A5068118056- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Tumors and Oncological Cases
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Tuberous Sclerosis Complex Research
- Vascular Tumors and Angiosarcomas
- Histiocytic Disorders and Treatments
- Oral and Maxillofacial Pathology
- Gastrointestinal disorders and treatments
- Teratomas and Epidermoid Cysts
- RNA regulation and disease
- Neuroendocrine Tumor Research Advances
- Protein Degradation and Inhibitors
- Vascular anomalies and interventions
- Genetic and Kidney Cyst Diseases
- Hepatitis C virus research
- Tracheal and airway disorders
Kanagawa Children's Medical Center
2015-2024
Institute of Parasitology
2024
Niigata University
2019-2022
Adult Congenital Heart Association
2020
Kanazawa Medical University
2020
Shimane University
2020
Hiroshima University
2011-2019
Universidade de São Paulo
2013
SUNY Upstate Medical University
2013
University of California, San Francisco
2013
This study concerns the significance of nuclear/cytoplasmic expression beta-catenin and mutation gene in craniopharyngiomas. Fourteen adamantinomatous type one squamous papillary craniopharyngiomas were studied. Histologically, 13 14 showed typical features, ie mixtures 'palisading cells', 'stellate 'ghost cells'. In addition, 'whorl-like arrays' epithelial cells frequently observed areas stellate cells. On immunohistochemistry, all predominantly cohesive within whorl-like arrays...
We report a case of perivascular epithelioid cell tumor (PEComa) with an SFPQ/PSF-TFE3 gene fusion in 14-year-old girl treated for adrenal neuroblastoma 4 years. Imaging studies revealed the wall sigmoid colon, which was radiologically different from neuroblastoma, together several inguinal and cervical lymph node metastases neuroblastoma. Microscopically, colon showed sheet-like growth cells abundant clear cytoplasm round nuclei, were separated by thin fibrovascular septa. These...
Aim: In this study, we evaluated the clinical characteristics of hepatocellular carcinoma (HCC) because etiology HCC has been changing recently. Methods: Consecutive 1374 patients at our institution from 1995 to 2009 were enrolled and investigated. Results: Seventeen percent 67% related hepatitis B virus (HBV‐HCC) C (HCV‐HCC), respectively. Fifteen that was negative for surface antigen (HBsAg) antibody (HCVAb) (NBNC‐HCC). HCV‐HCC tended decrease NBNC‐HCC increase in recent years. Patients...
To compare the assessment of response and prognosis patients to sorafenib treatment by Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), α-fetoprotein (AFP) des-γ-carboxy prothrombin (DCP).Sixty-six with advanced hepatocellular carcinoma (HCC) treated were enrolled this retrospective study. The was evaluated RECIST, mRECIST changes AFP DCP.The median survival time all 8.6 months. radiological progression 3.3 rates [complete (CR) + partial (PR)] 3.0 9.0%,...
In this study, we report 2 pediatric cases of nuclear protein the testis (NUT) midline carcinoma (NMC) suggestive pulmonary origin: case 1 was a 14-year-old Japanese boy and 7-year-old girl. Initial symptoms both were prolonged cough chest pain, patient also complained lumbago lumbar mass due to bone metastases. Imaging studies revealed that tumors from patients located at hilar region lower lobe. Biopsies showed undifferentiated in combined squamous cell 2. Despite intensive treatment with...
Abstract Although hepatoblastoma is the most common pediatric liver cancer, its genetic heterogeneity and therapeutic targets are not well elucidated. Therefore, we conducted a multiomics analysis, including mutatome, DNA methylome, transcriptome analyses, of 59 samples. Based on methylation patterns, was classified into three clusters exhibiting remarkable correlation with clinical, histological, features. Cluster F largely composed cases fetal histology good outcomes, whereas E1 E2...
We compared the treatment response, survival, and safety to hepatic arterial infusion chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC) according Child-Pugh (CP) score.The study subjects were 249 HCC CP class A B who had been treated HAIC. Patients grouped score (5/6, 7 8/9) their tumor tolerance, survival assessed.The median time (MST) was 8.2, 9.7, 6.3, 3.9 months for whole group, 5/6, 8/9, respectively (P < 0.0001). Complete response (CR) partial (PR) seen 11 57...
The antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2) is localized in the cytosol and mitochondria, while evolutionarily-related rhodanese (thiosulfate sulfurtransferase, TST, 2.8.1.1) mitochondria. Recently, both enzymes have been shown to produce hydrogen sulfide polysulfide. Subcellular fractionation of liver mitochondria revealed that TST activity ratio MST-knockout (KO)/wild-type mice was approximately 2.5; MST detected only wild-type mice, as expected. mRNA...
In the present study significance of nuclear/cytoplasmic expression beta-catenin (CTNNB1) and mutation CTNNB1 gene in odontogenic tumors was examined. Six ameloblastomas (five follicular one plexiform ameloblastoma) three malignant (one metastasizing ameloblastoma, ameloblastic carcinoma, primary intraosseous carcinoma) were investigated for mutation. Immunohistochemically, all carcinoma exhibited focal moderate CTNNB1, whereas ameloblastoma remaining two had entirely membranous expression....
We present a case of scurvy in 6-year-old boy with autism and an unbalanced diet. The patient was admitted difficulties walking. Magnetic resonance imaging findings the thigh showed diffuse signal abnormality bone marrow, periosteum, femoral muscle. A biopsy specimen femur hematoma, proliferative fibroblasts, few collagen fibers, which suggested deficiency vitamin C. Although recurrent periosteal hematoma may be suggestive scurvy, this finding subtle current case. It is important to aware...
Spinal atypical teratoid/rhabdoid tumor (AT/RT) is a rare, aggressive malignant neoplasm of the central nervous system usually seen in young children and infants. We present diffusion-weighted imaging (DWI) findings for an intradural extramedullary AT/RT cervical spine 6-year-old boy. High signal on DWI low apparent diffusion coefficients may represent high cellularity tumor. These indicated highly
Abstract Background A nationwide mass screening for neuroblastoma (NBL) in 6‐month‐old infants (MS6M) was performed Japan from 1985 to 2003. Favorable biological features were identified most of the detected tumors; consequently, we began an observation program selected screened patients 1993. Here, report clinicopathological findings and present status enrolled our program, with goal evaluating its usefulness. Procedure Between 1993 2003, 53 101 NBL by MS6M enrolled. The divided into four...
Abstract Background The prognosis of metastatic hepatoblastoma remains poor; to improve it, pulmonary metastasis must be controlled. Indocyanine green (ICG) fluorescent imaging has been used recently for lung metastasectomy. objective our study was clarify the usefulness ICG metastasectomy using detailed clinicopathological analysis. Procedure Patients with who underwent resection metastases were studied a retrospective analysis clinical information, review their surgical records, and...
We herein report a case of hepatitis-associated aplastic anemia (HAAA) that occurred after severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) vaccination. In this patient, progressive pancytopenia observed two months hepatitis following the second dose SARS-Cov-2 vaccine indicated development HAAA. Although some reports have suggested vaccination may be involved in autoimmune diseases, no cases HAAA developing been reported. children has only started relatively recently, so range...
Clear cell sarcoma of the kidney (CCSK) although uncommon, is second most frequent renal malignancy childhood. Until now, sole recurrent genetic aberration identified in CCSKs t(10;17)(q22;p13), which gives rise to a fusion transcript YWHAE and NUTM2B/E . So far, clinical relevance this unknown. The aim descriptive study was determine phenotype t(10;17)(q22;p13) positive CCSKs. Snap‐frozen tissues, formalin‐fixed paraffin‐embedded tissues or RNA previously extracted from CCSK samples...
Hepatoblastoma (HB) is the most common malignant liver neoplasm in children. Despite progress HB therapy, outcomes for patients with metastatic disease remain poor. Dysregulation of miRNA expression one potential epigenetic mechanisms associated pathogenesis HB. However, profiles related to different stages tissues and cells, particular lung tumor are unknown. In present study, using array-based DNA methylation analysis on formalin-fixed paraffin-embedded tissues, we aimed identify changes...