Isabel Graupera
A5033754624- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Acute Kidney Injury Research
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Liver physiology and pathology
- Electrolyte and hormonal disorders
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes and associated disorders
- Diet and metabolism studies
- Renal function and acid-base balance
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Nutrition and Health in Aging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatitis Viruses Studies and Epidemiology
- Cardiovascular Disease and Adiposity
- Viral gastroenteritis research and epidemiology
- Trace Elements in Health
Universitat de Barcelona
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Hospital Clínic de Barcelona
2015-2024
Centre for Biomedical Network Research on Rare Diseases
2013-2024
Harvard University
2023
Fundació Clínic per a la Recerca Biomèdica
2023
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2023
Odense University Hospital
2023
Hospital General Universitario Gregorio Marañón
2023
The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety a restrictive strategy those liberal strategy.
Background & AimsLiver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little known about prevalence general population. The aim study was to investigate adult population with unknown disease.MethodsThis a population-based, cross-sectional performed Barcelona metropolitan area. Subjects aged 18 75 years old were identified randomly from citizens included primary health care registry. Of 4866 subjects invited, 3076 participated (63.2%). Liver estimated by...
Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are 2 most popular noninvasive blood-based serum tests proposed for widespread screening. We therefore aimed to describe accuracy of FIB-4 NFS detect elevated stiffness as an indicator hepatic in low-prevalence populations.This study included a total 5129 patients with concomitant measurement FIB-4, NFS, (LSM) by Fibroscan (Echosens, France) from 5 independent population-based cohorts Spain, Hong Kong, Denmark,...
Kidney biomarkers appear to be useful in differential diagnosis between acute tubular necrosis (ATN) and other types of kidney injury (AKI) cirrhosis, particularly hepatorenal syndrome (HRS‐AKI). Distinction is important because treatment different. However, are still not used clinical practice. The aim the current study was investigate accuracy several AKI predicting outcome patient survival. This a prospective 320 consecutive cases patients hospitalized for decompensated cirrhosis....
Cirrhosis is associated with changes in gut microbiome composition. Although acute-on-chronic liver failure (ACLF) the most severe clinical stage of cirrhosis, there lack information about alterations ACLF using quantitative metagenomics. We investigated patients cirrhosis encompassing whole spectrum disease (compensated, acutely decompensated without ACLF, and ACLF). A group healthy subjects was used as control subjects.Stool samples were collected prospectively 182 cirrhosis. DNA library...
Abstract ACLF is characterized by a systemic inflammatory response, but the cytokines involved in this process have not been well studied. The aim of study was to characterize response patients with cirrhosis and its relationship prognosis. Fifty-five cirrhosis, 26 ACLF, were studied prospectively. Systemic analyzed measuring large array plasma using multiplex kit. A principal component analysis show noticeable differences between decompensated without ACLF. Patients had significant abnormal...
Background Biomarkers are potentially useful in assessment of outcomes patients with cirrhosis, but information is very limited. Given the large number biomarkers, adequate choice which biomarker(s) to investigate first important. Aim Analysis potential usefulness a panel urinary biomarkers outcome cirrhosis. Patients and Methods Fifty-five acute decompensation cirrhosis were studied: 39 had Acute Kidney Injury (AKI) (Prerenal 12, type-1 HRS (hepatorenal syndrome) 15 Tubular Necrosis (ATN)...
<h3>Objective</h3> MicroRNAs (miRNAs) are well-known regulators of disease pathogenesis and have great potential as biomarkers therapeutic targets. We aimed at profiling miRNAs in alcoholic hepatitis (AH) identifying potentially involved liver injury. <h3>Design</h3> MiRNA was performed samples from patients with AH, alcohol disease, non-alcoholic steatohepatitis, HCV normal tissue. Expression assessed serum AH animal models. Mimic decoy miR-182 were used vitro vivo to evaluate miR-1829s...