A5102849627- Clinical Laboratory Practices and Quality Control
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Infant Nutrition and Health
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Biochemical Analysis and Sensing Techniques
- Dialysis and Renal Disease Management
- Pneumonia and Respiratory Infections
- Blood Coagulation and Thrombosis Mechanisms
- Central Venous Catheters and Hemodialysis
- Helicobacter pylori-related gastroenterology studies
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Tendon Structure and Treatment
- Healthcare cost, quality, practices
- Shoulder Injury and Treatment
- Complement system in diseases
- Colorectal Cancer Surgical Treatments
- Neonatal Health and Biochemistry
- Venous Thromboembolism Diagnosis and Management
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Ginger and Zingiberaceae research
Odense University Hospital
1997-2024
Svendborg Sygehus
2013-2024
University of Southern Denmark
2016-2021
Creative Commons
2017
Aarhus University Hospital
2009-2013
Dansk Sygehus Institut
1998
Vejle Sygehus
1995
Statens Serum Institut
1992
Rigshospitalet
1992
Herlev Hospital
1992
•462 patients with compensated ALD experienced 84 liver-related events during a median of 4.1 years follow-up, and 76 died.•Elastography the ELF test are accurate prognostic tests outperform biopsy-verified fibrosis stage.•3-5% F0-1, liver stiffness by FibroScan <10 kPa, or <9.8 follow up.•This increased to 53–64% F3-4, >15 >10.5.•The hazard ratio for was 8 10-15 28 kPa. Background & AimsAlcohol is most common cause mortality morbidity. We therefore aimed assess compare performance...
Abstract Background The relationship between therapeutic delay and long-term survival from colorectal cancer is unclear. This association was examined prospectively among patients with in Denmark. Methods A total of 740 were included a prospective, population-based study three Danish counties 1 January 2001 to 31 July 2002. Delay determined by self-report during standardized interview. Cox proportional hazards regression used compute the hazard ratio (HR) associated delay, while adjusting...
To determine when a change in serial measurements of prothrombin time patients receiving oral anticoagulant therapy (ACT) is statistically significant biological necessitating dose adjustment, one must know the size "critical difference" statistical terms (i.e., probabilities). In cohort 32 ACT at pharmacological steady-state, we studied within-subject total variation time, expressed as International Normalized Ratio (INR), over 6 months. The (CV) INR was 10.1%. corresponding critical...
Despite careful monitoring of oral anticoagulant treatment (OAT), some international normalized ratio (INR) for prothrombin time values will fall outside the therapeutic range. Considerable changes in serial INR results from OAT patients may be caused by random fluctuation alone, and, statistical reasons, a fraction range and interfere with dose adjustments. On basis intervals evaluation reference changes, we suggest discuss an alternative method interpretation measurements. Retrospective...
Complement activation and neutrophil degranulation were concomitantly studied during uncomplicated cardiopulmonary bypass (CPB). Plasma concentrations of complement factor C4, split product C3d, the lysosomal enzyme elastase complexed with α1-proteinase inhibitor (PI) fibronectin measured in 12 patients. C3d elastase/PI increased significantly CPB (volume-corrected results). The rise was almost linear, whereas showed exponential increase. Mean mean at different times covaried closely. study...
Several investigators have observed a relationship between the sex hormones and peptic ulcer. Borri (1904) claimed to frequently seen aggravation of ulcer in women at onset menopause. This observation has since been confirmed by many other workers. (For references vide Sandweiss, 1939, Clark, 1953). The ratio male female patients with is 80–90/10–20 for adults 52/49 children. Pregnancy causes improvement condition about 90 per cent (Clark, Numerous attempts made treat hormones, among others...
Abstract Alcohol‐associated liver fibrosis accumulates over decades, driven by hepatic inflammation and cell death. We investigated the diagnostic accuracy of keratin‐18 degradation, measured using serum M30 M65 levels, ActiTest for inflammatory activity in patients with compensated alcohol‐associated disease (ALD). Furthermore, we evaluated prognostic markers liver‐related events all‐cause mortality. All findings were compared routine function tests: Aspartate aminotransferase (AST),...
Very different concentrations of plasma-lactoferrin in healthy adults have been reported the literature. We compared three commercially available lactofer-rins and lactoferrin purified our laboratory as calibrators an ELISA. No statistical differences among these preparations were detected. The concentration was measured by dry weight, efforts made order to minimize loss adhesion tubes etc. thus, secure accuracy method. Dilutions PBS 0.01 moll-1 with NaCl 0.436moll-1, (NH4)2SO4 0.5moll-1,...
Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess role UA in disease, we investigated levels both healthy asymptomatic middle-aged individuals different subgroups hospitalized patients suspected or definite myocardial infarction (MI).The calcification (CAC) was examined (n=1039) using a noncontrast computed tomography scan. Hospitalized acute MI (n=772) were grouped according to troponin I (TnI) concentrations: (i) elevated TnI...
Abstract The binding of immune complexes (1C) to polymorphonuclear leukocytes (PMN) and the consequent respiratory burst (RB) were investigated in whole blood cell preparations suspended 75% human serum, using flow cytometry. Blockade complement receptor (CR)1 sites for C3b on cells monoclonal antibody (mAb) 3D9 resulted a 1.9‐fold increase IC‐elicited PMN RB after 5 min incubation, rising 3.1‐fold 40 min. This enhancement was not due increased IC deposition PMN. CR3 abrogated mAb...
The concentration of leukocytes and the fraction neutrophil granulocytes are two important criteria in diagnosis peritonitis continuous ambulatory peritoneal dialysis (CAPD). We have found that unstable effluents, resulting false low leukocyte concentrations if not counted immediately. At 25 degrees C count decreases 25%-30% 4-6 hours. Sampling tubes containing EDTA storage at 4 make stable for 6 hours, while combination ensures stability 24 When samples handled accordingly, as high 2 x...
Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and a guide treatment decision.The aim this study was the impact lower reporting limit for C-reactive protein (CRP), with respect intraindividual biological variability, on calculation DAS28 subsequent patient classification.This consists 2 sections: theoretical consideration discussing performance CRP calculating taking variation into account cross-sectional RA patients...
Falcarinol is a polyacetylene which found in carrots and known to have anti-neoplastic properties rodents. Research the bioactivity of falcarinol humans require methods for quantification human serum. Here we report development an LC-MS/MS method its use measure serum concentrations following intake carrot product. was measured by using m/z 268 182 mass transition. Six calibrator levels (0.2-20 ng/mL) 3 control (0.4, 2 8 were prepared addition pools. Linearity developed good with mean R2...
An Elisa for neutrophil elastase (ELA) in complex with ax-protease inhibitor (PI) (α1 -antitrypsin) was developed microtitre plates and compared to the ELISA kit from MERCK (2-h version). Recovery of ELA-PI good both assays. The detection limits were 4.4μg1-1 7.7μg1-1 in-house assay, respectively, while quantitation estimated (5.5-9.9 μg1-1) 28.9 μg1-1 (14.6-44.3 two Furthermore, as dilution curves normal plasma parallel calibration curve assay over a wide range dilutions, it is feasible...