A5011653532- Diet and metabolism studies
- Polysaccharides and Plant Cell Walls
- Origins and Evolution of Life
- Microbial Metabolites in Food Biotechnology
- Enzyme Production and Characterization
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Biofuel production and bioconversion
- Protein Structure and Dynamics
- Testicular diseases and treatments
- Epilepsy research and treatment
- Dietary Effects on Health
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Molecular spectroscopy and chirality
- Surface Chemistry and Catalysis
- Pharmacological Effects and Toxicity Studies
- Intestinal Malrotation and Obstruction Disorders
- Adrenal Hormones and Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Anesthesia and Pain Management
- Analytical Chemistry and Chromatography
- Enhanced Recovery After Surgery
- Gastrointestinal disorders and treatments
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
University of Tokyo Hospital
2020
Ministry of Health Labour and Welfare
2018
Taisho Pharmaceutical (Japan)
2015-2017
NEC (Japan)
2016
The University of Tokyo
1966-2015
Tokyo University of Science
2009-2015
The Japanese Society of Gastroenterological Surgery
2013
Mie University
2009-2012
Tokyo University of Agriculture and Technology
2011
Kansai Medical University
2009
<italic>P</italic> and <italic>M</italic>-Helical mesoporous silica was found to act as a chiral inorganic trigger for asymmetric autocatalysis afford (<italic>S</italic>) (<italic>R</italic>)-pyrimidyl alkanol with up >99.5% ee, respectively.
In enzymatic saccharification of lignocellulosics, the access enzymes to exposed cellulose surfaces is a key initial step in triggering hydrolysis. However, knowledge structure-hydrolyzability relationship pretreated biomass still limited. Here we used fluorescent-labeled recombinant carbohydrate-binding modules (CBMs) from Clostridium josui as specific markers for crystalline (CjCBM3) and non-crystalline (CjCBM28) analyze complex wood tissues with NaOH, NaOH-Na(2)S (kraft pulping),...
A chiral mineral, cinnabar, served as a source of asymmetric autocatalysis to afford enantioenriched 5-pyrimidyl alkanol. The adsorption structures related compounds were observed with atomic force microscopy. Enantioselective the autocatalyst was found in microcrystal formations at surface cinnabar. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not...
Summary To investigate the regulatory mechanisms of angiogenesis in development myelodysplastic syndromes (MDS) and its progression to overt leukaemia (OL), bone marrow samples from control, paired MDS patients before after transformation OL (MDS → OL) de novo acute myeloid (AML) were analysed. Immunohistochemical staining showed a significant increase microvascular density (MVD) AML compared with controls. Surprisingly, MDS, MVD significantly decreased upon OL, which was also lower than...
Abstract Background Despite the presence of ganglion cells in rectum, some patients have symptoms similar to those Hirschsprung's disease. A consensus has yet be established regarding terminology for these diseases. We defined this group diseases as “allied disorders disease” and compiled guidelines facilitate accurate clinician diagnosis provide appropriate treatment strategies each Methods These were developed using methodologies Medical Information Network Distribution System ( MINDS )....
Chiral isotactic polystyrenes induce the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, affording enantiomerically enriched pyrimidyl alkanol with corresponding absolute configuration that cryptochiral in conjunction asymmetric autocatalysis.
We cloned two glycoside hydrolase family 74 genes, the sav_1856 gene and sav_2574 gene, from Streptomyces avermitilis NBRC14893 characterized resultant recombinant proteins. The product (SaGH74A) consisted of a catalytic domain 2 carbohydrate-binding module at C terminus, while (SaGH74B) only domain. SaGH74A SaGH74B were expressed successfully had molecular masses 92 78 kDa, respectively. Both proteins xyloglucanases. optimal activity 60°C pH 5.5, 55°C 6.0. was stable over broad range (pH...
We previously reported the marked differences in effects of sevoflurane anesthesia and propofol on glucose use fed rats; however, we could not elucidate mechanisms underlying differences.We used fasted rats this study. After surgical preparation under anesthesia, were divided into 3 groups: awake rats, anesthesia. All underwent IV tolerance test (IVGTT); 0.5 g/kg was administered to rats. Just before IVGTT, some pretreated with glibenclamide or diazoxide. measured glucose, insulin, tumor...
The crystal structures of a carbohydrate‐binding module (CBM) family 28 domain endoglucanase Cel5A from Clostridium josui have been determined in ligand‐free and complex forms with cellobiose, cellotetraose, cellopentaose as the first this family. In cleft β‐sandwich fold, ligands are recognized by stacking interactions hydrogen bonds. Conformations bound cellooligosaccharides similar to those crystals solution but clearly different cellulose structure. Interestingly, glucan chain on CBM28...
The effects of anesthesia with sevoflurane and propofol on glucose utilization in rats were investigated. Sevoflurane significantly impairs whereas does not. Both insulin secretion sensitivity affect utilization. Propofol is hydrophobic, this agent always accompanied by an acute lipid load, which can exaggerate resistance. role the load fasted was Rats allocated to groups anesthetized infused physiological saline (group S) or 10% w/v SL), those P). Intravenous tolerance tests then performed...
Endoglucanase Cel5A from Clostridium josui contains a family 17 carbohydrate-binding module (CBM) (CjCBM17) and 28 CBM (CjCBM28) in tandem. These two CBMs bound to non-crystalline cellulose beta-1,3-1,4-glucan. Our results indicate that the recognized different components on cell wall of sweet potato root. The root was cut into longitudinal sections. We used CjCBM17 CjCBM28 fused fluorescent proteins visualize differential recognition plant wall. When they were microscopically observed,...
The endoglucanase Cel5A from an anaerobic celluloltyic bacterium, Clostridium josui, contains family 17 CBM (CjCBM17) and 28 (CjCBM28) in tandem. Individual CjCBM17 CjCBM28 tandem CjCBM17/28 were constructed to determine the binding characteristics of compare affinity three CBMs. bound non-crystalline cellulose, soluble cellulose derivatives, oat-spelt xylan, but not birchwood xylan or starch. thermodynamic parameters for CBMs with cellooligosaccharides determined by isothermal titration...
Pediatric oncology patients who have undergone placement of multiple central venous catheters may thrombosis or stenosis in the upper system. The purpose this study was to identify factors that predict and evaluate role Doppler ultrasonography assessing system pediatric requiring vascular catheters.The medical records eligible were reviewed with regard demographics, primary disease, type catheter, duration previous access, association infection, operative notes, ultrasonographic findings.Our...
Das chirale Mineral Zinnober bewirkt die Bildung von enantiomerenangereichertem 5-Pyrimidylalkanol in einer asymmetrischen Autokatalyse. Die Strukturen dabei auftretender adsorbierter Verbindungen wurden rasterkraftmikroskopisch untersucht. enantioselektive Adsorption des Autokatalysators führte zur Ablagerung Mikrokristallen auf der chiralen Oberfläche Zinnobers.
<i>Introduction:</i> The aim of this study was to assess the efficacies early orchidopexy on later morphological changes in testis using ultrasonography. <i>Materials and Methods:</i> medical records 23 consecutive patients with unilateral undescended operated our institution between 1992 2001 were reviewed historical cohort design. subjects divided into two groups according their age at time surgery: group A included who underwent surgery before 2 (n = 13), B those...