A5069848705- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Diet, Metabolism, and Disease
- Vagus Nerve Stimulation Research
- Gastroesophageal reflux and treatments
- Heart Rate Variability and Autonomic Control
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Clinical Nutrition and Gastroenterology
- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Neuroscience of respiration and sleep
- Dietary Effects on Health
- EEG and Brain-Computer Interfaces
- Pancreatic function and diabetes
- Animal Behavior and Welfare Studies
- Cardiovascular Syncope and Autonomic Disorders
- Olfactory and Sensory Function Studies
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2015-2024
Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
2022-2023
Université de Lille
2023
The University of Adelaide
1995-2021
Académie Nationale de Médecine
2015-2021
Unité de Nutrition Humaine
2019-2021
Département Alimentation Humaine
2009-2019
GTx (United States)
2017
Institut National de la Recherche Agronomique
1994-2015
The pig model is increasingly used in the field of neuroscience because similarities its brain with human. This review presents peculiarities anatomy and functions specific reference to human counterpart. We propose an approximate mapping pig's cortical areas since a comprehensive description equivalent Brodmann's lacking. On contrary, deep structures are received more consideration but true three-dimensional (3D) atlas still eagerly required. In second section, we present overview former...
Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy STN-DBS correlates with changes glucose metabolism, using (18)FDG-PET.Twelve patients PD were assessed 3 months before (M-3) and after (M+3) (18)FDG-PET Evaluation Scale.Apathy had significantly worsened at M+3 STN-DBS. Positive correlations observed between this variation scores especially right frontal middle gyrus (Brodmann area...
The aim of this study was to evaluate the nervous and humoral pathways involved in short-chain fatty acid (SCFA)-induced ileal brake conscious pigs. role extrinsic innervation evaluated after SCFA infusion innervated denervated Babkin's loops, gastric motility measured with strain gauges. Peptide YY (PYY) glucagon-like peptide-1 (GLP-1) concentrations were both situations. possible involvement absorbed tested by using intravenous acetate. Ileal intact terminal ileum decreased amplitude...
Deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) in Parkinson's disease is thought to produce adverse events such as emotional disorders, and a recent study, we found fear recognition be impaired result. These changes have been attributed disturbance STN's limbic territory would appear confirm that negative emotion network passes through STN. In addition, it now widely acknowledged damage orbitofrontal cortex (OFC), especially right side, can result facial emotions...
Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity if this would relate function. Sixteen pigs were subjected sodium (SB) supplementation via beverage water or only [control (C)]. All had blood sampled after 2 3 wk of treatment, a positron emission tomography wk. Animals euthanized 4 sample pancreas, intestine, for physiology anatomy...
To evaluate the effects of 8 weeks' administration exenatide (EXE) once weekly on gastric emptying solids and liquids (using "gold standard" technique, scintigraphy), glucose absorption postprandial glycaemia in healthy people.A total 32 participants were randomized to receive either EXE (2 mg/wk subcutaneously; six men, 10 women, mean age 59.9 ± 0.9 years, body mass index [BMI] 29.6 0.6 kg/m2 ) or matching placebo (PBO; 60.6 1.2 BMI 29.5 1.0 for weeks. Gastric emptying, nausea (visual...
Compared to lean subjects, obese men have less activation in the dorsolateral prefrontal cortex, a brain area implicated inhibition of inappropriate behavior, satiety, and meal termination. Whether this deficit precedes weight gain or is an acquired feature obesity remains unknown. An adult animal model may provide insight question since imaging can be performed vs. conditions controlled study. Seven diet‐induced minipigs were compared nine housed same conditions. Brain after overnight...
Acute vagal stimulation modifies glucose and insulin metabolism, but the effect of chronic bilateral is not known. Our aim was to quantify changes in whole-body organ-specific sensitivities 12 weeks after permanent, bilateral, performed at abdominal level adult mini-pigs. In 15 mini-pigs, stimulating electrodes were placed around dorsal ventral vagi using laparoscopy connected a dual-channel stimulator subcutaneously. Animals divided into three groups based on body weight (i.e., lean...
The effect of dietary fibre on the gastric emptying rate solids is controversial. Similarly, mechanisms by which it modulates food intake are partially unknown. Gastric and proximal v. distal stomach filling were evaluated in triplicate four conscious pigs using scintigraphic imaging. Each animal received an isoenergetic manner a concentrate low-fibre diet enriched starch (S) two high-fibre diets based sugar beet pulp (BP) or wheat bran (WB). All meals had same viscosity before ingestion...
Gastric emptying of food is mainly driven by the caloric concentration, rheological properties chyme, and physical state (liquid/solid) once in stomach. The present work investigated: (1) effect composition viscosity drinkable yogurts on gastric pigs, (2) behavior during dynamic vitro digestion. Three isocaloric liquid were manufactured: Two enriched protein fiber showing either a low (LV) or high (HV) viscosity, one control sugar starch (CT). They labelled with 99mTc-sulfur colloid given to...
The aim of the present study was to describe and validate a computed tomography (CT) method analyse adiposity distribution in Göttingen minipigs. Adiposity evaluated two groups In group 1 ( n 8), measurements were performed before after induction obesity. 2 7), animals fed rations designed obtain heterogeneous analyses. CT acquisitions associated with anatomical, ultrasonography body chemical measurements. Our based on acquisition single slice at fixed anatomical landmark, calculation...
Incidence of diarrhea at weaning in commercial pigs is an important problem, and diet thought to be a predisposing factor. The aim this study was determine the impact switching from milk-based cereal-based diets on morphology function small intestine piglets using model delayed isolate influence that environmental social factors.Forty-five received for 5 weeks after weaning. Thirty were then switched wheat- or barley-based diets, mimicking dietary change occurs last 15 remained diet. Piglets...
Acidosis impairs smooth muscle function in various organs. However, the effects of acidosis on gastroduodenal tract are unknown while its dysfunction has potential perioperative harmful consequences. We investigated metabolic (MA) and respiratory (RA) upper gut motility tracheally ventilated pigs whose anesthesia was induced with halothane maintained alpha-chloralose-urethane administration (IV). Increased dead space perfusion hydrochloric acid 1 N (150 mL over 30 min) were used to induce RA...
The cutaneous electrogastrogram (EGG) and intraluminal antropyloroduodenal pressures were recorded in 12 healthy volunteers for 30-min periods during phase II of the interdigestive motor complex, intraduodenal infusion 10% triglyceride, after intravenous erythromycin (3 mg/kg). During II, frequency EGG was relatively constant each individual, with a median 0.046 Hz [2.8 counts per minute (cpm)]. greater (P < 0.05) than rate antral pressure waves (1.8 cpm). suppression stimulation isolated...
1. In eight conscious pigs equipped with gastric and duodenal cannulae, the relationship of transpyloric flow to gastro-duodenal motor events was evaluated during emptying 1000 ml saline. Rates liquid were correlated pressures at antrum, pylorus duodenum, recorded by a sleeve sensor multiple perfused side-holes. Transpyloric concurrently continuous collection weighing effluent. 2. three above measurements repeated concurrent videofluoroscopy after adding 100 barium instillate. 3. The mean...