A5066489094- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Genetics and Neurodevelopmental Disorders
- Cardiac Arrhythmias and Treatments
- Infectious Diseases and Tuberculosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Cellular transport and secretion
- Acute Myeloid Leukemia Research
- Pharmacological Effects of Natural Compounds
- Viral Infections and Immunology Research
- Parkinson's Disease Mechanisms and Treatments
- Reproductive tract infections research
- Immune cells in cancer
- Hereditary Neurological Disorders
- Fungal Infections and Studies
- Autoimmune Neurological Disorders and Treatments
- Mitochondrial Function and Pathology
Keio University
2022-2024
Tokyo Medical and Dental University
2007-2022
Tokyo Metropolitan Bokutoh Hospital
2014-2015
Ome Municipal General Hospital
2013
Although the immunological memory produced by BNT162b2 vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well studied and established, further information using different racial cohorts is necessary to understand overall response vaccination. We evaluated B T cell responses spike protein before after third booster a Japanese cohort. Ab titer receptor-binding domain (RBD) decreased significantly 8 mo second vaccination, number of cells continued...
Abstract T cells play important roles in autoimmune diseases, but it remains unclear how to optimally manipulate them. We focused on the cell immunoreceptor with Ig and ITIM domains (TIGIT), a coinhibitory molecule that regulates is expressed cells. In association between TIGIT-expressing pathogenesis function of human-TIGIT (hu-TIGIT) signalling modification have not been fully elucidated. Here we generated anti-hu-TIGIT agonistic monoclonal antibodies (mAbs) hu- TIGIT knock-in mice...
Summary To investigate the regulatory mechanisms of angiogenesis in development myelodysplastic syndromes (MDS) and its progression to overt leukaemia (OL), bone marrow samples from control, paired MDS patients before after transformation OL (MDS → OL) de novo acute myeloid (AML) were analysed. Immunohistochemical staining showed a significant increase microvascular density (MVD) AML compared with controls. Surprisingly, MDS, MVD significantly decreased upon OL, which was also lower than...
COL4A1‐associated disorders encompass a wide range of hereditary vasculopathy, including porencephaly and HANAC (adult‐onset hemorrhagic stroke with cerebral aneurysm retinal arterial tortuosity, renal cysts, thenar muscle cramp). It remains elusive whether or not are molecularly distinctive due to different classes mutations. We report on girl an episode microangiopathic hemolysis in infancy her father HANAC, both whom had heterozygous missense mutation COL4A1 (c.3715G>A, p.G1239R). The...
Abstract Manipulating lymphocyte functions with gene silencing approaches is promising for treating autoimmunity, inflammation, and cancer. Although oligonucleotide therapy has been proven to be successful in several conditions, efficient vivo delivery of populations remains a challenge. Here, we demonstrate that intravenous injection heteroduplex (HDO), comprised an antisense (ASO) its complementary RNA conjugated α-tocopherol, silences endogenous expression higher potency, efficacy, longer...
Regulatory T cells (Tregs) are normally born in the thymus and activated secondary lymphoid tissues to suppress immune responses lymph node at sites of inflammation. Tregs also resident various or accumulate damaged tissues, which now called tissue Tregs, contribute homeostasis repair by interacting with non-immune cells. We have shown that brain during chronic phase a mouse cerebral infarction model, these acquire characteristic properties recovery neurological damage astrocytes. However,...
Microglial activation followed by recruitment of blood-borne macrophages into the central nervous system (CNS) aggravates neuroinflammation. Specifically, in multiple sclerosis (MS) as well experimental autoimmune encephalomyelitis (EAE), a rodent model MS, activated microglia and (Mg/Mφ) promote proinflammatory responses expand demyelination CNS. However, potent therapeutic approach through systemic route for regulating their functions has not yet been developed. Here, we demonstrate that...
Neuropathic pain, a heterogeneous condition, affects 7%-10% of the general population. To date, efficacious and safe therapeutic approaches remain limited. Antisense oligonucleotide (ASO) therapy has opened door to treat spinal muscular atrophy, with many ongoing clinical studies determining its utility. ASO for neuropathic pain peripheral nerve disease requires efficient gene delivery knockdown in both dorsal root ganglion (DRG) sciatic nerve, key tissues signaling. We previously developed...
Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract that frequently accompanied by systemic complications. Neuropathologies have not been well investigated as extraintestinal manifestations CD. We herein report case 36-year-old man with CD who presented progressive weakness and numbness. A neurological examination results nerve conduction study sural biopsy led to diagnosis demyelinating polyradiculoneuropathy (CIDP). Plasma exchanges were initially...
Bilateral internal carotid artery dissection (ICAD) is a rare but important cause of stroke in young adults. Anticoagulant and/or antiplatelet agents are usually recommended for prevention;however, such treatments remain highly controversial, and there inadequate data to compare the efficacy anticoagulation therapy. We herein report case 30-year-old man presenting with progressive bilateral ICAD during treatment. This suggests possibility that intramural hematomas enlarged by anticoagulant...
Spinal epidural abscess (SEA) is a rare infection complicated in patients who have some risk factors such as injection-drug use, diabetes mellitus, and several illnesses. However, no case of SEA associated with abortion has been reported. Here we report 30-year-old woman after dilation curettage for incomplete abortion. The diagnosis was done by MRI pus drained the cervical discectomy. Bacteroides fragilis group cultured from aspirated sample. patient responded to surgical drainage antibiotics.
Objective Cryptococcal meningoencephalitis (CM) causes significant morbidity and mortality in human immunodeficiency virus (HIV)-negative HIV-positive populations. White matter lesions (WMLs) have been reported both populations of CM patients; however, the mechanisms underlying WML formation remain unknown. We herein report relationship between intrathecal immune response development WMLs HIV-negative patients with CM.
OBJECTIVE: To clarify the efficacy of oral rifampicin on multiple system atrophy (MSA).
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Abstract Although BNT162b2 vaccination was shown to prevent infection and reduce COVID-19 severity, the persistence of immunological memory generated by has not been well elucidated. We evaluated B T cell responses SARS-CoV-2 spike protein before after third booster. antibody titer against receptor-binding domain (RBD) decreased significantly 8 months second vaccination, number cells continued increase, while slowly. Memory from unvaccinated infected patients showed similar kinetics. After...