A5102835528- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Intestinal Malrotation and Obstruction Disorders
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Esophageal and GI Pathology
- Neuropeptides and Animal Physiology
- Clinical Nutrition and Gastroenterology
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Infant Nutrition and Health
- Kawasaki Disease and Coronary Complications
- Congenital gastrointestinal and neural anomalies
- Coronary Artery Anomalies
- Inflammatory mediators and NSAID effects
- Neonatal Health and Biochemistry
- Intestinal and Peritoneal Adhesions
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Ion channel regulation and function
- Pancreatitis Pathology and Treatment
Gunma Children's Medical Center
1998-2022
Japan Pediatric Society
2017-2022
Isesaki Fukushima Hospital
2006-2020
Ministry of Health Labour and Welfare
2018
Gunma University
2003-2017
Kyushu University
2015
Segawa Neurological Clinic for Children
2014
Showa University
2004-2006
Takasaki University of Health and Welfare
2006
Sapporo Kosei General Hospital
2006
In the present study, we developed models to predict unresponsiveness intravenous immunoglobulin (IVIG) in Kawasaki disease (KD).We reviewed clinical records of 546 consecutive KD patients (development dataset) and 204 subsequent (validation dataset). All received IVIG for treatment KD. nonresponders were defined by fever persisting beyond 24 hours or recrudescent associated with symptoms after an afebrile period. A 7-variable logistic model was constructed, including day illness at initial...
Allied disorders of Hirschsprung's disease (ADHD) have been proposed to be the concept functional obstruction intestine with presence ganglion cells in terminal rectum. They are classified into two categories based on pathology: (1) abnormal ganglia, including immaturity hypoganglionosis (HG), and intestinal neuronal dysplasia; (2) normal megacystis microcolon hypoperistalsis syndrome (MMIHS), segmental dilatation (SD), internal anal sphincter achalasia (IASA), chronic idiopathic...
Increased incidence and prevalence of pediatric inflammatory bowel disease (IBD) have been reported in Western countries. Changes the IBD Asian countries, however, remain unclear. We evaluated changes among Japanese adults children from 2004 to 2013, by using national registry data patients receiving financial aid. Data (ages 0-19 years) were compared with those young 20-39 years). In 2004, age-standardized prevalences Crohn (CD) ulcerative colitis (UC) 4.2 100,000 11.0 100,000,...
We studied gastrointestinal motility in 20 infants, using a modified manometric method for neonates, and compared it to that adults. Changes the intragastric intraduodenal pressures were recorded 3 h after ingestion of milk. Bands contractions with same rhythmicity as phase III activity adults frequently recorded. Some them migrated caudally speculated be equivalent interdigestive migrating complex (IMC) However, others did not migrate showed some differences from infants time occurrence,...
We investigated the relationships among gastrointestinal sounds, manometric findings, and small intestinal transit time in healthy fasted humans.Gastrointestinal sounds acquired with two microphones attached to upper lower abdominal walls of subjects were quantified a computer-aided sound analysis program. Antroduodenal contractions recorded by manometry. Small was measured breath hydrogen testing after intraduodenal administration lactulose.The sum amplitudes (sound index) both abdomen...
Intraluminal pressure in the gastric antrum and duodenum was studied 44 children adolescents referred for evaluation because of functional symptoms, including vomiting, abdominal distension, pain. Manometric abnormalities were found 39 patients (89%). Abnormalities during fasting included absence migrating motor complex; retrograde, phase 3-like episodes; increased frequency, decreased duration, amplitude 3 tonic duodenal contractions; nonpropagated bursts consistently low-amplitude or...
Abstract Background Despite the presence of ganglion cells in rectum, some patients have symptoms similar to those Hirschsprung's disease. A consensus has yet be established regarding terminology for these diseases. We defined this group diseases as “allied disorders disease” and compiled guidelines facilitate accurate clinician diagnosis provide appropriate treatment strategies each Methods These were developed using methodologies Medical Information Network Distribution System ( MINDS )....
To obtain precise information on the natural course of gastro-esophageal reflux (GER)-related symptoms in Japanese children, we surveyed prevalence regurgitation or vomiting and other GER-related complications infants visiting for healthy baby check-ups.We interviewed mothers 921 who had visited check-ups at 1, 4, 7 12 months after birth, about number episodes per day, symptoms, milk volume, feeding interval, body position feeding.Of 1-month-old infants, 47.1% one more episode day. This...
It is known that breast milk empties more quickly from the stomach than does infant formula. We studied difference in gastroduodenal motility between neonates fed with human and those Twenty-four five-to 36-day-old were mother's or a cow's milk-based Postprandlial contractions recorded manometrically for three hours. Repetitive, high-amplitude nonmigrating dominant wave form during postprandial period. The number of episodes, duration, amplitude, frequency not different following feedings....
We report the gastrointestinal endoscopic findings in nine patients with Henoch-Schonlein purpura. Eight underwent upper endoscopy, which revealed erosive gastritis one patient, hemorrhagic-erosive duodenitis four, and both one. The rectum sigmoid colon were examined six patients. Aphthoid ulcers noted two. In of these patients, a rectal ulcer was also noted. Severe inflammatory changes angiitis found biopsy specimens obtained from duodenum colon. vascular abnormalities mucosa are similar...
To characterize the histological features of livers patients with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), we studied specimens from 30 diagnosed NICCD genetically analyzing SLC25A13 gene.Liver biopsy were subjected to hematoxylin-eosin, Azan, and Berlin-blue staining.Most showed varying degrees fibrosis. The degree inflammation varied among specimens, half showing moderate or severe inflammatory changes. Fat deposition in hepatocytes was observed almost all...