A5033050463- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Cystic Fibrosis Research Advances
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- High Altitude and Hypoxia
- Inhalation and Respiratory Drug Delivery
- Delphi Technique in Research
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Obstructive Sleep Apnea Research
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Universitat Pompeu Fabra
2016-2025
Hospital Del Mar
2016-2025
Barcelona Biomedical Research Park
2016-2025
Municipal Institute for Medical Research
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Instituto de Salud Carlos III
2016-2025
Parc de Salut
2016-2025
Centro de Investigación Biomédica en Red
2008-2024
Central University Hospital of Asturias
2024
Centre for Biomedical Network Research on Rare Diseases
2018-2023
Key Principle #1: Causal inference requires careful consideration of confounding d Preferred variable selection methods 1. Historical confounder definition with purposeful 2. models using directed acyclic graphs Variable that do not adequately control for 3. P value-or model-based 4. Methods based on b-coefficient changes 5. Selection variables to identify "independent predictors" Do present all the effect estimates from a model designed test single causal association (Table 2 fallacy) #2:...
Inflammation and oxidative stress contribute to muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). Oxidants contained cigarette smoke (CS) induce adverse effects on tissues through phenomena.To explore inflammation quadriceps of human smokers diaphragm limb muscles guinea pigs chronically exposed CS.Muscle function, protein oxidation nitration, antioxidants, oxidized proteins, inflammation, creatine kinase activity, lung structures were investigated vastus...
Skeletal muscle dysfunction occurs in patients with chronic obstructive pulmonary disease (COPD) and affects both ventilatory nonventilatory groups. It represents a very important comorbidity that is associated poor quality of life reduced survival. results from complex combination functional, metabolic, anatomical alterations leading to suboptimal work. Muscle atrophy, altered fiber type metabolism, chest wall remodeling, the case respiratory muscles, are relevant etiological contributors...
Prediction models aim to use available data predict a health state or outcome that has not yet been observed. is primarily relevant clinical practice, but also used in research, and administration. While prediction modeling involves estimating the relationship between patient factors outcomes, it distinct from casual inference. thus requires unique considerations for development, validation, updating. This document represents an effort editors at 31 respiratory, sleep, critical care medicine...
The present study was aimed at evaluating the effects of a specific inspiratory muscle training protocol on structure muscles in patients with chronic obstructive pulmonary disease. Fourteen (males, FEV1, 24 ± 7% predicted) were randomized to either or sham groups. Supervised breathing using threshold device performed 30 minutes per day, five times week, for 5 consecutive weeks. group subjected loading equivalent 40 50% their maximal pressure. Biopsies from external intercostal and vastus...
CEA, CA 125, SCC, CYFRA 21-1 and NSE were prospectively studied in 211 patients with non-small cell lung cancer compared clinical parameters (age, sex, Karnofsky Index, symptoms smoking status), histopathological (stage, histology, tumor size nodal involvement), biological (LDH albumin) the therapy used (surgery, chemotherapy or radiotherapy). Tumor marker sensitivity was 21-1: 76%, 125: 55%, CEA: 52%, SCC: 33% NSE: 22%. One of markers abnormally high 87% locoregional disease 100%...
Oxidative stress is involved in the skeletal muscle dysfunction observed patients with severe chronic obstructive pulmonary disease (COPD). We hypothesized that diaphragms of such might generate greater levels oxidants than those neutralized by antioxidants.To assess both oxidative and nitrosative different antioxidants patients, to analyze potential relationships lung respiratory dysfunctions.We conducted a case-control study which reactive carbonyl groups, hydroxynonenal-protein adducts,...
The molecular sources of reactive oxygen species (ROS) in skeletal muscles are not well understood. We hypothesized that nonphagocyte NAD(P)H oxidase could be a source ROS muscle fibers. thus investigated the existence, structure, and contribution to production rat muscles. activity were evaluated by lucigenin-enhanced chemiluminescence NADH consumption rate, whereas enzyme composition was monitored reverse transcription-polymerase chain reaction immunoblotting. Basal O2 − strips from normal...
<h3>Background:</h3> Systemic proinflammatory cytokines and oxidative stress have been described in association with peripheral muscle wasting weakness of patients severe chronic obstructive pulmonary disease (COPD), but their expression skeletal is unknown. The objectives the present study were to determine protein levels selected COPD relationships carbonylation as a marker stress, quadriceps function exercise capacity. <h3>Methods:</h3> We conducted cross sectional which 36 detected using...
Oxidative stress may differentially regulate protein loss within peripheral muscles of severe chronic obstructive pulmonary disease (COPD) patients exhibiting different body composition. Oxidation levels proteins, myosin heavy chain (MyHC) and myonuclei, superoxide anion, antioxidants, actin, creatine kinase, carbonic anhydrase-3, ubiquitin–proteasome system, redox-signalling pathways, inflammation muscle structure, damage were quantified in limb COPD with without wasting, sedentary...
Being well-established in advanced chronic obstructive pulmonary disease (COPD), skeletal muscle dysfunction and its underlying pathology have been scarcely investigated patients with mild-to-moderate airflow obstruction. We hypothesized that a loss of oxidative phenotype (oxphen) associated decreased endurance is present the COPD. In quadriceps biopsies from 29 COPD (forced expiratory volume 1 s [FEV1] 58 ± 16%pred, body mass index [BMI] 26 4 kg/m(2)) 15 controls (BMI 25 3 we assessed fiber...
Lung resection surgery further decreases exercise capacity and negatively affects respiratory muscle function in patients with non-small cell lung cancer (NSCLC). The best design for interventions these has not been determined yet.To assess the impact of aerobic high-intensity training on patient outcomes following surgery.Prospective, single-blind, pilot randomized controlled trial.Outpatient cardiopulmonary rehabilitation unit two university hospitals.Thirty-seven NSCLC after tumor...
There is little information available concerning the extent to which chronic obstructive pulmonarv disease (COPD) patients are satisfactorily managed, especially, regards factors supposedly related COPD exacerbation. The present study assessed prevalence rates of potentially modifiable risk exacerbation in hospitalized for this reason. A systematic sample one out two admitted exacerbation, during 1 yr, four tertiary hospitals Barcelona area, Spain, was performed. Patients answered a...
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<h3>Background:</h3> Although exercise training has beneficial effects on skeletal muscle bioenergetics and performance in patients with severe chronic obstructive pulmonary disease (COPD), it may also be associated increased quadriceps oxidative nitrosative stress. The aim of this study was to explore stress COPD, both before after a 3 week endurance programme, identify the nature oxidatively modified proteins. <h3>Methods:</h3> Reactive carbonyls, hydroxynonenal–protein adducts,...
Reactive oxygen and nitrogen species (ROS RNS) have been proposed as mechanisms of cancer-induced cachexia. In this study, we assessed using Western blot analysis the levels total protein carbonylation (2,4-dinitrophenylhydrazine assay), both malondialdehyde- (MDA-) 2-hydroxy-4-nonenal- (HNE-) adducts, Mn-superoxide dismutase (Mn-SOD), catalase, heme oxygenase-1 (HO-1) 3-nitrotyrosine formation in gastrocnemius muscles rats bearing Yoshida AH-130 hepatoma. tumour-bearing animals, measured by...