A5013645857- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Congenital Anomalies and Fetal Surgery
- Urological Disorders and Treatments
- Teratomas and Epidermoid Cysts
- Esophageal and GI Pathology
- Neonatal Respiratory Health Research
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Gastrointestinal disorders and treatments
- Tumors and Oncological Cases
- Congenital gastrointestinal and neural anomalies
- Pediatric Urology and Nephrology Studies
- Gallbladder and Bile Duct Disorders
- Vascular Malformations and Hemangiomas
- Immune Response and Inflammation
- Congenital Heart Disease Studies
- Hernia repair and management
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Urologic and reproductive health conditions
- Head and Neck Surgical Oncology
- S100 Proteins and Annexins
- Immune Cell Function and Interaction
- Head and Neck Anomalies
Nihon University
2025
National Center For Child Health and Development
2015-2024
Japan Surgical Society
2020-2024
Japan Pediatric Society
2020
Ministry of Health Labour and Welfare
2018-2019
The University of Tokyo
2003-2016
University of Tokyo Hospital
2004-2014
Keio University
1996-2005
Gifu University
1995-2004
Chiba Cancer Center
2002
We have revealed that about one and a half thousand tiny clusters, filled with closely packed lymphocytes, can be found throughout the murine small large intestinal mucosa. They are located in crypt lamina propria (cryptopatches; CP) first detected at 14-17 d after birth. A fraction of lymphocytes CP expresses c-kit, IL-7R, Thy1 lymphocyte function-associated antigen, LFA-1, whereas most them remain CD3-, TCR alpha beta-, gamma delta-, sIgM-, B220-. The population size IL-2R alpha+, HSA+...
Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs small intestine that were c-kit positive (c-kit + ) but lineage markers negative (Lin − gave rise to T cell receptor (TCR) αβ and TCR γδ intraepithelial cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, Peyer's patches mesenteric lymph nodes, which belong same compartment lack Lin cells, failed do so. These findings results electron...
Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis treatment, it was considered necessary to formulate evidence-based clinical practice guidelines reflecting the most progress, guide of neonatologists, pediatric endocrinologists, general pediatricians, surgeons. These cover range aspects, including features congenital hyperinsulinism, diagnostic criteria tools for diagnosis, first- second-line medical details surgical future perspectives. were...
We aimed to investigate the nationwide incidence, treatment details and outcomes of patients with endogenous hyperinsulinemic hypoglycemia (EHH), including those transient/persistent congenital hyperinsulinism (CHI), insulinoma, non-insulinoma pancreatogenous syndrome insulin autoimmune (Hirata's disease) in Japan.
Abstract Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, transcriptome analyses, of 59 samples. Based on methylation patterns, was classified into three clusters exhibiting remarkable correlation with clinical, histological, features. Cluster F largely composed cases fetal histology good outcomes, whereas E1 E2...
Abstract Lympho-hemopoietic progenitors residing in murine gut cryptopatches (CP) have been shown to generate intestinal intraepithelial T cells (IEL). To investigate the role of CP progenitor maturation, we analyzed IEL male mice with a truncated mutation common cytokine receptor γ-chain (CRγ−/Y) which were undetectable. IEL-expressing TCR-γδ (γδ-IEL) absent, and drastically reduced number Thy-1highCD4+ Thy-1highCD8αβ+ αβ-IEL present CRγ−/Y mice, whereas these disappeared from athymic...
Abstract Background Despite the presence of ganglion cells in rectum, some patients have symptoms similar to those Hirschsprung's disease. A consensus has yet be established regarding terminology for these diseases. We defined this group diseases as “allied disorders disease” and compiled guidelines facilitate accurate clinician diagnosis provide appropriate treatment strategies each Methods These were developed using methodologies Medical Information Network Distribution System ( MINDS )....
Abstract Background Multicenter study was undertaken to analyze the results of laparoscopic and open Kasai portoenterostomy. Methods Subjects were infants with type III biliary atresia who underwent operation ( n = 106) or 21) between January 2012 December 2015. Clinical data compared operations (2016‐0534). Propensity score matching performed reduce effect treatment selection bias. Multivariate analyses used estimate surgical approach on jaundice clearance rate native liver survival rate....
Abstract Background Biliary atresia (BA) is an intractable disease of unknown cause that develops in the neonatal period. It causes jaundice and liver damage due to destruction extrahepatic biliary tracts,. We have found heterozygous knockout mice SRY related HMG-box 17 (Sox17) gene, a master regulator stem/progenitor cells gallbladder wall, exhibit condition like BA. However, precise contribution hypoplastic wall pathogenesis hepatobiliary Sox17 embryos human BA remains unclear. Methods...