Background and aims: Transient lower oesophageal sphincter relaxations (TLOSRs) are the major cause of gastro-oesophageal reflux in normal subjects most patients with disease. The gamma aminobutyric acid (GABA) receptor type B agonist, baclofen, is a potent inhibitor TLOSRs subjects. aim this study was to investigate effect baclofen on postprandial Methods: In 20 disease, motility pH were measured, sitting position, for three hours after 3000 kJ mixed nutrient meal. On separate days at least...

A 500-mg dose of the quinoline ciprofloxacin was administered orally to each six healthy male volunteers, after which concentrations this agent in serum and blister fluid were measured. Absorption appeared be rapid, with a mean peak level 2.4 micrograms/ml attained 1.25 h administration. The elimination half-life 3.9 h. penetrated well, percent penetration being 57%. Urinary recovery 30%.

The mechanism that controls venting of gas from the stomach into oesophagus was studied manometrically in 14 healthy subjects. distended abruptly with one litre carbon dioxide. Gas reflux characterised by an abrupt increase basal oesophageal body pressure to intragastric pressure. Reflux occurred during transient lower sphincter relaxations generally had a pattern distinctly different swallow-induced relaxation. Thus, at onset episode relaxed 3 mmHg, or less, 96% instances. After loading...

A 100-mg dose of ciprofloxacin was given as an intravenous bolus injection to each six healthy volunteers, after which the levels this agent were measured in serum, blister fluid, and urine. After administration, distribution very rapid, mean volume large (177 liters). The terminal serum half-life 4.0 h. penetrated fluid rapidly, with maximum level being 0.53 micrograms/ml at 30 min, time exceeded those serum. 48-h urinary recovery about 80%.

The relation between pyloric motor activity, opening, and closure was examined in eight healthy men. Manometry performed with an assembly combining 13 side holes a sleeve sensor positioned astride the pylorus. Simultaneous manometry, opening antroduodenal contractions were observed fluoroscopically antrum filled barium. During intraduodenal normal saline infusion, coordinated antral pressure waves swept over pylorus ejected barium into duodenum. No localised pattern under these conditions....

Recent studies suggest that the pylorus may play an important role in regulation of gastric emptying nutrient liquids man. Dextrose solutions range 5-25 g/dl have been reported to empty from human stomach at a constant caloric rate 2.1 kcal/min. This study examined, 12 healthy volunteers, effects intraduodenal dextrose on pyloric motility. solutions, 5, 10, 15, and 25 gde/dl saline 0.9 2.7 were infused into duodenum 4 ml/min for 10 minutes. Antral, pyloric, duodenal motility monitored with...

There is little information about the organisation of antroduodenal contractions or pyloric motility in patients with gastroparesis. The mechanisms responsible for acceleration gastric emptying by cisapride gastroparesis are also poorly understood. Simultaneous manometric and scintigraphic recordings were performed 12 nine healthy volunteers before after administration. Antropyloroduodenal pressures recorded a sleeve/side hole assembly method. Thirty minutes solid component test meal had...

BACKGROUND: Gastro-oesophageal reflux disease causes significant morbidity in premature infants, but the role of dysfunction lower oesophageal sphincter (LOS) this condition is unclear. METHODS: Oesophageal manometry was performed after gavage feeding 13 healthy preterm neonates (postmenstrual age > or = 33 weeks) with a perfused sleeve side hole assembly. Swallow related (both single and multiple) transient LOS relaxations (TLOSRs) were identified characteristics these events defined....

BACKGROUND AND AIMS: Fatty foods are commonly reported to aggravate gastro-oesophageal reflux symptoms. In this study the hypothesis that fat provokes by stimulating transient lower oesophageal sphincter relaxations via small intestinal receptors was investigated. METHODS: 12 healthy volunteers and 11 patients with oesophagitis, motility pH were measured over 30 minute periods during which saline or (10% Intralipid) infused in random order into duodenum. The infusion separated a washout....

Summary Background : Helicobacter pylori infection has been proposed as a protective factor against the development of gastro‐oesophageal reflux disease. Aim To study heartburn and endoscopic findings before after H. eradication therapy in patients with peptic ulcer Methods In multicentre trial programme, ( n = 1497) were randomized to omeprazole triple group or control group, followed for 1–6 months treatment. Patients whom was eradicated compared those persisted. The severity measured at...

BACKGROUND/AIMS: To evaluate the role of upper oesophageal sphincter (UOS) compliance in dysphagia, functional consequences surgery were evaluated eight patients with pharyngeal diverticula. The study examined hypotheses that hypopharyngeal intrabolus pressure is an indicator UOS and opening are normalised by surgery. METHODS: In nine healthy controls, we measured timing swallow events, relaxation, maximal dimensions, pressure, trans-sphincteric bolus flow rates simultaneous videoradiography...

The aim of this study was to evaluate the axial and radial distribution histological markers including hyperplasia basal cell layer, elongation papillae dilatation intercellular spaces squamous epithelium in patients with nonerosive reflux disease compared controls relate macroscopic topography erosive disease. Two different populations were included report. Endoscopic esophageal biopsies taken from 21 healthy control subjects before after 4 weeks esomeprazole therapy. still images 50...

A combination of 3 g ticarcillin and 200 mg clavulanic acid was administered intravenously to six healthy male volunteers, after which the concentrations these agents in serum blister fluid were measured. The ratio two drugs varied from 15:1 (ticarcillin-clavulanic acid) at time administration 28:1 30 min 62:1 5 h injection. Both penetrated rapidly, being 33:1 1 66:1 h. elimination rates different, but for each compound they similar fluid.

The pharmacokinetics of the quinolone enoxacin were studied after a 600-mg oral dose was given to each six male volunteers. levels compound measured in serum, blister fluid, and urine. Absorption variable, with peak (mean, 3.7 micrograms/ml) being attained between 0.75 3.0 h 1.9 h). serum elimination half-life 6.2 h, 71.6% drug recovered urine by 48 h. Enoxacin penetrated fluid well, mean percent penetration 78.4%.

The cutaneous electrogastrogram (EGG) and intraluminal antropyloroduodenal pressures were recorded in 12 healthy volunteers for 30-min periods during phase II of the interdigestive motor complex, intraduodenal infusion 10% triglyceride, after intravenous erythromycin (3 mg/kg). During II, frequency EGG was relatively constant each individual, with a median 0.046 Hz [2.8 counts per minute (cpm)]. greater (P < 0.05) than rate antral pressure waves (1.8 cpm). suppression stimulation isolated...

1. In eight conscious pigs equipped with gastric and duodenal cannulae, the relationship of transpyloric flow to gastro-duodenal motor events was evaluated during emptying 1000 ml saline. Rates liquid were correlated pressures at antrum, pylorus duodenum, recorded by a sleeve sensor multiple perfused side-holes. Transpyloric concurrently continuous collection weighing effluent. 2. three above measurements repeated concurrent videofluoroscopy after adding 100 barium instillate. 3. The mean...

1. In six conscious pigs antral, pyloric and duodenal pressures were recorded with a 5.5 cm sleeve sensor multiple perfused side holes. The manometric assembly was positioned by dual point transmucosal potential difference measurement. Gastric emptying measured drainage of the proximal duodenum through Thomas cannula. Pressures correlated ingested radiolabelled 5% dextrose. Alteration produced infusion into more distal nutrient non‐nutrient solutions differing osmolalities. 2. Motor activity...

Recent studies suggest that scintigraphy can be used to evaluate non-invasively antral motility in humans, although scintigraphic techniques have not yet been compared with more conventional measurements of intraluminal pressures by manometry. Simultaneous and manometric were performed nine healthy volunteers. After intubation a sleeve/sidehole catheter which incorporated five pressure sideholes located at 1.5 cm intervals spanning the antrum, each subject ingested 100 g minced beef labelled...

The influence of gravity, if any, on pharyngeal bolus transport is unknown. aim the present study was to evaluate effect gravity and body position radiological manometric events during normal oropharyngeal swallow. In eight healthy male volunteers, we performed simultaneous videoradiography manometry, using a manometry catheter incorporating perfused sleeve measuring upper esophageal sphincter pressure three solid-state transducers recording pressures. Swallows 5 10 ml barium were in...

Aliment Pharmacol Ther 2010; 32: 1023–1030 Summary Background Acid reflux is often difficult to control medically. Aim To assess the effect of 40 mg twice daily esomeprazole (high‐dose) on gastric and oesophageal pH symptoms, biomarkers relevant adenocarcinoma, in patients with Barrett’s oesophagus (BO). Methods Eighteen patients, treated proton pump inhibitors as prescribed by their treating doctor, had therapy increased high‐dose for 6 months. Results At entry into study, 9/18 excessive...

Background Reflux symptoms (heartburn and regurgitation) are common in patients with functional dyspepsia who do not have gastroesophageal reflux disease (GERD). Objective The purpose of this study was to assess the relationship sleep disturbances without GERD those GERD. Methods This post‐hoc analysis data from Diamond (NCT00291746) included frequent upper gastrointestinal symptoms, whom 137 had 193 (diagnosed by endoscopy pH monitoring). Patients completed symptom questionnaires were...