard treatments. However, association disease-specific regional gray matter (GM) atrophy or cortical thickness (CT) presence STN oscillatory activity has been poorly investigated but relevance given potential these variables for extracting information about PD...
The ability of serum biomarkers to predict the prognosis and response deep-brain stimulation (DBS) therapy in Parkinson's disease (PD) patients is promising. Here, we showed that NfL differed between healthy individuals PD changes NfL, GFAP, BDNF occurred only transiently after DBS surgery. Therefore, subthalamic does not promote neurodegeneration, these do serve as clinical improvement endpoints patients.
Background and objectives Intermittent theta-burst stimulation (iTBS) is a patterned form of excitatory transcranial magnetic that has yielded encouraging results as an adjunctive therapeutic option to alleviate the emergence clinical deficits in Parkinson’s disease (PD) patients. Although it been demonstrated iTBS influences dopamine-dependent corticostriatal plasticity, little research examined neurobiological mechanisms underlying iTBS-induced enhancement. Here, our primary goal verify...
Pompe disease is a generalized progressive caused by deficiency of the lysosome enzyme acid alpha-glucosidase (GAA). We present three cases with different clinical symptomatology and treated replacement therapy (ERT) positive evolution.Case 1: three-month old male, weakness rejecting meals; mild hepatomegaly, discrete macroglossia muscular hypotony; increased enzymes. Case 2: five-month delayed motor development, severe neurosensory deafness, respiratory disorder difficult evolution;...
Pompe disease or glycogen storage type II is the accumulation of in muscle tissue due to a defi ciency lysosomal acid maltase.Today it considered be rare disease, untreated until 2006.Prevalence 1 case per 60,000 habitants, incidence 100,000 population year.The causes severe cardiorespiratory and muscular disabilities.We report diagnosed Universitary Hospital Puerta del Mar (Cadiz, Spain), treated multidisciplinary way, with emphasis on effect pulmonary rehabilitation increasing respiratory...