A5056617238- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Inflammatory Bowel Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Kawasaki Disease and Coronary Complications
- Hepatitis B Virus Studies
- Moyamoya disease diagnosis and treatment
- Neonatal Health and Biochemistry
- Sphingolipid Metabolism and Signaling
- Dysphagia Assessment and Management
- Liver Disease and Transplantation
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Viral Infections and Outbreaks Research
- Neurosurgical Procedures and Complications
Tokyo Medical and Dental University
2013-2024
Tokyo Metropolitan Police Hospital
2022-2024
Itami City Hospital
2003-2017
Osaka University
1987-2017
National Center for Global Health and Medicine
2017
Tokyo Medical and Dental University Hospital
2013
Tsuchiura Kyodo General Hospital
2011-2013
Tokyo Metropolitan Bokutoh Hospital
2012
Musashino Red Cross Hospital
2012
Kobe University
2009
<h3>Importance</h3> Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy patients acute large vessel occlusion stroke unclear. <h3>Objective</h3> To examine whether alone noninferior to combined plus for favorable poststroke outcome. <h3>Design, Setting, and Participants</h3> Investigator-initiated, multicenter, randomized, open-label, noninferiority clinical trial 204 ischemic due enrolled at 23 hospital networks Japan from January 1, 2017, July 31, 2019,...
Five methods have been used in an effort to reveal antibody that could account for the features of acquired resistance Listeria monocytogenes: (a) a comparison growth rates spleens mice infused repeatedly with normal or immune mouse serum; (b) measurement peritoneal clearance presence (c) survival rate monolayers macrophages infected (d) effect injecting urea extracts and on recipient animals; (e) lethally following passive transfer cells serum from donors. The only evidence protection was...
Abstract We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected bilateral common carotid artery stenosis with external microcoils (inner diameters: 0.16 mm, left; 0.18 right). Mice categorized according left‐side blood flow (CBF) value on day 6 into those severe hypoperfusion (SCH; n 16, < 30%...
Rationale Bridging therapy with endovascular (EVT) and intravenous thrombolysis (IVT) has been reported to improve outcomes for acute stroke patients large-vessel occlusion in the anterior circulation. While IVT may increase reperfusion rate, risk of hemorrhagic complications increases. Whether EVT without (direct EVT) is equally effective as bridging remains unclear. Aim This randomized study versus tissue plasminogen activator ICA M1 aims clarify efficacy safety direct compared therapy....
Oral function deteriorates easily during the acute phase of cerebral stroke. Therefore, oral health care involving a transdisciplinary approach consisting dental and medical professionals might be important, but has not been studied in detail.This study assessed status patients with stroke phase, aim elucidating efficacy collaborative, dentists, hygienists, nurses speech therapists.The participants were 115 consecutive patients, who received while hospitalised at university hospital. Their...
BACKGROUND: Gastro-oesophageal reflux disease causes significant morbidity in premature infants, but the role of dysfunction lower oesophageal sphincter (LOS) this condition is unclear. METHODS: Oesophageal manometry was performed after gavage feeding 13 healthy preterm neonates (postmenstrual age > or = 33 weeks) with a perfused sleeve side hole assembly. Swallow related (both single and multiple) transient LOS relaxations (TLOSRs) were identified characteristics these events defined....
Determination of intestinal permeability by measuring nonmetabolized sugars has been used to assess the integrity mucosa. We have developed and validated a modified HPLC method for determining concentration L-rhamnose, mannitol, lactulose in urine, using an amine-modified silica column refractive index detection. Probe are simultaneously resolved within 18 min. The calibration curve each sugar is linear 20 mmol/L. minimum detectable 0.05 Recovery probe between 99.3% 105.1%. Overall precision...
We studied the effect of Sho-saiko-to (Xiao-Chai-Hu-Tang) on HBeAg clearance rate (SN rate) in fourteen children with chronic hepatitis B virus (HBV) infection and sustained liver disease. Seven patients (50.0%) became negative average observation period 0.47 years(0.2-0.9 years). Four those seven developed anti-HBe. The annual SN She-saiko-to treated group was apparently higher than natural (22.7%) 22 untreated retrospectively reviewed from onset hepatitis. seemed to promote HBV may be a...
Sixteen cases of transient infantile hyperthyrotrophinaemia were followed up for two to seven years. Concentrations serum triiodothyronine, thyroxine, and free thyroxine maintained within the normal range in all cases. All but one child, who had a hearing disturbance, showed mental development with physical skeletal maturation. Eleven children concentrations thyroid stimulating hormone no signs or symptoms dysfunction; three children, diffuse small goitres developed further relapse slightly...
<h3>BACKGROUND AND PURPOSE:</h3> Predicting response to rtPA is essential in the era of endovascular therapy for stroke. The purpose this study was elucidate prognostic factors early neurologic improvement and long-term outcome with respect development reversion leptomeningeal collaterals recanalization after acute ischemic <h3>MATERIALS METHODS:</h3> We analyzed consecutive patients proximal MCA occlusion treated from 2007 2012 at 2 hospital stroke centers. All routinely underwent brain MR...
Iodide transport defect (ITD) is a rare disorder causing congenital hypothyroidism. We previously reported that homozygous T354P mutation in the sodium/iodide symporter (NIS) gene caused ITD. To clarify prevalence of this mutation, artificial substitution introducing PCR followed by restriction enzyme analysis was developed as rapid screening method to detect mutation. Three apparently unrelated families with ITD, one patient low thyroidal 99mTc pertechnetate (99mTcO4−) uptake and 52 healthy...
Abstract This paper shows guidelines for the treatment of Crohn’s disease in children by Working Group Japanese Society Pediatric Gastroenterology, Hepatology and Nutrition (Chair: Yuichiro Yamashiro) Inflammatory Bowel Disease Akio Kobayashi). The points which these differ from those adult patients are as follows. (i) Total enteral nutrition form an elemental formula is indicated primary therapy with at onset well active stage. Oral mesalazine used together. (ii) parenteral (TPN) oral...
Collateral growth after acute occlusion of an intracranial artery is triggered by increasing shear stress in preexisting collateral pathways. Recently, sphingosine-1-phosphate receptor-1 (S1PR1) on endothelial cells was reported to be essential sensing fluid stress. Here, we evaluated the expression S1PR1 hypoperfused mouse brain and investigated effect a selective agonist leptomeningeal subsequent ischemic damage focal ischemia.In C57Bl/6 mice (n = 133) subjected unilateral common carotid...
Abstract The options for treating stroke are limited, but stem cells hold promise as a therapy because of their multipotency. Neuronal derived from mesenchymal (MSC) were reported to have more therapeutic effect than MSCs. For elucidating the mechanism neuronal cells, here we generated model focal cerebral infarction by performing left common carotid artery occlusion in adult gerbils. We transfected human trabecular bone‐derived MSCs (hMSCs) with Notch intracellular domain induce...
Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle occlusion. We hypothesized that this sign correlated improved functional outcome occlusion treated intravenous recombinant tissue plasminogen activator.Fifty acute ischemic stroke were activator from April 2007 to October 2009. All routinely underwent initial (first 3 hours) scans on admission, and additional follow-up (14-21 days...