María-Eugenia Zaballa
A5058937936- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Childhood Cancer Survivors' Quality of Life
- Infection Control and Ventilation
- Health disparities and outcomes
- Vaccine Coverage and Hesitancy
- Adolescent and Pediatric Healthcare
- Magnetism in coordination complexes
- Family Support in Illness
- COVID-19 and healthcare impacts
- Metal-Catalyzed Oxygenation Mechanisms
- Mitochondrial Function and Pathology
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Photosynthetic Processes and Mechanisms
- Crystallography and molecular interactions
- Respiratory viral infections research
- Acne and Rosacea Treatments and Effects
- ATP Synthase and ATPases Research
- Peroxisome Proliferator-Activated Receptors
- Youth Substance Use and School Attendance
University Hospital of Geneva
2021-2025
École Polytechnique Fédérale de Lausanne
2015-2018
Instituto de Biología Molecular y Celular de Rosario
2010-2013
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2013
National University of Rosario
2010-2013
University at Buffalo, State University of New York
2010
The reversible modification of cysteine residues by thioester formation with palmitate (S-palmitoylation) is an abundant lipid post-translational (PTM) in mammalian systems. S-palmitoylation has been observed on mitochondrial proteins, providing intriguing potential connection between metabolic lipids and regulation. However, it unknown whether and/or how regulated. Here we report the development mitoDPPs, targeted fluorescent probes that measure activity levels "erasers" S-palmitoylation,...
The medium-term impact of the COVID-19 pandemic on wellbeing children and adolescents remains unclear. More than 2 years into pandemic, we aimed to quantify frequency determinants having been severely impacted by estimate its health-related quality life (HRQoL) mental health.
Abstract Limited data exist on SARS-CoV-2 infection rates across sectors and occupations, hindering our ability to make rational policy, including vaccination prioritization, protect workers limit spread. Here, we present results from SEROCoV-WORK + study, a serosurvey of recruited after the first wave COVID-19 pandemic in Geneva, Switzerland. We tested (May 18—September 18, 2020) 16 32 occupations for anti-SARS-CoV-2 IgG antibodies. Of 10,513 participants, 1026 (9.8%) positive. The...
Protein-mediated electron transfer is an essential event in many biochemical processes. Efficient requires the reorganization energy of redox to be minimized, which ensured by presence rigid donor and acceptor sites. Electron copper sites are present ubiquitous cupredoxin fold, able bind one or two ions. The low these metal centers has been accounted for assuming that protein scaffold creates entatic/rack-induced state, gives rise a environment means preformed chelating site. However, this...
Introduction The COVID-19 pandemic has affected billions of people around the world both directly through infection itself and indirectly its economic, social sanitary impact. Collecting data over time is essential for understanding disease spread, incidence COVID-19-like symptoms, level dynamics immunity, as well long-term impact pandemic. objective study was to set up a longitudinal follow-up adult participants serosurveys carried out in canton Geneva, Switzerland, during This aims at...
Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection infection with pre-Omicron lineages. This has been challenged by the emergence immune-evasive variants, notably Omicron sublineages, in an evolving immune landscape high cumulative incidence and vaccination coverage. turn limits use widely available commercial high-throughput methods quantify binding antibodies as a tool monitor at population-level. Here we show that anti-Spike RBD levels, quantified...
Objectives This study aims (1) to assess the prevalence of severe fatigue among general population Geneva, 2 years into COVID-19 pandemic and (2) identify non-pandemic factors associated with fatigue. Design Cross-sectional population-based survey conducted in Spring 2022. Setting General adult Switzerland. Participants 6870 participants, randomly selected from population, included Specchio-COVID-19 cohort study, were invited answer an online health survey. Outcome cofactor measure...
The COVID-19 pandemic, starting in 2020, raised concerns about potential long-term health impacts, including its effects on cardiovascular and related biomarkers. This study part of the Bus Santé Geneva, Switzerland, compared metabolic profiles pre- (2016-2019) post-pandemic (2023-2024) among individuals aged 30-75. Participants completed questionnaires underwent a clinical visit, physical examination fasting blood test to assess lipid glycemic profiles. Linear regression was used estimate...
The COVID-19 pandemic prompted significant shifts to teleworking, raising questions about potential impacts on employee wellbeing. This study examined the association between self-reported changes teleworking frequency (relative before pandemic) and two indicators of occupational burnout: emotional exhaustion professionally diagnosed burnout. Data were derived from samples a digital cohort based in Geneva, Switzerland: one population-based, sample workers who likely mobilized early stages...
To examine the physical, psychological, and social well-being of children with without special healthcare needs after pandemic-related restrictions were lifted. Drawing on three-wave data from SEROCoV-KIDS prospective, population-based cohort, we performed an outcome-wide, longitudinal analysis to investigate association (none, moderate, or complex needs) at Time 1 (September 2022 through February 2023) (15 outcomes) 2 (May September 2023), adjusting for characteristics prior outcome values...
Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence risk factors of pediatric post-COVID a population-based sample, stratifying by serological status. Children from SEROCoV-KIDS cohort study (State Geneva, Switzerland), aged 6 months 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) parents filled questionnaire on persistent symptoms their (lasting over 12 weeks) compatible with post-COVID. Of...
Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found ET sites in proteins also can be constructed without ligation (called "type zero" sites). Here report multifrequency paramagnetic resonance (EPR), magnetic circular dichroism (MCD), nuclear (NMR) spectroscopic data together with density functional theory (DFT) spectroscopy-oriented configuration interaction (SORCI)...
In the 5th year after emergence of SARS-CoV-2, Omicron lineages continue to evolve and cause infections. Here, we used eight authentic SARS-CoV-2 isolates assess their capacity escape immunity different exposure histories replicative in polarized human airway epithelial cells (HAE) derived from nasal bronchial epithelium. Using live-virus neutralization assays 108 sera or plasma immunological backgrounds, progressive immune was observed B.1 (ancestral virus) EG.5.1, but no significant...
Children and adolescents are highly vulnerable to the impact of sustained stressors during developmentally sensitive times. We investigated how demographic characteristics intersect with socioeconomic dimensions shape social patterning quality life mental health in children adolescents, two years into COVID-19 pandemic.We used data from prospective SEROCoV-KIDS cohort study living Geneva (Switzerland, 2022). conducted an intersectional Multilevel Analysis Individual Heterogeneity...
The FapR protein of Bacillus subtilis has been shown to play an important role in membrane lipid homeostasis. acts as a repressor many genes involved fatty acid and phospholipid metabolism (the fap regulon). binding DNA is antagonized by malonyl-CoA, thus sensor the status biosynthesis. However, malonyl-CoA utilized for synthesis only following its conversion malonyl-ACP, which plays central initiation elongation cycles carried out type II synthase. Using vitro transcription studies...
Background: More than two years into the COVID-19 pandemic, it is generally assumed that most of population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making hindered by lack up-to-date and precise characterization immune landscape in population. We thus aimed to estimate seroprevalence cross-variant neutralization capacity after Omicron became dominant Geneva, Switzerland. Methods: conducted a population-based serosurvey...
Mental health deteriorated in the early stages of COVID-19 pandemic, but improved relatively quickly as restrictions were eased, suggesting overall resilience. However, longer-term follow-up mental general population is scarce.
Abstract Background The present analysis aimed to assess the mediating role of psychosocial and behavioural factors in socio-economic inequalities health-related quality life (HRQoL) among children adolescents. Methods Cross-sectional data was drawn from randomly selected SEROCoV-KIDS cohort study Geneva, Switzerland. Associations conditions (parents’ highest education, household financial situation) with HRQoL, (parent–child relationship, school difficulties, friends, extracurricular...
Fet3p from Saccharomyces cerevisiae is a multicopper oxidase (MCO) which oxidizes Fe2+ to Fe3+. The electronic structure of the different copper centers in this family enzymes has been extensively studied and discussed for years with particular focus on exchange coupling regime trinuclear cluster (TNC). Using NMR spectroscopy we have quantified constant type 3 center fully metalated oxidase; value significantly higher than that reported proteins containing isolated as tyrosinase. We also...
Objectives This cohort study including essential workers, assessed the risk and incidence of SARS-CoV-2 infection during second surge COVID-19 according to baseline serostatus occupational sector. Methods Essential workers were selected from a seroprevalence survey in Geneva, Switzerland linked state centralised registry compiling infections. Primary outcome was virologically confirmed infections serological assessment (between May September 2020) 25 January 2021, antibody status stratified...
The electronic structure of heme proteins is exquisitely tuned by the interaction iron center with axial ligands. NMR studies paramagnetic systems have been focused on signals, but signals from ligands rather difficult to detect and assign. We report an extensive assignment (1)H, (13)C (15)N resonances His ligand in NO-carrying protein nitrophorin 2 (NP2) high-spin low-spin forms, as well diamagnetic NO complex. find that has σ spin delocalization all atoms His57, which decreases size number...
Abstract We report a prospective epidemiological, virological and serological investigation of SARS-CoV-2 outbreak in primary school, as part longitudinal, prospective, school-based surveillance study. It involved repeated testing pupils teachers household members participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0-2 Day 5-7), serologies on dried capillary blood samples 30), contact tracing interviews whole genome sequencing. This caused by the Alpha variant 20...
Abstract Objective This study aimed to assess acceptance of COVID-19 vaccination as well its sociodemographic and clinical determinants in a general population sample three months after the launch program Switzerland. Methods In March 2021, an online questionnaire on was proposed adults included longitudinal cohort previous population-based serosurveys carried out canton Geneva. Questions were asked about acceptance, reasons or refusal, attitudes general. Data demographic (age, sex,...