A5029877886- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Atrial Fibrillation Management and Outcomes
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Sphingolipid Metabolism and Signaling
- Pharmacological Effects of Natural Compounds
- Neonatal and fetal brain pathology
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Myasthenia Gravis and Thymoma
- Macrophage Migration Inhibitory Factor
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury Research
- Glycogen Storage Diseases and Myoclonus
- Neurological Complications and Syndromes
- IL-33, ST2, and ILC Pathways
Tokyo Medical and Dental University
2014-2023
Saitama Red Cross Hospital
2023
Neurological Surgery
2008-2015
Satou Hospital
2013
Musashino Red Cross Hospital
2012
Tokyo Metropolitan Bokutoh Hospital
2012
Red Cross Hospital
2009
National Institute of Neurological Disorders and Stroke
2008
National Institutes of Health
2008
Japan Society for the Promotion of Science
2007
Abstract Transplantation of human neural stem cells (NSCs) is a promising potential therapy for neurologic dysfunctions after the hyperacute stage stroke in humans, but large amounts NSCs must be expanded long‐term culture such therapy. To determine their possible therapeutic stroke, fetal stem/progenitor (NSPCs) (i.e., neurosphere‐forming cells) were isolated originally from forebrain tissues one fetus, and neurosphere (exceeding 24 weeks), then xenografted into lesioned areas brains...
In the subventricular zone of adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted proliferation NSCs in vitro by a recently developed proteomics technique, ProteinChip system. this screen, we identified soluble carbohydrate-binding protein, Galectin-1, as candidate. show herein Galectin-1 is expressed subset slowly dividing astrocytes, which includes NSCs. Based on results from intraventricular infusion...
Abstract We sought to establish a mouse model of subcortical ischemic vascular dementia (SIVD) that develops predominant white matter (WM) injury and cognitive dysfunction induced by chronic cerebral hypoperfusion. Adult C57Bl/6 male (n = 48) mice were subjected bilateral common carotid artery stenosis with external microcoils (inner diameters: 0.16 mm, left; 0.18 right). Mice categorized according left‐side blood flow (CBF) value on day 6 into those severe hypoperfusion (SCH; n 16, < 30%...
Myasthenia gravis (MG) is an autoimmune disease mostly caused by autoantibodies against acetylcholine receptor associated with thymus abnormalities. Thymectomy has been proven to be efficacious treatment for patients MG, but postoperative myasthenic crisis often occurs and a major complication. We aimed develop validate simple scoring system based on clinical characteristics in the preoperative status predict risk of crisis.We studied 393 MG who underwent thymectomy at 6 tertiary centers...
Neuroblasts in the subventricular zone (SVZ) proliferate markedly after brain ischemia, and migrate to site of injury along with blood vessels. However, a large fraction stroke-generated neuroblasts die shortly being born, part, because local inflammation. In spontaneously hypertensive rats (SHRs) subjected permanent middle cerebral artery occlusion, we primed E-selectin-specific regulatory T cells (Tregs) by repetitive intranasal administration recombinant E-selectin target secretion...
<h3>BACKGROUND AND PURPOSE:</h3> Predicting response to rtPA is essential in the era of endovascular therapy for stroke. The purpose this study was elucidate prognostic factors early neurologic improvement and long-term outcome with respect development reversion leptomeningeal collaterals recanalization after acute ischemic <h3>MATERIALS METHODS:</h3> We analyzed consecutive patients proximal MCA occlusion treated from 2007 2012 at 2 hospital stroke centers. All routinely underwent brain MR...
Schwann cells exhibit a high degree of plasticity in adult peripheral nerves after mechanical injury; they have, therefore, been implicated promoting nerve regeneration. However, cell behavior ischemic injury has not yet elucidated. To determine how may contribute to recovery from neuropathy, we used rat model which ischemia was induced the tibial by 5-hour occlusion supplying arteries. Proliferation immature that emerged injured evaluated double immunostaining for p75 neurotrophin receptor...
Collateral growth after acute occlusion of an intracranial artery is triggered by increasing shear stress in preexisting collateral pathways. Recently, sphingosine-1-phosphate receptor-1 (S1PR1) on endothelial cells was reported to be essential sensing fluid stress. Here, we evaluated the expression S1PR1 hypoperfused mouse brain and investigated effect a selective agonist leptomeningeal subsequent ischemic damage focal ischemia.In C57Bl/6 mice (n = 133) subjected unilateral common carotid...
Abstract The options for treating stroke are limited, but stem cells hold promise as a therapy because of their multipotency. Neuronal derived from mesenchymal (MSC) were reported to have more therapeutic effect than MSCs. For elucidating the mechanism neuronal cells, here we generated model focal cerebral infarction by performing left common carotid artery occlusion in adult gerbils. We transfected human trabecular bone‐derived MSCs (hMSCs) with Notch intracellular domain induce...
A 53-year-old man was admitted for sub-acute progressive dementia and Gerstmann syndrome. MRI demonstrated lesions in the white matter involving left parietal lobe, accompanied by speckled or faint linear peripheral enhancement. Brain biopsy revealed JC virus infection oligodendrocytes balanced infiltration of CD8+ CD4+ T lymphocytes. We diagnosed multifocal leukoencephalopathy (PML) with controlled inflammation. The finding CD4/CD8 cells infected PML brain suggested therapeutically valuable...
Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle occlusion. We hypothesized that this sign correlated improved functional outcome occlusion treated intravenous recombinant tissue plasminogen activator.Fifty acute ischemic stroke were activator from April 2007 to October 2009. All routinely underwent initial (first 3 hours) scans on admission, and additional follow-up (14-21 days...
Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels cerebrum accelerated phenotypic features AD when crossbred alpha-tocopherol transfer protein knockout (Ttpa-/-) mice. To further investigate chronic pathophysiology, we performed DNA microarray analysis using...