Francesco Pennacchio
A5090308781- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Long-Term Effects of COVID-19
- Gold and Silver Nanoparticles Synthesis and Applications
- COVID-19 Impact on Reproduction
- Quantum Dots Synthesis And Properties
- Advanced Electron Microscopy Techniques and Applications
- Respiratory viral infections research
- Family Support in Illness
- Health disparities and outcomes
- Nanocluster Synthesis and Applications
- Childhood Cancer Survivors' Quality of Life
- Spectroscopy and Quantum Chemical Studies
- Misinformation and Its Impacts
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Condensed Matter Physics
- Mental Health Treatment and Access
- Magnetic Properties and Synthesis of Ferrites
- Viral Infections and Outbreaks Research
- Iron oxide chemistry and applications
- Dermatology and Skin Diseases
University Hospital of Geneva
2020-2023
Primary Health Care
2022
Geneva College
2022
École Polytechnique Fédérale de Lausanne
2016-2019
University of Zurich
2019
University of Colorado Boulder
2017
Abstract Understanding the risk of infection from household- and community-exposures transmissibility asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence based primarily on virologic testing, which disproportionately misses mild infections. Serologic measures are more likely capture all previously infected individuals. We apply household transmission models data a cross-sectional, household-based population serosurvey 4,534 people ≥5 years 2,267 households...
Abstract Background Serological assays detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are being widely deployed in studies and clinical practice. However, the duration effectiveness of protection conferred by immune response remains to be assessed population-based samples. To estimate incidence newly acquired SARS-CoV-2 infections seropositive individuals as compared seronegative controls, we conducted a retrospective longitudinal matched study....
More than two years into the COVID-19 pandemic, most of population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making is hindered by lack up-to-date and precise characterization immune landscape in population. Here, we estimated seroprevalence cross-variant neutralization capacity after Omicron became dominant Geneva, Switzerland.We conducted a population-based serosurvey between April 29 June 9, 2022, recruiting children adults...
The medium-term impact of the COVID-19 pandemic on wellbeing children and adolescents remains unclear. More than 2 years into pandemic, we aimed to quantify frequency determinants having been severely impacted by estimate its health-related quality life (HRQoL) mental health.
Background Up-to-date seroprevalence estimates are critical to describe the SARS-CoV-2 immune landscape and guide public health decisions. Aim We estimate of anti-SARS-CoV-2 antibodies 15 months into COVID-19 pandemic 6 vaccination campaign. Methods conducted a population-based cross-sectional serosurvey between 1 June 7 July 2021, recruiting participants from age- sex-stratified random samples general population. tested for targeting spike (S) or nucleocapsid (N) proteins using Roche...
Abstract Limited data exist on SARS-CoV-2 infection rates across sectors and occupations, hindering our ability to make rational policy, including vaccination prioritization, protect workers limit spread. Here, we present results from SEROCoV-WORK + study, a serosurvey of recruited after the first wave COVID-19 pandemic in Geneva, Switzerland. We tested (May 18—September 18, 2020) 16 32 occupations for anti-SARS-CoV-2 IgG antibodies. Of 10,513 participants, 1026 (9.8%) positive. The...
Aims: To assess SARS-CoV-2 seroprevalence over the first epidemic wave in canton of Geneva, Switzerland, as well risk factors for infection and symptoms associated with IgG seropositivity. Methods: Between April June 2020, former participants a representative survey 20–74-year-old population Geneva were invited to participate study, along household members aged 5 years. Blood samples tested anti-SARS-CoV-2 immunoglobulin G. Questionnaires self-administered. We estimated Bayesian model...
Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection infection with pre-Omicron lineages. This has been challenged by the emergence immune-evasive variants, notably Omicron sublineages, in an evolving immune landscape high cumulative incidence and vaccination coverage. turn limits use widely available commercial high-throughput methods quantify binding antibodies as a tool monitor at population-level. Here we show that anti-Spike RBD levels, quantified...
In metal nanoparticles (NPs) supracrystals, the metallic core provides some key properties, e.g. magnetization, plasmonic response or conductivity, with ligand molecules giving rise to others like solubility, assembly interaction biomolecules. The formation of these supracrystals depends on a complex interplay between many forces, stemming from core, ligands. At present, there is no known approach characterize local order their dynamics atomic spatial resolution. Here, we develop methodology...
Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence risk factors of pediatric post-COVID a population-based sample, stratifying by serological status. Children from SEROCoV-KIDS cohort study (State Geneva, Switzerland), aged 6 months 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) parents filled questionnaire on persistent symptoms their (lasting over 12 weeks) compatible with post-COVID. Of...
Objectives: To describe the rationale, organization, and procedures of Corona Immunitas Digital Follow-Up (CI-DFU) eCohort to characterize participants at baseline. Methods: Participants Immunitas, a population-based nationwide SARS-CoV-2 seroprevalence study in Switzerland, were invited join CI-DFU 11 centres. Weekly online questonnaires cover health status changes, prevention measures adherence, social impacts. Monthly questionnaires additional contact tracing apps use, vaccination vaccine...
There are concerns about acute and long-term mental health effects of the COVID-19 pandemic. This study examined prevalence predictors psychological distress before, during, after a pandemic wave in Switzerland, 2021. Prevalence was estimated adults aged 35-96 years using General Health Questionnaire-12 administered June 2021 (Specchio-COVID19 cohort, N = 3965), compared to values from 2003 2006 (CoLaus|PsyCoLaus 5667). Anxiety depression were assessed February Generalised Disorder scale-2...
Children and adolescents are highly vulnerable to the impact of sustained stressors during developmentally sensitive times. We investigated how demographic characteristics intersect with socioeconomic dimensions shape social patterning quality life mental health in children adolescents, two years into COVID-19 pandemic.We used data from prospective SEROCoV-KIDS cohort study living Geneva (Switzerland, 2022). conducted an intersectional Multilevel Analysis Individual Heterogeneity...
Abstract Background Population-based serological surveys provide a means for assessing the immunologic landscape of community, without biases related to health-seeking behaviors and testing practices typically associated with rt-PCR testing. This study assesses SARS-CoV-2 seroprevalence over first epidemic wave in Canton Geneva, Switzerland, as well biological socio-economic risk factors infection symptoms IgG seropositivity. Methods findings Between April 6 June 30, 2020, former...
This study aimed to assess acceptance of COVID-19 vaccination as well its sociodemographic and clinical determinants, 3 months after the launch programme in Geneva, Switzerland.In March 2021, an online questionnaire was proposed adults included a longitudinal cohort previous SARS-CoV-2 serosurveys carried out canton which former participants population-based health survey individuals randomly sampled from population registries, their household members. Questions were asked about acceptance,...
Background: More than two years into the COVID-19 pandemic, it is generally assumed that most of population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making hindered by lack up-to-date and precise characterization immune landscape in population. We thus aimed to estimate seroprevalence cross-variant neutralization capacity after Omicron became dominant Geneva, Switzerland. Methods: conducted a population-based serosurvey...
We present inelastic neutron scattering data across the Verwey transition in magnetite, obtained for a single crystal via detwinning method. provide direct evidence of influence charge order on transverse-acoustic phonons, associated with discontinuous hardening and narrowing at temperature, energy splitting different polarizations. This contrasts behavior transverse-optical X3 mode, which does not any critical anomaly, contrary to theoretical expectations. Our indicate that incommensurate...
Objectives To report a prospective epidemiological, virological and serological investigation of SARS-CoV-2 outbreak in primary school. Methods As part longitudinal, prospective, school-based surveillance study, this involved repeated testing 73 pupils, 9 teachers, 13 non-teaching staff 26 household members participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0–2 Day 5–7), serologies on dried capillary blood samples 30), contact tracing interviews whole genome...
Background SARS-CoV-2 infection and its health consequences have disproportionally affected disadvantaged socio-economic groups globally. This study aimed to analyze the association between conditions having developed antibodies for-SARS-CoV-2 in a population-based sample canton of Geneva, Switzerland. Methods Data was obtained from serosurvey adults Geneva their household members, November December, 2020, toward end second pandemic wave canton. Participants were tested for for-SARS-CoV-2....
We aimed to examine factors associated with parental willingness vaccinate their children against COVID-19.We surveyed adults included in a digital longitudinal cohort study composed of participants previous SARS-CoV-2 serosurveys conducted Geneva, Switzerland. In February 2022, an online questionnaire collected information on COVID-19 vaccination acceptance, aged ≥5 years and reasons for preference. used multivariable logistic regression assess the demographic, socioeconomic health-related...
This study aimed to assess the public perception of COVID-19 vaccination certificates as well potential differences between individuals.Between 17 March and 1 April 2021, a self-administered online questionnaire was proposed all persons aged 18 years older participating in longitudinal follow-up SARS-CoV-2 seroprevalence studies Geneva, Switzerland. The covered aspects individual collective benefits, allowed participants select contexts which should be presented. Results were presented...
Ultrafast electron diffraction is a powerful technique to investigate out-of-equilibrium atomic dynamics in solids with high temporal resolution. When performed reflection geometry, the main limitation mismatch group velocity between overlapping pump light and probe pulses, which affects overall resolution of experiment. A solution already available literature involved pulse front tilt beam at sample, providing sub-picosecond time However, reported optical scheme, tilted characterized by...
Serosurveys are an important tool to estimate the true extent of current SARS-CoV-2 pandemic. So far, most serosurvey data have been analyzed with cutoff-based methods, which dichotomize individual measurements into sero-positives or negatives based on a predefined cutoff. However, mixture model methods can gain additional information from same data. Such refrain dichotomizing values and instead use full distribution serological pre-pandemic COVID-19 controls cumulative incidence. This study...