A5059937177- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Noise Effects and Management
- Climate Change and Health Impacts
- Asthma and respiratory diseases
- Air Quality Monitoring and Forecasting
- COVID-19 and Mental Health
- Health disparities and outcomes
- SARS-CoV-2 and COVID-19 Research
- Vehicle emissions and performance
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Occupational and environmental lung diseases
- Urban Green Space and Health
- Vaccine Coverage and Hesitancy
- Cancer-related molecular mechanisms research
- Physical Activity and Health
- Occupational exposure and asthma
- Genetic Associations and Epidemiology
- COVID-19 Digital Contact Tracing
- Pulmonary Hypertension Research and Treatments
- Misinformation and Its Impacts
- Korean Urban and Social Studies
- COVID-19 and healthcare impacts
University of Basel
2015-2024
Swiss Tropical and Public Health Institute
2015-2024
Swiss School of Public Health
2023
Service de la Santé Publique
2023
University of Bern
2023
Society of Thoracic Surgeons
2015
Institute of Social and Preventive Medicine
2006-2009
University of Washington
2006
Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure participants of cohort studies. Within the ESCAPE project, PM(2.5), PM(2.5) absorbance, PM(10), PM(coarse) were measured 20 European study areas at sites per area. GIS-derived predictor variables (e.g., traffic intensity, population, land-use) evaluated to model annual average each The median explained variance (R(2)) was...
Air pollution has been associated with impaired health, including reduced lung function in adults. Moving to cleaner areas shown attenuate adverse effects of air on children but not adults.We conducted a prospective study 9651 adults (18 60 years age) randomly selected from population registries 1990 and assessed 1991, 8047 participants reassessed 2002. There was complete information volumes flows (e.g., forced vital capacity [FVC], expiratory volume 1 second [FEV1], FEV1 as percentage FVC,...
There is some evidence for an association between traffic noise and ischemic heart disease; however, associations with blood pressure have been inconsistent, little known about health effects of railway noise.We aimed to investigate the exposure on pressure; a secondary aim was address potentially susceptible subpopulations.We performed adjusted linear regression analyses using data from 6,450 participants second survey Swiss Study Air Pollution Lung Disease in Adults (SAPALDIA 2) estimate...
Rationale: There is limited evidence from population-based studies demonstrating incidence of spirometric-defined chronic obstructive pulmonary disease (COPD) in association with occupational exposures.Objectives: We evaluated the between exposures and COPD Swiss Cohort Study on Air Pollution Lung Heart Diseases Adults (SAPALDIA).Measurements Main Results: Prebronchodilator ratio forced expiratory volume 1 second over vital capacity (FEV1/FVC) was measured 4,267 nonasthmatic SAPALDIA...
<h3>Abstract</h3> Recurrent cortical network dynamics plays a crucial role for sequential information processing in the brain. While theoretical framework of reservoir computing provides conceptual basis understanding recurrent neural computation, it often requires manual adjustments global parameters, particular spectral radius synaptic weight matrix. Being mathematical and relatively complex quantity, is not readily accessible to biological networks, which generally adhere principle that...
Land Use Regression (LUR) is a popular method to explain and predict spatial contrasts in air pollution concentrations, but LUR models for ultrafine particles, such as particle number concentration (PNC) are especially scarce. Moreover, no have been previously presented the lung deposited surface area (LDSA) of particles. The additional value metrics has not well investigated due lack exposure measurements models.Air were performed 2011 2012 eight areas Swiss SAPALDIA study at up 40 sites...
The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), conducted 1991 (SAPALDIA 1) eight areas among 9,651 randomly selected adults aged 18-60 years, reported associations the prevalence of respiratory symptoms, nitrogen dioxide, particles with an aerodynamic diameter less than 10 microg/m3. Later, 8,047 subjects reenrolled 2002 2). effects individually assigned traffic exposures symptoms were estimated, while controlling for socioeconomic exposure- health-related...
Reductions in mortality following improvements air quality were documented by several studies, and our group found, an earlier analysis, that decreasing particulate levels attenuate lung function decline adults.We investigated whether decreases particulates with aerodynamic diameter of less than 10 microm (PM10) associated lower rates reporting respiratory symptoms (i.e., decreased morbidity) on follow-up.The present analysis includes 7,019 subjects who underwent detailed baseline...
Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources remains unclear.We investigated association PM10 (≤ 10 μm), PM2.5 2.5 μm: total mass, vehicular, crustal sources), ultrafine particles [UFP < 0.1 number concentration (PNC) lung-deposited surface area (LDSA)] carotid intima-media thickness (CIMT).We used data from 1,503 participants ≥ 50 years old who participated in third examination Swiss...
The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine what extent restriction impaired quality of life. used data from two large population-based European cohorts: 6698 Community Respiratory Health Survey (ECRHS) 6069 Swiss Cohort Study on Air Pollution Lung Heart Diseases in Adults (SAPALDIA) adult participants. was defined as forced expiratory volume 1 s (FEV )/forced vital capacity (FVC) ≥lower limit normal (LLN) FVC...
Although the dispersion model approach has been used in some epidemiologic studies to examine health effects of traffic-specific air pollution, no study evaluated predictions vigorously.We total and particulate matter < 10 2.5 microm aero-dynamic diameter (PM(10), PM(2.5)), nitrogren dioxide, nitrogen oxide concentrations predicted by Gaussian models against fixed-site measurements at different locations, including traffic-impacted, urban-background, alpine settings between across cities....
Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes decrease in lung function. Socioeconomic status (SES) known to be associated with both exposure respiratory This study assesses the role SES either as confounder or effect modifier association between ambient Cross-sectional data from three European multicenter adult cohorts were pooled assess factors function, including annual means home outdoor NO2. Pre-bronchodilator...
Objectives: To describe the rationale, organization, and procedures of Corona Immunitas Digital Follow-Up (CI-DFU) eCohort to characterize participants at baseline. Methods: Participants Immunitas, a population-based nationwide SARS-CoV-2 seroprevalence study in Switzerland, were invited join CI-DFU 11 centres. Weekly online questonnaires cover health status changes, prevention measures adherence, social impacts. Monthly questionnaires additional contact tracing apps use, vaccination vaccine...
Abstract Background Seroprevalence and the proportion of people with neutralizing activity (functional immunity) against SARS-CoV-2 variants were high in early 2022. In this prospective, population- based, multi-region cohort study, we assessed development functional hybrid immunity (induced by vaccination infection) general population during period incidence infections Omicron variants. Methods We randomly selected individuals aged ≥16 years from southern (n = 739) north-eastern 964)...
A higher incidence of asthma is reported in women compared with men, but evidence later adulthood limited. We aimed to determine the 20-year cumulative adult Switzerland and its relation sex, taking into account age allergic sensitisation. assessed self-report doctor-diagnosed between 1991/1992 2010/2011 5128 subjects without asthma, aged 18–60 years at baseline. The age-related probability onset was analysed by logistic regression adjusting for potential confounders stratified sex...
Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding the benefits residential greenness. To identify in immediate surroundings residence. We analyzed genome-wide 1938 blood samples (982 participants) from Swiss Cohort Study on Air Pollution and Lung Heart Diseases Adults (SAPALDIA). estimated based normalized difference vegetation...