A5047004228- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Nuclear Receptors and Signaling
- Glycogen Storage Diseases and Myoclonus
- Neurotransmitter Receptor Influence on Behavior
- Alcoholism and Thiamine Deficiency
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Neurological Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Autism Spectrum Disorder Research
- Autoimmune Neurological Disorders and Treatments
- Metabolism and Genetic Disorders
- Neuroscience of respiration and sleep
- Cardiovascular Syncope and Autonomic Disorders
- Tissue Engineering and Regenerative Medicine
Navarre Institute of Health Research
2015-2025
Clinica Universidad de Navarra
2015-2025
Universidad de Navarra
2012-2023
Weatherford College
2022
Hospital de León
2014
Parc Científic de la Universitat de València
2009
Hospital Universitario Príncipe de Asturias
2006
University of Pamplona
2006
Inserm
1993
University of Manchester
1990
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution synucleinopathy correlates with predominant clinical features, burden pathology does not fully explain observed differences in presentation rate disease progression. We hypothesized that heterogeneity MSA consequence variability seeding activity α-synuclein both between...
Nineteen Macaca fascicularis monkeys were divided into four different groups: Group A (n = 3), control; B treated with I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); C 8), animals MPTP in which the subthalamic nucleus (STN) was unilaterally lesioned by kainic acid injection; D 5), STN prior to administration. Subthalamotomy resulted a bilateral improvement of tremor, spontaneous activity, bradykinesia (evaluated manual motor test) and freezing C. All these developed hemichorea...
Levodopa-induced dyskinesias (LID) in Parkinson's disease (PD) may be classified into three main categories: "On" dyskinesias, diphasic (DD), and "off" periods. The study of 168 parkinsonian patients showed that about half (n = 84) one pattern LID only. A combination two was present 68, 16 had the presentation patterns. fairly good correlation between type dyskinesia established. Chorea, myoclonus, dystonic movements occurred during "on" period. Dystonic postures, particularly affecting...
Objective Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) other prediabetic states insulin resistance could contribute to appearance sporadic AD. As such, we have assessed whether tau β‐amyloid (Aβ) deposits might be present in pancreatic tissue subjects with AD, amylin, an amyloidogenic protein deposited pancreas T2DM patients, accumulate brain AD patients. Methods We studied from 48...
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). obtain definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning relevance several clinical features APD diagnosis. In first-round, 240 neurologists Movement Disorders Group participated in study. The results obtained were incorporated into and both, questionnaire, sent out...
c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially Alzheimer's disease (AD). However, it remains unclear whether JNK or amyloid β (Aβ) appears first the onset. Postmortem brain tissues from four dementia subtypes of patients (frontotemporal dementia, Lewy body vascular and AD) were used measure activated (pJNK) Aβ levels. pJNK expression significantly increased AD; however, similar was found other dementias. Furthermore, there...
Abstract Thymidine analogs, including bromodeoxyuridine, chlorodeoxyuridine, iododeoxyuridine, and tritiated thymidine, label dividing cells by incorporating into DNA during S phase of cell division are widely employed to identify transplanted the central nervous system. However, potential for transfer thymidine analogs from grafted host has not been thoroughly tested. We here demonstrate that graft-derived can become incorporated neural precursors glia. Large numbers labeled neurons glia...
Abstract The neural mechanisms that mediate dystonia were investigated in a novel experimental primate model of dopamine agonist‐induced dystonia. This condition was produced by long‐term (15 months) agonist therapy macaque monkey had been rendered hemiparkinsonian unilateral infusion 1–methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine into the right common carotid artery. 2–deoxyglucose (2–DG) metabolic mapping technique applied to animal during expression active dystonia, and regional brain...
Thirty-eight parkinsonian patients with motor fluctuations and dyskinesias on chronic levodopa therapy were treated subcutaneous lisuride infusion (SLI). Thirty-six discharged from hospital combined treatment 24 h (111.3 +/- 29.5 micrograms/h) oral plus a decarboxylase inhibitor (729.6 452 mg/day); all obtained marked initial improvement in mobility (mean reduction 'off' hours 87.5%); 34 followed for mean of 20.85 (range 6-45) months. Most continued to show respect baseline assessment during...
ABSTRACT The objective of this study was to assess cardiovascular response during cardiac stress testing in neurologically asymptomatic individuals who developed motor features Parkinson's disease several years after the testing. This a retrospective cohort patients underwent between January 2001 and December 2010. Patients were followed until May 2012 select those disease. Heart rate blood pressure both at rest peak exercise heart variability recorded. For each patient disease, 2 matched...
Olfactory dysfunction is present in up to 90% of Alzheimer's disease (AD) patients. Although deposition hyperphosphorylated tau and β-amyloid substrates are olfactory areas, the molecular mechanisms associated with decreased smell function not completely understood. We have applied mass spectrometry-based quantitative proteomics probe additional disturbances postmortem bulbs (OB) dissected from AD cases respect neurologically intact controls (n=20, mean age 82.1 years). Relative proteome...
ProGRP (Progastrin-releasing peptide), SCC (Squamous Cell Carcinoma Antigen), and HE4 (Human epididymis protein 4) are serum tumor markers (STMs) frequently used in clinical practice, particularly for detection monitoring of ovarian lung neoplasms. In laboratories, their quantification is commonly performed using automated immunoassays. Nevertheless, variations results obtained by different immunoassays can impact diagnostic accuracy effectiveness patient monitoring. Our aim to assess...
Cynomolgus monkeys (Macaca fascicularis) were chronically treated with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) until stable parkinsonism was reached. Two months later, sacrificed and monoamine content measured in different brain regions of lesioned age-matched controls. 5-HT1A serotonin receptor density coronal sections labeled [3H]8-OH-DPAT. As expected, dopamine virtually nonexistent caudate nucleus putamen MPTP-treated monkeys. Serotonin levels...