A5082392576- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Bone health and osteoporosis research
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Bone health and treatments
- Sepsis Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Preterm Birth and Chorioamnionitis
- Pneumonia and Respiratory Infections
- Urologic and reproductive health conditions
- Ovarian cancer diagnosis and treatment
- Parathyroid Disorders and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
Universitat de Barcelona
2008-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Fundació Clínic per a la Recerca Biomèdica
2025
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2025
Hospital Clínic de Barcelona
2015-2024
Prostate Cancer UK
2024
European Association of Urology
2022
Spanish Society of Family and Community Medicine
2019-2021
Sociedad Española de Medicina Interna
2021
Clínica Rementería
2017
Spontaneous bacterial peritonitis (SBP) is associated with an important production of inflammatory mediators. However, it unknown whether there a relationship between the abdominal these mediators and development renal impairment, one most prognostic parameters in spontaneous peritonitis. We studied 52 cirrhotic patients at diagnosis resolution infection, by measuring endotoxin, tumor necrosis factor (TNF), interleukin-6 (IL-6) levels plasma ascitic fluid. Thirteen (25%) developed...
The effect of bacterial colonization the bronchi on progress airflow limitation is not well known. Therefore, pattern airway inflammation in smokers and patients with stable chronic obstructive pulmonary disease (COPD) its relation to bronchial microbial was assessed. Eight nonsmoking 18 smoking controls as 52 COPD (28 mild, 11 moderate 13 severe) were studied. All subjects investigated by means flexible bronchoscopy including protected specimen brush bronchoalveolar lavage (BAL) sampling....
The aim of our study was to analyse the serum interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) levels in patients with AS their relationship disease activity. An ELISA test used cytokine (IL-6, TNF-alpha, IL-1 IFN-gamma) 69 AS. Results were compared those from 43 RA 36 non-inflammatory back pain. between concentrations different cytokines parameters activity severity also evaluated. IL-6 TNF-alpha levels, but not...
CEA, CA 125, SCC, CYFRA 21-1 and NSE were prospectively studied in 211 patients with non-small cell lung cancer compared clinical parameters (age, sex, Karnofsky Index, symptoms smoking status), histopathological (stage, histology, tumor size nodal involvement), biological (LDH albumin) the therapy used (surgery, chemotherapy or radiotherapy). Tumor marker sensitivity was 21-1: 76%, 125: 55%, CEA: 52%, SCC: 33% NSE: 22%. One of markers abnormally high 87% locoregional disease 100%...
To evaluate the bronchial inflammatory response and its relationship to bacterial colonization in bronchiectasis, we performed a bronchoalveolar lavage (BAL) 49 patients stable clinical condition nine control subjects. BAL was processed for differential cell count, quantitative bacteriologic cultures, measurement of mediators. An increase observed percentage neutrophils (37 [0 98]) (median[range]) versus 1[0 4]%, p = 0.01), concentration elastase (90.5 [8 2,930] 34 [9 44], 0.03),...
Prognostic scales provide a useful tool to predict mortality in community-acquired pneumonia (CAP). However, the inflammatory response of host, crucial resolution and outcome, is not included prognostic scales.The aim this study was investigate whether information about initial cytokine profile markers increases accuracy 30-day mortality. To aim, prospective cohort two tertiary care hospitals designed. Procalcitonin (PCT), C-reactive protein (CRP) systemic cytokines tumour necrosis factor...
BACKGROUND Human epididymis protein 4 (HE4), a precursor of human protein, has been proposed as tumor marker for ovarian cancer. We evaluated HE4 in comparison with cancer antigen 125 (CA 125) healthy individuals and patients benign malignant diseases. METHODS CA serum concentrations were determined 101 individuals, 535 pathologies (292 gynecologic diseases) 423 diseases (127 cancers). cutoffs 35 kU/L 140 pmol/L, respectively. RESULTS results abnormal 1.1% 9.9% 12.3% 37% diseases, Renal...
<h3>Background:</h3> Lack of response to treatment in community acquired pneumonia (CAP) worsens outcome. We evaluated the systemic cytokine profile (tumour necrosis factor α, interleukin (IL)1, IL6, IL8 and IL10), C reactive protein (CRP) procalcitonin (PCT) patients with CAP who had failure. <h3>Methods:</h3> A prospective study was performed hospitalised CAP. Cytokines, PCT CRP measurements were obtained on day 1 after 72 h treatment. Treatment failure endpoint evaluated, separation those...
The aim of this study is to evaluate a new tumour marker, HE4, in comparison with CA 125 and the Risk Ovarian Malignancy Algorithm (ROMA) healthy women patients benign malignant gynaecological diseases. HE4 serum levels were determined 66 women, 285 diseases (68 endometriosis, 56 myomas, 137 ovarian cysts 24 other diseases), 33 non-active cancer 143 active (111 cancers). cut-offs 35 U/mL 150 pmol/L, respectively. ROMA algorithm cut-off was 13.1 27.7 for premenopausal or postmenopausal...
BACKGROUND MicroRNAs (miRNAs) are non-coding small RNAs, involved in post-transcriptional regulation of many target genes. METHODS Five miRNAs that have been consistently found deregulated PCa (miR-21, miR-141, miR-214, miR-375, and let-7c) were analyzed urinary pellets from 60 prostate cancer (PCa) patients 10 healthy subjects by qRT-PCR. Besides, exosomes isolated differential centrifugation for those miRNAs. RESULTS Significant upregulation miR-21, miR-375 was comparing with pellets,...
Rationale: We have previously identified six serum tumor markers (TMs) (carcinoembryonic antigen, carbohydrate antigen 15.3, squamous cell carcinoma–associated cytokeratin-19 fragment, neuron-specific enolase, and pro–gastrin-releasing peptide) related to the presence of lung cancer (LC).Objectives: To validate their individual performance in an independent cohort, explore if combined assessment (≥1 abnormal TM value) is a more accurate marker for LC presence.Methods: determined these TMs...
Kidney biomarkers appear to be useful in differential diagnosis between acute tubular necrosis (ATN) and other types of kidney injury (AKI) cirrhosis, particularly hepatorenal syndrome (HRS‐AKI). Distinction is important because treatment different. However, are still not used clinical practice. The aim the current study was investigate accuracy several AKI predicting outcome patient survival. This a prospective 320 consecutive cases patients hospitalized for decompensated cirrhosis....
A national outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 Wuhan, China, rapidly evolving to the disease (COVID-19) pandemic. Neurologic complications COVID-19 include headache, confusion, hyposmia, and dysgeusia,[1][1] with
PURPOSE: All types of trauma to the organism produce a systemic response that is proportional severity lesion caused. The more rapid clinical recovery during postoperative period patients undergoing laparoscopic-assisted colectomy vs. receiving conventional surgery suggests laparoscopic produces less surgical trauma. aim this randomized, prospective study was compare acute phase in diagnosed with colon neoplasm open segmentary colectomy. METHODS: From June 1994 July 1997 results 97 (58...
Five cases of presumed nicotine withdrawal delirium among brain-injured patients treated in a neurologic intensive care unit are presented. Each patient had history heavy tobacco use and experienced dramatic sustained clinical improvement within hours transdermal replacement. These preliminary observations suggest that may be an under-recognized cause with acute brain injury.
Objective: To assess the cytokine expression (tumor necrosis factor-α [TNF-α], interleukin [IL]-1β, and IL-6) in severe pneumonia, both locally (in lungs) systemically blood). Design: Prospective sequential study with bronchoalveolar lavage (BAL) blood sampling. Setting: Six-bed respiratory intensive care unit of a 1,000-bed teaching hospital. Patients: Thirty mechanically ventilated patients (>48 hrs) were allocated to either pneumonia group (n = 20) or control 10). Interventions: Protected...
Post-training downregulation of muscle tumour necrosis factor (TNF)‐α messenger ribonucleic acid (mRNA) expression and decrease in cellular TNF‐α levels have been reported the elderly. It is hypothesised that chronic obstructive pulmonary disease (COPD) patients may not show these adaptations due to their reduced ability increase antioxidant capacity with training. Eleven COPD (forced expiratory volume one second 40±4.4% predicted value) six age-matched controls were studied. Pre-...
Abstract Purpose: To investigate whether nuclear factor κB (NF-κB)/interleukin 6 (IL-6) was linked to docetaxel response in human prostate cancer cell lines, and inhibition of NF-κB sensitized tumor cells docetaxel. We also aimed correlate IL-6 (as a surrogate marker NF-κB) hormone-independent (HIPC) patients. Experimental Design: Hormone-dependent (LNCaP) (PC-3 DU-145) lines were exposed alone or combined with the inhibitor PS-1145 (an IκB kinase-2). Effects dose, exposure time, schedule...
To assess whether the intensity of initial systemic inflammatory response is able to predict therapy in patients with giant cell arteritis (GCA).Retrospective review 75 (49 women and 26 men) biopsy-proven GCA who had regular followup were treated according uniform criteria. Four parameters used evaluate baseline at diagnosis: fever, weight loss, erythrocyte sedimentation rate > or = 85 mm/hour, hemoglobin < 110 gm/liter. Patients considered have a weak if they 2 fewer (group 1) strong 3 4...