A5060113955- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- COVID-19 and Mental Health
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Action Observation and Synchronization
- Genetic Neurodegenerative Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurobiology of Language and Bilingualism
- Intensive Care Unit Cognitive Disorders
- Olfactory and Sensory Function Studies
- Neural and Behavioral Psychology Studies
- Neuroscience and Music Perception
- Hearing, Cochlea, Tinnitus, Genetics
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Balance, Gait, and Falls Prevention
- Botulinum Toxin and Related Neurological Disorders
- Stuttering Research and Treatment
- Psychoanalysis and Psychopathology Research
- Traumatic Brain Injury Research
University Hospital of Geneva
2017-2025
University of Geneva
2016-2025
Geneva College
2022-2024
Hôpital Beau-Séjour
2023
Centre Hospitalier Universitaire de Rennes
2006-2022
Université de Rennes
2008-2022
FORS – Swiss Centre of Expertise in the Social Sciences
2018
Université de Picardie Jules Verne
2016
Centre Hospitalier Universitaire Amiens-Picardie
2016
Université Paris Nanterre
2015
Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy STN-DBS correlates with changes glucose metabolism, using (18)FDG-PET.Twelve patients PD were assessed 3 months before (M-3) and after (M+3) (18)FDG-PET Evaluation Scale.Apathy had significantly worsened at M+3 STN-DBS. Positive correlations observed between this variation scores especially right frontal middle gyrus (Brodmann area...
Lack of awareness cognitive impairment (i.e. anosognosia) could be a key factor for distinguishing between neuropsychological post-COVID-19 condition phenotypes. In this context, the 2-fold aim present study was to (i) establish prevalence anosognosia memory impairment, according severity infection in acute phase and (ii) determine whether anosognosic patients with post-COVID syndrome have different psychiatric profile from nosognosic patients, associated differences brain functional...
There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, even in its mild or moderate forms, can include long-term neuropsychological deficits. Standardized neuropsychological, psychiatric, neurological, and olfactory tests were administered to 45 patients 236.51 ± 22.54 days after hospital discharge following severe, moderate, severity from SARS-CoV-2 infection (severe = intensive care unit hospitalization, conventional no hospitalization)....
Neuropsychological deficits and brain damage following SARS-CoV-2 infection are not well understood. Then, 116 patients, with either severe, moderate, or mild disease in the acute phase underwent neuropsychological olfactory tests, as completed psychiatric respiratory questionnaires at 223 ± 42 days postinfection. Additionally, a subgroup of 50 patients functional magnetic resonance imaging. Patients severe group displayed poorer verbal episodic memory performances, moderate had reduced...
Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and a recent study, we found fear recognition be impaired result. These changes have been attributed disturbance STN's limbic territory would appear confirm that negative emotion network passes through STN. In addition, it now widely acknowledged damage orbitofrontal cortex (OFC), especially right side, can result facial emotions...
We sought to identify apathy metabolic bases in Parkinson disease (PD).A total of 45 patients with PD who were not clinically depressed (Montgomery-Åsberg Depression Rating Scale [MADRS] <21) and had no dementia (Mattis Dementia [MDRS] >130) assessed the Apathy Evaluation (AES) underwent a resting-state F-18 fluorodeoxyglucose PET (FDG-PET) scan. A motor assessment comprising Unified Parkinson's Disease Part III (UPDRS-III) was conducted levodopa equivalent daily dose (LEDD) calculated....
Apathy is a disabling non-motor symptom that frequently observed in Parkinson9s disease (PD). Its description and physiopathology suggest it partially mediated by emotional impairment, but this research issue has never been addressed at clinical metabolic level. We therefore conducted study using <sup>18</sup>fluorodeoxyglucose positron emission tomography (<sup>18</sup>FDG PET) 36 PD patients without depression dementia. was assessed on the Evaluation Scale (AES), facial recognition (EFR)...
Several studies have reported poor long-term neuropsychological performances in patients following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but none has yet considered the effect of administering multiple intercorrelated tests and assessed frequency cognitive deficits a normative population. Our aim was therefore to assess presence cumulative an actual post-coronavirus disease 2019 (COVID-19) comparison group versus one simulated using Monte-Carlo...
Alterations of the limbic system may be present in chronic phase SARS-CoV-2 infection. Our aim was to study long-term impact this disease on system-related behaviour and its associated brain functional connectivity, according severity respiratory symptoms acute phase. To end, we investigated multimodal emotion recognition abilities 105 patients from Geneva COVID-COG Cohort 223 days average after infection (diagnosed between March 2020 May 2021), dividing them into three groups (severe,...
Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) can produce emotional disorders that have been linked to disturbance of the STN's limbic territory. The aim this study was confirm impairment recognition facial emotions (RFE) induced by STN DBS, not only ruling out effect disease's natural progression relation but also assessing influence modifications dopamine replacement therapy (DRT) following DBS. RFE investigated 24 PD patients who underwent...
High-frequency deep brain stimulation (DBS) represents a major stake for treatment treatment-resistant depression (TRD). We describe preliminary trial of DBS two potential targets in chronic TRD: the nucleus accumbens (Acb) and, event failure, caudate nucleus. Patients were followed 6 months before surgery (M0). From M1 to M5, they underwent Acb target. PET scans allowed us track metabolic modifications resulting from this stimulation. The target nonresponders was stimulated between M5 and...
<h3>Objective:</h3> The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, no information about cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. <h3>Methods:</h3> To resolve this issue, we set out to identify factors increased STN-DBS. Forty-four patients disease were enrolled study. They all underwent Metabolic activity was assessed F-18...
Despite numerous observations of neuropsychological deficits immediately following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, little is known about what happens to these over time and whether they are affected by changes in fatigue any psychiatric symptoms. We aimed assess the prevalence at 6-9 months again 12-15 after disease 2019 (COVID-19) explore it was associated with