Mayssam Nehme
A5058437184- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vaccine Coverage and Hesitancy
- Health disparities and outcomes
- Healthcare Systems and Practices
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 detection and testing
- Health, Medicine and Society
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Healthcare professionals’ stress and burnout
- Mobile Health and mHealth Applications
- Chronic Disease Management Strategies
- COVID-19 Impact on Reproduction
- Nutritional Studies and Diet
- Multiculturalism, Politics, Migration, Gender
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Sleep and related disorders
- Psychosomatic Disorders and Their Treatments
- Peripheral Neuropathies and Disorders
- Digital Mental Health Interventions
University Hospital of Geneva
2020-2025
University of Geneva
2022-2025
Hôpital Beau-Séjour
2020-2025
Geneva College
2021-2024
Letters8 December 2020COVID-19 Symptoms: Longitudinal Evolution and Persistence in Outpatient SettingsFREEMayssam Nehme, MD, Olivia Braillard, Gabriel Alcoba, Sigiriya Aebischer Perone, Delphine Courvoisier, PhD, François Chappuis, Idris Guessous, for the COVICARE TEAM†Mayssam MDGeneva University Hospitals, Geneva, SwitzerlandSearch more papers by this author, Hospitals Médecins Sans Frontières, International Committee of Red Cross, PhDGeneva TEAM†Search authorAuthor, Article, Disclosure...
With millions of SARS-CoV-2 infections worldwide, increasing numbers patients are coming forward with long-term clinical effects the disease lasting several weeks to months.
Abstract Understanding the risk of infection from household- and community-exposures transmissibility asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence based primarily on virologic testing, which disproportionately misses mild infections. Serologic measures are more likely capture all previously infected individuals. We apply household transmission models data a cross-sectional, household-based population serosurvey 4,534 people ≥5 years 2,267 households...
Abstract Background Serological assays detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are being widely deployed in studies and clinical practice. However, the duration effectiveness of protection conferred by immune response remains to be assessed population-based samples. To estimate incidence newly acquired SARS-CoV-2 infections seropositive individuals as compared seronegative controls, we conducted a retrospective longitudinal matched study....
Lack of awareness cognitive impairment (i.e. anosognosia) could be a key factor for distinguishing between neuropsychological post-COVID-19 condition phenotypes. In this context, the 2-fold aim present study was to (i) establish prevalence anosognosia memory impairment, according severity infection in acute phase and (ii) determine whether anosognosic patients with post-COVID syndrome have different psychiatric profile from nosognosic patients, associated differences brain functional...
To describe long-COVID symptoms among older adults and to assess the risk factors for two common symptoms: fatigue dyspnea.This is a multicenter, prospective cohort study conducted in Israel, Switzerland, Spain, Italy. Individuals were included at least 30 days after their COVID-19 diagnosis. We compared between elderly (aged >65 years) younger individuals 18-65 univariate multivariable analyses predictors of dyspnea.A total 2333 evaluated an average 5 months (146 [95% confidence interval...
Neuropsychological deficits and brain damage following SARS-CoV-2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological olfactory tests, as completed psychiatric respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients functional magnetic resonance imaging. Patients severe group displayed poorer verbal episodic memory performances, moderate had reduced...
Long COVID has become a burden on healthcare systems worldwide. Research into the etiology and risk factors been impeded by observing all diverse manifestations as part of single entity. We aimed to determine patterns symptoms in convalescing COVID-19 patients.Symptomatic patients were recruited from four countries. Data collected regarding demographics, comorbidities, acute disease persistent symptoms. Factor analysis was performed elucidate symptom patterns. Associations with patients'...
More than two years into the COVID-19 pandemic, most of population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making is hindered by lack up-to-date and precise characterization immune landscape in population. Here, we estimated seroprevalence cross-variant neutralization capacity after Omicron became dominant Geneva, Switzerland.We conducted a population-based serosurvey between April 29 June 9, 2022, recruiting children adults...
The medium-term impact of the COVID-19 pandemic on wellbeing children and adolescents remains unclear. More than 2 years into pandemic, we aimed to quantify frequency determinants having been severely impacted by estimate its health-related quality life (HRQoL) mental health.
Abstract Limited data exist on SARS-CoV-2 infection rates across sectors and occupations, hindering our ability to make rational policy, including vaccination prioritization, protect workers limit spread. Here, we present results from SEROCoV-WORK + study, a serosurvey of recruited after the first wave COVID-19 pandemic in Geneva, Switzerland. We tested (May 18—September 18, 2020) 16 32 occupations for anti-SARS-CoV-2 IgG antibodies. Of 10,513 participants, 1026 (9.8%) positive. The...
Post-COVID condition is prevalent in 10-35% of cases outpatient settings, however a stratification the duration and severity symptoms still lacking, adding to complexity heterogeneity definition post-COVID its oucomes. In addition, potential impacts longer disease are not yet clear, along with which risk factors associated chronification beyond initial 12 weeks. this study, follow-up was conducted at 7 15 months after testing SARS-CoV-2 center Geneva University Hospitals. The defined as...
Persistent symptoms of SARS-CoV-2 are prevalent weeks to months following the infection. To date, it is difficult disentangle direct from indirect effects SARS-CoV-2, including lockdown, social, and economic factors.The study aims characterize prevalence symptoms, functional capacity, quality life at 12 in outpatient symptomatic individuals tested positive for compared negative.From 23 April 27 July 2021, Geneva University Hospitals were followed up after their test date.At months, out 1447...
Post-coronovirus disease (COVID) symptoms can persist several months after severe acute respiratory syndrome coronavirus 2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron variants and how this varies according to vaccination status. This study evaluates functional impairment 12 weeks an infection by (BA.1 BA.2) compared with negative controls tested during same period.Outpatient individuals who positive or for COVID-19...
Several studies have reported poor long-term neuropsychological performances in patients following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but none has yet considered the effect of administering multiple intercorrelated tests and assessed frequency cognitive deficits a normative population. Our aim was therefore to assess presence cumulative an actual post-coronavirus disease 2019 (COVID-19) comparison group versus one simulated using Monte-Carlo...
Alterations of the limbic system may be present in chronic phase SARS-CoV-2 infection. Our aim was to study long-term impact this disease on system-related behaviour and its associated brain functional connectivity, according severity respiratory symptoms acute phase. To end, we investigated multimodal emotion recognition abilities 105 patients from Geneva COVID-COG Cohort 223 days average after infection (diagnosed between March 2020 May 2021), dividing them into three groups (severe,...
Abstract Background SARS‐CoV‐2 infection triggers different auto‐antibodies, including anti‐apolipoprotein A‐1 IgGs (AAA1), which could be of concern as mediators persistent symptoms. We determined the kinetics AAA1 response over after COVID‐19 and impact on inflammatory symptoms persistence. Methods All serologies were assessed at one, three, six twelve months in 193 hospital employees with COVID‐19. ROC curve analyses logistic regression models (LRM) used to determine prognostic accuracy...
Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection infection with pre-Omicron lineages. This has been challenged by the emergence immune-evasive variants, notably Omicron sublineages, in an evolving immune landscape high cumulative incidence and vaccination coverage. turn limits use widely available commercial high-throughput methods quantify binding antibodies as a tool monitor at population-level. Here we show that anti-Spike RBD levels, quantified...
Despite numerous observations of neuropsychological deficits immediately following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, little is known about what happens to these over time and whether they are affected by changes in fatigue any psychiatric symptoms. We aimed assess the prevalence at 6-9 months again 12-15 after disease 2019 (COVID-19) explore it was associated with
Objectives This study aims (1) to assess the prevalence of severe fatigue among general population Geneva, 2 years into COVID-19 pandemic and (2) identify non-pandemic factors associated with fatigue. Design Cross-sectional population-based survey conducted in Spring 2022. Setting General adult Switzerland. Participants 6870 participants, randomly selected from population, included Specchio-COVID-19 cohort study, were invited answer an online health survey. Outcome cofactor measure...
The COVID-19 pandemic, starting in 2020, raised concerns about potential long-term health impacts, including its effects on cardiovascular and related biomarkers. This study part of the Bus Santé Geneva, Switzerland, compared metabolic profiles pre- (2016-2019) post-pandemic (2023-2024) among individuals aged 30-75. Participants completed questionnaires underwent a clinical visit, physical examination fasting blood test to assess lipid glycemic profiles. Linear regression was used estimate...
Social inequalities in sleep have been reported, but there is less research on the mechanisms underlying this association. This study investigates relationship between financial hardship and within general adult population, focusing mediating effects of psychosocial lifestyle-related factors. We used data from Specchio cohort, a population-based Geneva, Switzerland, initiated December 2020. Perceived outcomes (insomnia, quality, duration) were assessed by questionnaire 2020 to 2021....
The COVID-19 pandemic prompted significant shifts to teleworking, raising questions about potential impacts on employee wellbeing. This study examined the association between self-reported changes teleworking frequency (relative before pandemic) and two indicators of occupational burnout: emotional exhaustion professionally diagnosed burnout. Data were derived from samples a digital cohort based in Geneva, Switzerland: one population-based, sample workers who likely mobilized early stages...